Search Results - therapeutics+%3e+gastroenterology

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Microbial Metabolites for Promoting Brain Health (UCLA Case No. 2024-196)
UCLA researchers in the Department of Integrative Biology and Physiology have developed a maternal supplementation with microbiome-dependent metabolites to promote growth and neurobehavioral health in children impacted by maternal protein undernutrition. BACKGROUND: Protein undernutrition poses a significant risk of childhood stunting, accompanying...
Published: 12/12/2024   |   Inventor(s): Elaine Hsiao
Keywords(s): Brain, brain health, growth defects, malnutrition, maternal supplementation, microbial metabolites, microbiome, neurobehavioral impairment, neurodevelopment, nutrition, protein undernutrition, stunting
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health
Creation of a Specified Probiotic Blend to Help with Weight Loss and Associated Metabolic Disease (UCLA Case No. 2023-258)
UCLA researchers in the Department of Medicine, Vatche and Tamar Manoukin Division of Digestive Diseases have developed a novel probiotic blend composed of two gut bacteria strains. This blend has the potential to be a safe supplement for treating food addiction, obesity, cognition, and other associated metabolic diseases in humans. BACKGROUND: Obesity...
Published: 11/18/2024   |   Inventor(s): Arpana Church
Keywords(s): bacterial strain, brain reward system, brain-gut microbiome, food addiction, food metabolism, gut-brain axis, Mental health, Metabolic Diseases, Nutraceuticals / Probiotics, nutritional supplement, obesity
Category(s): Therapeutics > Metabolism And Endocrinology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health
Compounds for Improved Psychological and Resilience Measures Associated with Physical Activity (UCLA Case No. 2022-272)
UCLA researchers from the Department of Medicine have identified microbiome and metabolic markers associated with high physical activity in an obese population, leading to possible therapies that may provide the positive effects of physical activity. BACKGROUND: It is known that physical activity has a multitude of beneficial effects on health. On...
Published: 11/18/2024   |   Inventor(s): Arpana Church
Keywords(s): Bacteria, Exercise, Gastroenterology & Digestive Disease, gut-brain axis, Human Gastrointestinal Tract, metabolomics, microbiome, MRI, Nutraceuticals / Probiotics, obesity, physical activity, prebiotics, Psychology
Category(s): Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health, Therapeutics > Metabolism And Endocrinology
Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic Diet (UCLA Case No. 2025-006)
UCLA researchers from the Department of Integrative Biology & Physiology have identified specific components of ketogenic diets that alter the microbiome and improve seizure resistance, providing valuable data to optimize diet treatments for refractory epilepsy. BACKGROUND: Refractory epilepsy, a disease characterized by uncontrolled seizures,...
Published: 9/19/2024   |   Inventor(s): Elaine Hsiao
Keywords(s): diet, dietary fiber, Epilepsy, gut, gut-brain axis, ketogenic diet, microbiome, pediatrics, seizure
Category(s): Therapeutics > Gastroenterology, Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology
Surgical Mesh Permanent Implant (Case No. 2023-109)
Summary: UCLA Researchers in the Department of Chemistry and Biochemistry have developed a bacterial nanocellulose (BNC) that exhibits promising biocompatibility and mechanical properties that can be used as a long-term treatment for medical conditions requiring surgical mesh devices. Background: Surgical mesh devices are medical devices used to...
Published: 10/7/2024   |   Inventor(s): Paul Weiss, Melina Mastrodimos, Maryam Badv
Keywords(s): Biologic Medical Product, Biomedical Engineering, biomedical implantation, Implant (Medicine), Medical Device, Medical Devices and Materials, Orthopedics and Prosthetics (O & P), Prosthesis, Prosthetics, Smart medical device, Surgical Instrument, surgical mesh, Surgical Tools, wearable medical device
Category(s): Medical Devices, Medical Devices > Surgical Tools, Materials, Materials > Functional Materials, Therapeutics, Therapeutics > Gastroenterology, Therapeutics > Urology, Therapeutics > Transplant
SYNERGISM BETWEEN PROTON PUMP INHIBITORS AND A GI PEPTIDE IN REDUCING ACID SECRETION
Case 2000-093UCLA researchers in the Department of Medicine have discovered a novel method to improve the efficacy of proton pump inhibition. BACKGROUND:A vast number of pathological conditions are characterized by over-secretion of gastric acid, such as Zollinger/Ellison syndrome (ZES), gastroesophageal reflux disease (GERD), peptic ulcer disease,...
Published: 7/19/2023   |   Inventor(s): Joseph Pisegna
Keywords(s): Gastroenterology & Digestive Disease, Renal, Therapeutics & Vaccines
Category(s): Therapeutics > Gastroenterology, Therapeutics > Renal
2013-778 MicroRNA Biomarkers and Therapeutic Targets for Colon Cancer and IBD
Summary Researchers at the UCLA Geffen School of Medicine have identified a novel set of biomarkers consisting of a microRNA and aftiphilin (AFTPH) as an effective means to distinguish between tissues with colon cancer and normal tissues. Other biomarkers within the set are linked specifically with inflammatory bowel disease. Background Colon cancer...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics > Gastroenterology
2019-519 MICROBIOME-BASED MODULATION OF SENSORY NEURONAL ACTIVITY
UCLA researchers in the Department of Integrative Biology and Physiology have begun to elucidate the molecular pathways for communication between the gut microbiota and the brain, serving as potential therapeutic targets for the treatment of various neurological diseases.BACKGROUND: The gut microbiota is recognized as an important regulator of brain...
Published: 7/16/2024   |   Inventor(s): Elaine Hsiao
Keywords(s): Diagnostic Markers & Platforms, Gastroenterology & Digestive Disease
Category(s): Therapeutics > Gastroenterology
2019-520 MATERNAL GUT MICROBIOTA REGULATION OF NEURODEVELOPMENT AND ADULT SENSORY BEHAVIOR
UCLA Researchers in the Department of Integrative Biology and Physiology have determined the necessary role for maternal gut microbes in neurodevelopment and that select microbes may prevent abnormal neurodevelopmental phenotypes.BACKGROUND: The gastrointestinal tract and brain are intimately linked, and in the past decade there have been increasing...
Published: 2/16/2024   |   Inventor(s): Elaine Hsiao, Helen Vuong
Keywords(s): Diagnostic Markers & Platforms, Gastroenterology & Digestive Disease
Category(s): Therapeutics > Gastroenterology
2000-093 Novel Diuretic and Inhibitor of Gastric Acid Secretion
Background A wide number of pathological conditions are characterized by over-secretion of gastric acid, such as Zollinger/Ellison syndrome (ZES), gastroesophageal reflux disease (GERD), peptic ulcer disease, duodenalulcers, atrophic gastritis, esophagitis, and the like. Conditions such as ZES and peptic ulcers, in particular, can have serious complications...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics > Gastroenterology
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