Search Results - vectors%2fconstructs%2fplasmids

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Increasing the Antigenic Insertion Sites on the Recombinant Immune Complex Platform
Recombinant protein subunit vaccines offer an improved safety profile compared to live attenuated or inactivated vaccines, making them a promising vaccine strategy. These vaccines can further enhance immunogenicity through fusion with IgG-based protein scaffolds, such as immune complex (RIC) platforms. RIC consists of an antibody and antigen complex...
Published: 9/18/2023   |   Inventor(s): Hugh Mason, Mary Pardhe, Andrew Diamos
Keywords(s):  
Category(s): Vectors/Constructs/Plasmids, Vaccines/Antimicrobials, Non-Cancer Therapeutics, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Protein/Pharma Production in Plants
Method for Production of Self-Replicating, Nucleic Acid-Loaded Virus-Like Particles in plants
Vaccines are an essential tool in preventing and controlling many diseases. Most approved vaccines are inactivated or live attenuated type, however, alternative platforms like mRNA and virus-like particles (VLPs) are being increasingly explored and approved because they generate potent immune responses with great safety profiles. VLPs are particularly...
Published: 8/7/2023   |   Inventor(s): Qiang Chen, Huafang Lai
Keywords(s):  
Category(s): Agriculture/Animal Health, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Vectors/Constructs/Plasmids, Protein/Pharma Production in Plants, Vaccines/Antimicrobials
Methods to Increase Genetic Transformation in Cyanobacterium
Cyanobacteria are model species for studying photosynthesis and recently have been gaining increased attention for their ability to produce renewable fuels and chemicals by harvesting solar energy and recycling carbon dioxide. Unfortunately, despite all the recent research and exciting achievements made regarding cyanobacteria, genetic transformation...
Published: 4/14/2023   |   Inventor(s): Bo Wang, Weiwen Zhang, Deirdre Meldrum
Keywords(s): Algae, Microalgae, Cyanobacteria, Biofuels Production, Bio-Technology, Plasmid, Vectors, Constructs
Category(s): Life Science (All LS Techs), Vectors/Constructs/Plasmids, Alternative Energy/Biofuels/Bioplastics/Algae
Novel Vectors which Spread from Cell-to-Cell in Plants
Plants are a promising platform for rapid production of biologics as they offer many advantages over traditional systems, including safety, speed, versatility and cost. Geminiviruses are a group of small plant viruses that have been studied and used extensively in such plant-based production systems. Because geminiviruses replicate in nuclei, their...
Published: 2/23/2023   |   Inventor(s): Hugh Mason, Andrew Diamos
Keywords(s):  
Category(s): Agriculture/Animal Health, Life Science (All LS Techs), Pharmaceuticals, Vectors/Constructs/Plasmids, Protein/Pharma Production in Plants
Modified Aminoglycoside based polymers
Gene delivery systems include both viral and non-viral carriers. The use of cationic polymers, such as aminoglycosides, as non-viral carriers has seen increased interest mainly due to their ease of synthesis, robust nature and gene delivery efficacies. Unfortunately, cationic polymers are also known for low gene expression and toxicity. Because of their...
Published: 2/23/2023   |   Inventor(s): Kaushal Rege, Bhavani Miryala, Thrimoorthy Potta
Keywords(s):  
Category(s): Biomaterials, Cancer Therapeutics, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Vectors/Constructs/Plasmids
Method to enhance immunogenicity of live typhoid vaccines and carriers
Live recombinant attenuated Salmonella-vectored vaccines hold great promise as a means to improve human health by generating long-lasting mucosal, humoral and cellular immunity against Salmonella and a variety of non-Salmonella pathogens at a low cost. Salmonella Typhimurium elicits a robust host immune response by targeting M cells present on the luminal...
Published: 2/23/2023   |   Inventor(s): Kenneth Roland, Amanda Tafoya (gonzales)
Keywords(s):  
Category(s): Life Science (All LS Techs), Vectors/Constructs/Plasmids, Vaccines/Antimicrobials
Modified Geminiviral Vectors to Reduce Cell Death & Enhance Expression
Plants are a promising platform for rapid production of biologics as they offer many advantages over traditional systems, including safety, speed, versatility and cost. And the demonstration of plant-made pharmaceuticals that have been glycoengineered to have authentic human N-glycans further underscores their promising potential. However, high accumulation...
Published: 2/23/2023   |   Inventor(s): Hugh Mason, Andrew Diamos
Keywords(s):  
Category(s): Agriculture/Animal Health, Pharmaceuticals, Protein/Pharma Production in Plants, Vectors/Constructs/Plasmids, Life Science (All LS Techs)
Photosynthetic Production of 3-Hydroxybutyrate from Carbon Dioxide
The market interest in bioproduction of chemicals and polymers is steadily growing, driven by sustainability concerns and increashttp://azte.technologypublisher.com/files/sites/ncs-m12-182,-m14-208l,-m14-232l.pdfed environmental awareness. However, most production technologies rely on petroleum or food crops as feedstocks. In the coming decades, materials...
Published: 2/23/2023   |   Inventor(s): Bo Wang, Weiwen Zhang, Deirdre Meldrum, David Nielsen
Keywords(s): Algae, Microalgae, Cyanobacteria, Biofuels Production, Bioplastic and Biopolymers, Bio-Technology, Cell Metabolism, Chemicals, Environmental, Food, Grain, Nutrition, Metabolic, Photosynthesis, Solar Energy, Synthesis
Category(s): Alternative Energy/Biofuels/Bioplastics/Algae, Life Science (All LS Techs), Vectors/Constructs/Plasmids
HIV Vaccination Compositions
Despite the success of antiretroviral treatments, there are still millions of new cases of human immunodeficiency virus (HIV) every year, with a higher prevalence in areas of the world with limited healthcare access. Vaccine strategies have been extensively studied and even developed to try to prevent or limit the spread of the virus. Current vaccination...
Published: 2/23/2023   |   Inventor(s): Tsafrir S Leket-Mor, Bertram Jacobs, Lydia Meador, Karen Kibler
Keywords(s): Bio-Technology, Therapeutics
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Protein/Pharma Production in Plants, Vectors/Constructs/Plasmids, Vaccines/Antimicrobials
Microbial Production of 2-Phenylethanol & 2-Phenylacetic Acid from Renewable Substrates
2-Phenylethanol is a naturally-occurring aromatic alcohol and key molecule used in the flavor and fragrance industries due to its floral, rose-like aroma. Additionally, 2PE has been considered as a potential biofuel or fuel additive due to its low volatility, high energy density and non-hygroscopic properties. Natural 2PE can be obtained from various...
Published: 2/23/2023   |   Inventor(s): David Nielsen, Michael Machas, Rebekah Mckenna
Keywords(s):  
Category(s): Life Science (All LS Techs), Vectors/Constructs/Plasmids, Alternative Energy/Biofuels/Bioplastics/Algae
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