PAGE TITLE
Overview
PAGE SUMMARY
A novel and highly efficient method of sequencing and mapping the whole genome, promising increased accuracy and lower costs.
This technology addresses challenges in genomics like accurate de novo genome assembly and structural variant analysis. It proposes a more efficient approach to sequencing and genome mapping using a method of generating linked-paired-end nucleic acid fragments from a DNA sample. The method promises to offer a better resolution of haplotypes, reduce the complexity, time, and cost of sequencing projects, and enhance the detection and analysis of structural variations in the genome.
ADVANTAGES
TITLE:Key Advantages
Greater accuracy in genome assembly and structural variant analysis
Improved efficiency and reduced complexity of the sequencing project
Reduced time and cost
Enhanced detection of structural variations
Problem Solved
TITLE:Problems Solved
Challenges in cloning large DNA fragments
Difficulty in sequencing highly repetitive sequences
Issues with positional information regarding the locations of copy number variant
APPLICATIONS
TITLE: Market Applications
Whole genome sequencing for research, clinical, and medical applications
Genetic testing and personalized medicine
Research in infectious and autoimmune diseases
Biotechnological applications in agriculture, animal breeding, etc.
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IP STATUS
Intellectual Property and Development Status
US Patent Issued #US9758780B2 - Whole genome mapping by DNA sequencing with linked-paired-end library
PUBLICATIONS
References
Pubinfo should be the citation for your publication. Publink is the full url linking to the publication online or a pdf.
Nature Scientific Reports 2024: A long-read sequencing strategy with overlapping linkers on adjacent fragments (OLAF-Seq) for targeted resequencing and enrichment.
Commercialization Opportunities
This invention is part of a larger portfolio of technologies available for licensing and commercialization around TOOLS FOR GENOMIC APPLICATIONS POWERED BY CRISPR/CAS9 BASED DNA LABELING
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Contact Information
For Intellectual Property and Licensing inquiries
Tanvi Muni, PhD
Licensing Manager,
Drexel Applied Innovation
Office of Research and Innovation
3250 Chestnut Street, Ste. 3010 Philadelphia, PA 19104
Phone:267-359-5640
Email:tanvi.muni@drexel.edu
Inventor information
Ming Xiao, PhD
Professor School of Biomedical Engineering, Science and Health Systems
Phone:215-895-2690
Email:mx44@drexel.edu
Inventor Webpage