Search Results - xiaoming+zhu

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Telomere assay for the detection of alternative lengthening of telomere (ALT) activity in cells
PAGE TITLE Overview PAGE SUMMARY Executive Statement: A unique tool for distinguishing cancer cells based on telomere maintenance mechanisms, providing potential biomarkers for cancer subtypes and therapeutic responses. Description: This technology provides detailed telomere profiling from individual chromosomes, capable of differentiating...
Published: 6/28/2024   |   Inventor(s): Ming Xiao
Keywords(s):  
Category(s): Life Sciences, Medical Devices & Diagnostics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Research Tools & Materials
Quantification of On-off target gene editing by optical mapping
PAGE TITLE Overview PAGE SUMMARY Executive Statement: A revolutionary methodology for quantifying on-target and off-target gene editing activity using CRISPR-Cas9 and optical mapping. Description: This technology comprises a single-molecule optical mapping strategy using CRISPR-Cas9 to fluorescently label the modified genes. The method involves...
Published: 6/28/2024   |   Inventor(s): Ming Xiao, Yilin Wang, Lahari Uppuluri
Keywords(s):  
Category(s): Life Sciences, Medical Devices & Diagnostics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Research Tools & Materials, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering
Multicolor whole-genome mapping for genetic analysis
PAGE TITLE Overview PAGE SUMMARY Executive Statement: A novel method for precise genome mapping and sequencing using Cas9-mediated labeling within nanochannels. Description: This technology is a method for mapping a whole genome using a universal multi-color mapping strategy in nanochannels that combines a conventional sequence-motif labeling...
Published: 6/20/2024   |   Inventor(s): Ming Xiao, Lahari Uppuluri
Keywords(s):  
Category(s): Life Sciences, Medical Devices & Diagnostics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Research Tools & Materials
Linked-read sequencing library preparation
PAGE TITLE Overview PAGE SUMMARY Executive Statement: Innovative methods for generating sequence-linked DNA fragments for high-quality, low-cost genome sequencing. Description: This technology describes a novel strategy to construct a long-read sequencing library such that adjacent fragments are linked with end-terminal duplications. The...
Published: 6/28/2024   |   Inventor(s): Ming Xiao, Lahari Uppuluri
Keywords(s):  
Category(s): Life Sciences, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Research Tools & Materials
Single molecule real-time long DNA mapping and sequencing
PAGE TITLE Overview PAGE SUMMARY Executive Statement: The invention offers an innovative way to immobilize and optically map/sequence oligonucleotides on a micropatterned substrate for efficient large-scale genomic assembly. Description: This technology presents a method for immobilizing and linearizing oligonucleotides on a micropatterned...
Published: 6/20/2024   |   Inventor(s): Ming Xiao, Dharma Varapula, Eric LaBouff, Moses (hongseok) Noh
Keywords(s):  
Category(s): Medical Devices & Diagnostics, Computing, Software, Analytics & Information Technology > Computing: Bioinformatics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Life Sciences, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Research Tools & Materials
CRISPR-Cas9 Labeling of Human Genomic DNA for Telomere Length Measurement
PAGE TITLE Overview PAGE SUMMARY Executive Statement: An innovative method for the precise detection and measurement of individual telomere lengths that can be correlated to specific chromosomes. Description: This technology provides a method for detecting the length of individual telomeres in genomic DNA using a unique combination of guide...
Published: 4/6/2024   |   Inventor(s): Ming Xiao, Jennifer McCaffrey
Keywords(s):  
Category(s): Medical Devices & Diagnostics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Life Sciences, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Pharmaceuticals & Therapeutics > Pharma: Oncology
Novel Human Insulin Cα-Peptide as an Antagonist for Islet and Brain Amyloidosis
Abstract: Over 32 million Americans are living with Diabetes and newly diagnosed cases of type 1 and type 2 diabetes is increasing. A defining feature of type 2 diabetes mellitus (T2DM) is the accumulation of islet amyloid polypeptide (IAPP) fibrils in pancreatic islets. Such accumulations form amyloid plaques, referred to as islet amyloidosis. Mounting...
Published: 4/8/2024   |   Inventor(s): Qing Rong Liu, Min Zhu, Pingbo Zhang, Josephine Egan, Luigi Ferrucci
Keywords(s): Alzheimer’s Disease, Amyloidosis, C-peptide, DIABETES, Egan, insulin, Islet Amyloid Polypeptide, Liu, National Institute on Aging, NIA
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Endocrinology
Novel Human Islet Amyloid Polypeptides as Alzheimer’s Disease Biomarkers and Inhibitors of Amyloid Formation
Abstract: Over 34 million Americans are living with diabetes. An estimated 6.5 million Americans are living with Alzheimer’s disease (AD) and type 2 diabetes mellites (T2DM). Amyloidosis due to aggregation of amyloid-β is key pathogenic event in AD, whereas aggregation of mature islet amyloid polypeptide (IAPP37) in human islet leads to β-cell dysfunction....
Published: 5/23/2024   |   Inventor(s): Qing Rong Liu, Min Zhu, Josephine Egan
Keywords(s): Ad, Age-Associated Disease, Alzheimer’s Disease, Amyloidosis, Amyloids, Biomarkers, DIABETES, IAPP, Islet Amyloid Polypeptide Isoforms, Liu, National Institute on Aging, NIA, PEPTIDYL
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
Methods of specifically labeling nucleic acids using CRISPR/Cas9
se; } PAGE TITLE Overview PAGE SUMMARY Executive Statement: A new genome analysis technique that uses guide RNA and Cas9 nickase to detect target nucleic acid sequences using fluorescent labeling. Description: The technology involves a method for sequence-specific labeling that can target repetitive regions in the genome. This method contacts...
Published: 4/6/2024   |   Inventor(s): Ming Xiao, Jennifer McCaffrey, Harold Riethman, Wenhui Hu
Keywords(s):  
Category(s): Medical Devices & Diagnostics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Medical Devices & Diagnostics > MDD: Point of Care Diagnostics
Whole genome mapping by DNA sequencing with linked paired-end library
se; } PAGE TITLE Overview PAGE SUMMARY Executive Statement: A novel and highly efficient method of sequencing and mapping the whole genome, promising increased accuracy and lower costs. Description: This technology addresses challenges in genomics like accurate de novo genome assembly and structural variant analysis. It proposes a more efficient...
Published: 6/28/2024   |   Inventor(s): Ming Xiao, Justin Sibert
Keywords(s):  
Category(s): Medical Devices & Diagnostics, Computing, Software, Analytics & Information Technology, Computing, Software, Analytics & Information Technology > Computing: Bioinformatics, Medical Devices & Diagnostics > MDD: Diagnostic Tests
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