Search Results - xingchen+liu

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CBLs as a biomarker of and target to treat systemic lupus erythematosus (SLE)
SLE DIAGNOSTIC TOOL CBL protein levels used as a molecular diagnostic marker to diagnose and assess severity of Systemic Lupus Erythematosus (SLE) Systemic Lupus Erythematosus patient (photo: NCRD) UNMET NEED Systemic Lupus Erythematosus (SLE) is an autoimmune disease, especially prevalent in women, and without curative treatment. In addition,...
Published: 7/7/2025   |   Inventor(s): Xin Li, Zhe-Xiong Lian, Hua Gu
Keywords(s): Innovation
Category(s): Applications > Soins et santé > Diagnostic, English Applications > Health and care > Diagnostic-ENG, Secteurs > Sciences de la vie, Sectors > Life sciences, Objectifs de Développement Durable > ODD 03 : Bonne santé et bien-être, Sustainable Development Goals > Goal 03: Good Health and Well-Being
CNN Architecture for Disease Identification from Retinal Images
The rise of artificial intelligence is changing the shape of many different fields, and ophthalmic medicine is no exception. Convolutional neural networks (CNNs) have achieved remarkable results in the assisted diagnosis of ophthalmic diseases. However, they face challenges such as limited labeling and small dataset sizes. In recent years, self-supervised...
Published: 3/19/2025   |   Inventor(s): Yalin Wang, Xin Li, Wenhui Zhu, Oana Dumitrascu
Keywords(s): Medical Devices and Imaging, Medical Software
Category(s): Artificial Intelligence/Machine Learning, Computing & Information Technology, Imaging, Life Science (All LS Techs), Medical Imaging
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 2/13/2025   |   Inventor(s): Li Liu, Jingmin Shu
Keywords(s):  
Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices
Fully Human Antibody Targeting Tumor Necrosis Factor Receptor Type 2 (TNFR2) for Cancer Immunotherapy
Abstract: Tumor necrosis factor receptor type 2 (TNFR2)-expressing regulatory T cells (Tregs), present in the tumor microenvironment, play an important role in tumor immune evasion. TNFR2 plays a crucial role in stimulating the activation and proliferation of Tregs, a major checkpoint of antitumor immune responses. In addition to its expression on Tregs,...
Published: 4/22/2025   |   Inventor(s): Joost Oppenheim, Dimiter Dimitrov, De Yang, Xin Chen, Zhongyu Zhu
Keywords(s): ADCC, ANTIBODY, Antibody-dependent Cellular Cytotoxicity, CANCER, Immunotherapy, Oppenheim, TNFR2, Tregs, Tumor Necrosis Factor Receptor Type 2
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Method for Producing Amphiphilic and Amphoteric Soy Protein Colloids, Sub-Micron Fibers, and Microfibrils
SUMMARYResearchers at the University of California, Davis have developed a method for converting high molecular weight and complex globular proteins such as soy and pea into amphiphilic and amphoteric colloids, sub-microns fibers, and microfibrils important to multiple consumer and industrial applications.BACKGROUNDSoy proteins, a major (4 times in...
Published: 3/13/2023   |   Inventor(s): You-Lo Hsieh, Xingchen Liu
Keywords(s):  
Category(s): Technology Classifications > Materials & Chemicals > Chemicals (M&C), Technology Classifications > Materials & Chemicals > Textiles, Technology Classifications > Materials & Chemicals > Thin Films, Technology Classifications > Other > Other: Engineering
Metabolic activity diffusion imaging (MADI): dye-free, high-resolution MRI metabolic imaging
Summary The current technology is a contrast agent-free method of metabolic imaging based on detection of Na/K ATPase activity with MRI, that provides significantly higher resolution than current approaches such as PET. Technology Overview Measuring metabolic activity in vivo can facilitate diagnoses of disease states and therapeutic responses....
Published: 1/15/2024   |   Inventor(s): Gregory Wilson, Jeffrey Maki, Charles Springer, Jr., Xin Li, William (Bill) Rooney, Brendan Moloney, Wei Huang, Tom Barbara, Eric Baker
Keywords(s): Diagnostics, Imaging, Imaging - MRI, Software, Software - Other
Category(s): Imaging, Software
A Gamma-ray Photon Counting Detector Based on Side-readout of Monolithic Scintillator Layers
Researchers at the University of Arizona have developed a gamma-ray photon counting device that works similarly to PET, but with a novel architecture that improves the accuracy and speed in determining the location of the biological targets, and is less costly to manufacture. Background: Positron Emission Tomography (PET) is a common and reliable...
Published: 11/22/2023   |   Inventor(s): Lars Furenlid, Xin Li
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Sensors and Detection
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/28/2025   |   Inventor(s): Yu Qian, Yi Wang, Chen Chen
Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation
Category(s): Engineering and Physical Sciences
Intelligent Multi-Beam Medium Access Control in Ku-Band for Mission-Oriented Mobile Mesh Networks
­ The Problem: There are existing similar technologies, but these technologies are not designed for mobile mission-oriented applications. The use of Ku-band frequency on two separate information transmission levels reduces interference common with current multi-beam antennas. Also, the Ku-band frequency is not the currently used frequency range...
Published: 2/27/2023   |   Inventor(s): Fei Hu, xI Li, Sunil Kumar
Keywords(s):  
Category(s): Technology Classifications > Communication
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