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Search Results - rui+sousa
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Method and Device for Selectively Labeling RNA
Abstract: Current methods of labeling and synthesizing RNA do not allow for multiple labels or long RNA segments to be synthesized for large RNA on a milligram scale. Investigators at the NCI Structure Biophysics Lab and UT Health Science Center have developed a method to selectively label RNA at specific residues and/or segments using a hybrid solid-liquid...
Published: 12/10/2024
|
Inventor(s):
Yun-Xing Wang
,
Liu Yu
,
Rui Sousa
Keywords(s):
crystallography
,
Fluorophore labeling
,
FRET
,
Isotope labeling
,
Labeling sensor
,
NMR Spectroscopy
Category(s):
Application > Diagnostics
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
System for Selectively Labeling RNA
The invention pertains to a three step initiation, elongation and termination method and platform for synthesizing selectively labeled RNA molecules by first polymerizing a first liquid phase RNA molecule from a solid phased DNA template fixed onto a solid phase. Background:The method includes the steps of incubating the solid and liquid phases at appropriate...
Published: 5/22/2024
|
Inventor(s):
Rui Sousa
,
Yun-Xing Wang
,
Liu Yu
,
Ping Yu
Keywords(s):
Category(s):
Life Sciences Research Tools > Genomics
A High-Efficiency System for in vitro and in vivo Biotinylation
A novel system with an improved efficiency for in vitro, as well as in vivo, biotinylation of a large amount of Avi-tagged target proteins. This system is an improvement over the only pre-existing commercial systems available for in vivo biotinylation because it greatly improves biotinylation efficiency and enables the complete labeling of target proteins....
Published: 9/12/2018
|
Inventor(s):
Yifeng Li
,
Rui Sousa
Keywords(s):
Category(s):
Life Sciences Research Tools > Enzymes