Search Results - yanyun+liu

20 Results

Sort By:

In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Published: 6/5/2024 | Inventor(s): Li Liu, Jingmin Shu

Keywords(s):

Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices

An OCT method to improve scleral lens fitting

Summary The current technology allows for accurate and objective 3-dimensional (3D) mapping of the external limbus, which could ultimately improve the process of scleral lens fitting. Technology Overview Rigid scleral lenses are difficult to fit to patients because they must rest on the eye but vault over the cornea and the limbus, which is the transition...

Published: 1/5/2024 | Inventor(s): David Huang, Yan Li, Clara Llorens Quintana

Keywords(s): Imaging, Imaging - Other, Software, Software - Diagnostic/Detection

Category(s): Imaging, Software

Novel Anti-HIV Compounds Using Peptides or Peptide Mimetics

Abstract: The subject invention describes a new class of compounds (such as peptides or mimetics) that target viral RNAs and inhibit the viral life cycle by blocking the viral recognition process. More specifically, these compounds are the first against an RNA Target - currently there are no clinical drugs against RNA targets in the treatment of any...

Published: 4/8/2024 | Inventor(s): Yun-Xing Wang, Liu Yu, Ping Yu, Ina O'Carroll

Keywords(s): Anti-Viral, HIV

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease

Method and Device for Selectively Labeling RNA

Abstract: Current methods of labeling and synthesizing RNA do not allow for multiple labels or long RNA segments to be synthesized for large RNA on a milligram scale. Investigators at the NCI Structure Biophysics Lab and UT Health Science Center have developed a method to selectively label RNA at specific residues and/or segments using a hybrid solid-liquid...

Published: 12/10/2024 | Inventor(s): Yun-Xing Wang, Liu Yu, Rui Sousa

Keywords(s): crystallography, Fluorophore labeling, FRET, Isotope labeling, Labeling sensor, NMR Spectroscopy

Category(s): Application > Diagnostics, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Real-Time RT-PCR Assay for the Rapid Detection of Rabies and Other Lyssaviruses

Rabies occurs in more than 150 countries and territories, resulting in at least 55,000 human deaths per year worldwide according to World Health Organization estimates. Rabies is a vaccine-preventable viral disease caused by numerous lyssaviruses that are found in a variety of animal species throughout the world. Rabies virus infects the central nervous...

Published: 10/28/2024 | Inventor(s): Yu Li

Keywords(s): assay, DA4XXX, DDXXXX, Diagnostics, LYSSAVIRUSES, Modified, NCEZID, NCEZID-DHCPP, Non-rabies, Probe, rabies, REAL-TIME, RT-PCR, VLXXXX, VOXXXX, WBXXXX, WGXXXX, WHXXXX, WIXXXX, XEXXXX, YBXXXX, YGXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

Universal Diagnostic Assay for Detection and Identification of Poxviruses in Clinical Samples

CDC researchers have developed an assay for detection and diagnosis of poxviruses within clinical samples or from lab culture-systems. The assay specifically targets chordopoxviruses (except avipoxviruses) for PCR-based identification; an improvement upon the current standard of cell culturing methodologies. Individual chordopoxvirus species can cause...

Published: 10/28/2024 | Inventor(s): Inger Damon, Hui Zhao, Yu Li

Keywords(s): ASSAYS, CDC Docket Import, CDC Docket Import CDC Prosecuting, CHORDOPOXVIRUSES, DA4BXX, DA4XXX, DAXXXX, diagnostic, DXXXXX, OID-NCEZID-DHCPP, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Diagnostics, Application > Research Materials

Method for 3D Nonlinear Structured Illumination Super-resolution Imaging

Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...

Published: 4/3/2023 | Inventor(s): Leilei Peng, Yu Li, Han Zhang

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 7/30/2024 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

Novel Compounds Inhibiting COVID-19 Replication

This technology is three potential pharmacological treatment options for COVID-19. The inventors identified three compounds, two naturally occurring and one small-molecule. These compounds target and inhibit the main 3CL protease that is essential to the replication of SARS-CoV-2 and have been shown to be effective against the virus in vitro. Background: In...

Published: 4/3/2023 | Inventor(s): Rui Chang, Dominik Schenten, Patrick Ronaldson, Yanyun Liu, Vijayan Ramachandran

Keywords(s):

Category(s): Technology Classifications > Life Sciences

Combinations for the Treatment of Neurodegeneration

Researchers at the University of Arizona have researched new formulations and combinations of compounds for the treatment of Alzheimer’s disease. Developing a novel computational system allowed the inventors to identify several therapeutic targets of single cell type and whole bulk tissue that contribute to Alzheimer's disease. These therapeutic...

Published: 4/3/2023 | Inventor(s): Rui Chang, Patrick Ronaldson, Wei Wang, Vijayan Ramachandran, Yanyun Liu, Qianying He

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Life Sciences

1 2