Search Results - xingchen+liu

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In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Published: 6/5/2024 | Inventor(s): Li Liu, Jingmin Shu

Keywords(s):

Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices

Fully Human Antibody Targeting Tumor Necrosis Factor Receptor Type 2 (TNFR2) for Cancer Immunotherapy

Abstract: Tumor necrosis factor receptor type 2 (TNFR2)-expressing regulatory T cells (Tregs), present in the tumor microenvironment, play an important role in tumor immune evasion. TNFR2 plays a crucial role in stimulating the activation and proliferation of Tregs, a major checkpoint of antitumor immune responses. In addition to its expression on Tregs,...

Published: 5/22/2024 | Inventor(s): Joost Oppenheim, Dimiter Dimitrov, De Yang, Xin Chen, Zhongyu Zhu

Keywords(s): ADCC, ANTIBODY, Antibody-dependent Cellular Cytotoxicity, CANCER, Immunotherapy, Oppenheim, TNFR2, Tregs, Tumor Necrosis Factor Receptor Type 2

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Method for Producing Amphiphilic and Amphoteric Soy Protein Colloids, Sub-Micron Fibers, and Microfibrils

SUMMARYResearchers at the University of California, Davis have developed a method for converting high molecular weight and complex globular proteins such as soy and pea into amphiphilic and amphoteric colloids, sub-microns fibers, and microfibrils important to multiple consumer and industrial applications.BACKGROUNDSoy proteins, a major (4 times in...

Published: 3/13/2023 | Inventor(s): You-Lo Hsieh, Xingchen Liu

Keywords(s):

Category(s): Technology Classifications > Materials & Chemicals > Chemicals (M&C), Technology Classifications > Materials & Chemicals > Textiles, Technology Classifications > Materials & Chemicals > Thin Films, Technology Classifications > Other > Other: Engineering

Metabolic activity diffusion imaging (MADI): dye-free, high-resolution MRI metabolic imaging

Summary The current technology is a contrast agent-free method of metabolic imaging based on detection of Na/K ATPase activity with MRI, that provides significantly higher resolution than current approaches such as PET. Technology Overview Measuring metabolic activity in vivo can facilitate diagnoses of disease states and therapeutic responses....

Published: 1/15/2024 | Inventor(s): Gregory Wilson, Jeffrey Maki, Charles Springer, Jr., Xin Li, William (Bill) Rooney, Brendan Moloney, Wei Huang, Tom Barbara, Eric Baker

Keywords(s): Diagnostics, Imaging, Imaging - MRI, Software, Software - Other

Category(s): Imaging, Software

A Gamma-ray Photon Counting Detector Based on Side-readout of Monolithic Scintillator Layers

Researchers at the University of Arizona have developed a gamma-ray photon counting device that works similarly to PET, but with a novel architecture that improves the accuracy and speed in determining the location of the biological targets, and is less costly to manufacture. Background: Positron Emission Tomography (PET) is a common and reliable...

Published: 11/22/2023 | Inventor(s): Lars Furenlid, Xin Li

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Sensors and Detection

Novel Multi-Omics Aging Clock

A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...

Published: 3/12/2024 | Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools

Autonomous Drone for railroad track inspection

Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...

Published: 3/15/2023 | Inventor(s): Yu Qian, Yi Wang, Chen Chen

Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation

Category(s): Engineering and Physical Sciences

Intelligent Multi-Beam Medium Access Control in Ku-Band for Mission-Oriented Mobile Mesh Networks

The Problem: There are existing similar technologies, but these technologies are not designed for mobile mission-oriented applications. The use of Ku-band frequency on two separate information transmission levels reduces interference common with current multi-beam antennas. Also, the Ku-band frequency is not the currently used frequency range...

Published: 2/27/2023 | Inventor(s): Fei Hu, xI Li, Sunil Kumar

Keywords(s):

Category(s): Technology Classifications > Communication

Scalable two-phase cooling plates

Reference #: 01575 The University of South Carolina is offering licensing opportunities for Scalable two-phase cooling plates Background: Two-phase cooling usually fails at relatively low heat loads due to the loss of liquid supply. For real applications, two-phase cooling technologies need to match the size of electronic components. However, the...

Published: 11/7/2022 | Inventor(s): Chen Li, Wei Chang, Enrico Santi, Bo Tian

Keywords(s): cold plate, high power device, Thermal management, Two-phase cooling

Category(s): Engineering and Physical Sciences, Software and Computing

A Mechanism and Method for Synthesis of a 2-D Gamma-ray Pinhole Projection Image from a Plurality of Slit Projection Images

This invention is a 3D medical imaging technique that incorporates single photon emission computed tomography (SPECT) to image radioisotope distributions, which are generally used to detect/monitor cancer, drug delivery, etc. This imaging technique uses SPECT to take 2D and 3D tomographic images of radioisotope distributions, both of which can be analyzed...

Published: 4/3/2023 | Inventor(s): Lars Furenlid, Xin Li

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics > Medical Imaging

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