Search Results - therapeutics+%3e+gastroenterology

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Targeting the Bile Acid Pathway to Treat Cardiometabolic Disease (UCLA Case No. 2024-146)
UCLA researchers from the Department of Medicine and Division of Cardiology have identified target enzymes involved in bile acid synthesis and developed methods to improve disease outcomes in fatty liver and atherosclerosis. BACKGROUND: Dietary fat is an essential, energy-dense nutrient necessary for survival. To support this, the intestinal system...
Published: 7/17/2025   |   Inventor(s): Thomas Vallim
Keywords(s):  
Category(s): Life Science Research Tools > Screening Libraries, Therapeutics > Gastroenterology, Therapeutics > Metabolism And Endocrinology, Life Science Research Tools > Research Methods, Therapeutics > Cardiovascular
Ingestible Device for Medical Interaction With the Gastrointestinal Tract and Surrounding Tissues (Case No. 2024-226)
Summary: UCLA researchers have conceptualized an ingestible, self-powered, and wireless capsule that can be used to effectively diagnose and treat gastrointestinal disorders. Background: Gastrointestinal (GI) disorders, including conditions like irritable bowel syndrome, Crohn’s disease, and gastroparesis, impact millions of people worldwide...
Published: 6/27/2025   |   Inventor(s): Wentai Liu, Ryan Kochis, Brian Arianpour, Alejandro Miron Jabalera
Keywords(s): Biosensor, brain-gut microbiome, Gastroenterology, Gastroenterology & Digestive Disease, gastrointestinal (GI) tract diseases, gut inflammation, Human Gastrointestinal Tract, minimally invasive device, Neuromodulation, wireless capsule endoscopy
Category(s): Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Gastroenterology, Software & Algorithms > Digital Health, Medical Devices > Monitoring And Recording Systems, Mechanical > Sensors, Chemical > Chemical Sensors, Life Science Research Tools > Screening Libraries
Gut Bacterial Detoxification of Methylmercury (UCLA Case No. 2023-188)
UCLA researchers from the Department of Integrative Biology and Physiology have developed a microbiome-based therapy for methylmercury detoxification, leveraging a genetically engineered probiotic that neutralizes methlymercury in the gut prior to systemic absorption with potential applications in acute detoxification, preventative healthcare, and environmental...
Published: 7/17/2025   |   Inventor(s): Elaine Hsiao
Keywords(s):  
Category(s): Therapeutics > Gastroenterology, Therapeutics > Metabolism And Endocrinology
Manipulating the Gut Microbiome To Modify Host Eating Behavior (UCLA Case No. 2024-181)
UCLA researchers from the Department of Integrative Biology & Physiology have identified aspects of gut microbiome metabolism that affect host eating behavior, leading to possible microbiome therapies for appetite regulation. BACKGROUND: The microbiome consists of all microbes within the human body and has recently been shown to influence human...
Published: 7/17/2025   |   Inventor(s): Elaine Hsiao
Keywords(s):  
Category(s): Therapeutics > Gastroenterology, Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology
Microbial Metabolites for Promoting Brain Health (UCLA Case No. 2024-196)
UCLA researchers in the Department of Integrative Biology and Physiology have developed a maternal supplementation with microbiome-dependent metabolites to promote growth and neurobehavioral health in children impacted by maternal protein undernutrition. BACKGROUND: Protein undernutrition poses a significant risk of childhood stunting, accompanying...
Published: 7/17/2025   |   Inventor(s): Elaine Hsiao
Keywords(s): Brain, brain health, growth defects, malnutrition, maternal supplementation, microbial metabolites, microbiome, neurobehavioral impairment, neurodevelopment, nutrition, protein undernutrition, stunting
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health
Creation of a Specified Probiotic Blend to Help with Weight Loss and Associated Metabolic Disease (UCLA Case No. 2023-258)
UCLA researchers in the Department of Medicine, Vatche and Tamar Manoukin Division of Digestive Diseases have developed a novel probiotic blend composed of two gut bacteria strains. This blend has the potential to be a safe supplement for treating food addiction, obesity, cognition, and other associated metabolic diseases in humans. BACKGROUND: Obesity...
Published: 7/17/2025   |   Inventor(s): Arpana Church
Keywords(s): bacterial strain, brain reward system, brain-gut microbiome, food addiction, food metabolism, gut-brain axis, Mental health, Metabolic Diseases, Nutraceuticals / Probiotics, nutritional supplement, obesity
Category(s): Therapeutics > Metabolism And Endocrinology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health
Compounds for Improved Psychological and Resilience Measures Associated with Physical Activity (UCLA Case No. 2022-272)
UCLA researchers from the Department of Medicine have identified microbiome and metabolic markers associated with high physical activity in an obese population, leading to possible therapies that may provide the positive effects of physical activity. BACKGROUND: It is known that physical activity has a multitude of beneficial effects on health. On...
Published: 7/17/2025   |   Inventor(s): Arpana Church
Keywords(s): Bacteria, Exercise, Gastroenterology & Digestive Disease, gut-brain axis, Human Gastrointestinal Tract, metabolomics, microbiome, MRI, Nutraceuticals / Probiotics, obesity, physical activity, prebiotics, Psychology
Category(s): Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health, Therapeutics > Metabolism And Endocrinology
Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic Diet (UCLA Case No. 2025-006)
UCLA researchers from the Department of Integrative Biology & Physiology have identified specific components of ketogenic diets that alter the microbiome and improve seizure resistance, providing valuable data to optimize diet treatments for refractory epilepsy. BACKGROUND: Refractory epilepsy, a disease characterized by uncontrolled seizures,...
Published: 7/17/2025   |   Inventor(s): Elaine Hsiao
Keywords(s): diet, dietary fiber, Epilepsy, gut, gut-brain axis, ketogenic diet, microbiome, pediatrics, seizure
Category(s): Therapeutics > Gastroenterology, Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology
Surgical Mesh Permanent Implant (Case No. 2023-109)
Summary: UCLA Researchers in the Department of Chemistry and Biochemistry have developed a bacterial nanocellulose (BNC) that exhibits promising biocompatibility and mechanical properties that can be used as a long-term treatment for medical conditions requiring surgical mesh devices. Background: Surgical mesh devices are medical devices used to...
Published: 2/14/2025   |   Inventor(s): Paul Weiss, Melina Mastrodimos, Maryam Badv
Keywords(s): Biologic Medical Product, Biomedical Engineering, biomedical implantation, Implant (Medicine), Medical Device, Medical Devices and Materials, Orthopedics and Prosthetics (O & P), Prosthesis, Prosthetics, Smart medical device, Surgical Instrument, surgical mesh, Surgical Tools, wearable medical device
Category(s): Medical Devices, Medical Devices > Surgical Tools, Materials, Materials > Functional Materials, Therapeutics, Therapeutics > Gastroenterology, Therapeutics > Urology, Therapeutics > Transplant
2013-778 MicroRNA Biomarkers and Therapeutic Targets for Colon Cancer and IBD
Summary Researchers at the UCLA Geffen School of Medicine have identified a novel set of biomarkers consisting of a microRNA and aftiphilin (AFTPH) as an effective means to distinguish between tissues with colon cancer and normal tissues. Other biomarkers within the set are linked specifically with inflammatory bowel disease. Background Colon cancer...
Published: 7/17/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics > Gastroenterology
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