Search Results - therapeutics+%3e+autoimmune

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Hemodynamics Driven Magnetoelastic Vascular Graft (Case No. 2025-124)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel magnetoelastic vascular graft to provide real-time, wireless, and continuous stenosis monitoring. TITLE: Hemodynamics Driven Magnetoelastic Vascular Graft Background: Vascular grafts are commonly used to restore blood flow in patients with blocked or damaged blood...
Published: 6/12/2025   |   Inventor(s): Jun Chen, Song Li, Guorui Chen
Keywords(s): cardiovascular monitoring, Diagnostic Platform Technologies (E.G. Microfluidics), hemodynamic monitoring, Hemodynamics, magnetoelastic sensor, Medical diagnostics, Vascular therapy
Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Medical Devices > Monitoring And Recording Systems, Therapeutics > Autoimmune, Therapeutics > Immunology And Immunotherapy, Therapeutics > Transplant, Therapeutics > Hematology, Therapeutics > Cardiovascular
Saliva Anti-SSA/Ro IgA1 Differentiates Sjögren’s from Non-Sjögren’s Syndrome Patients (UCLA Case No. 2023-292)
UCLA researchers in the Department of Dentistry have developed a novel methodology to accurately differentiate patients with Sjögren’s Disease from non-Sjögren’s Disease patients by monitoring saliva IgA1 forms, enabling more accurate tracking of disease progression. BACKGROUND: The presence and detection of autoantibodies within...
Published: 3/14/2025   |   Inventor(s): David Wong
Keywords(s):  
Category(s): Therapeutics > Autoimmune, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Therapeutics > Ophthalmology
Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)
Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...
Published: 2/14/2025   |   Inventor(s): Michael Teitell, Owen Witte, Thomas Zangle, Daina Burnes Linton
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment
A novel ER beta ligand prodrug to treat neurodegenerative conditions (UCLA Case No. 2017-168)
Researchers from the Department of Neurology and the Department of Chemistry and Biochemistry at UCLA have developed a novel ERβ ligand prodrug that is structurally designed to confer neuroprotection in neurodegenerative conditions (multiple sclerosis, Alzheimer’s disease, and cognitive deficits of menopause in otherwise healthy women). BACKGROUND: Multiple...
Published: 2/14/2025   |   Inventor(s): Rhonda Voskuhl, Michael Jung
Keywords(s): Autoimmune, Cns, Therapeutics & Vaccines
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Autoimmune, Therapeutics
2019-839 Self-Modulating T Cells with Robust Anti-Tumor Efficacy and Reduced Propensity for Triggering Severe Cytokine Release Syndrome
SUMMARY: Researchers from UCLA’s Department of Microbiology, Immunology and Molecular Genetics have developed methods for generating self-modulating CAR-T cells which retain robust anti-tumor function whilst having reduced adverse side effects relating to cytokine release syndrome. BACKGROUND: The immunotherapy approach of T-cell engineering...
Published: 2/14/2025   |   Inventor(s): Yvonne Chen
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Autoimmune, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
2020-152 Method to Clone Human T Cell Receptors (TCRs) from Single Lymphocytes Based on Functional Profiling
SUMMARY: UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel method to clone human T cell receptors from single lymphocytes. BACKGROUND: Immunotherapy is a growing therapy type for the treatment of disease, especially cancer, by activating or repressing the immune system. One major type...
Published: 2/14/2025   |   Inventor(s): Owen Witte, Jami Witte, Pavlo Nesterenko
Keywords(s):  
Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing
2022-057 NEW TREATMENT FOR SJOGREN'S SYNDROME
SUMMARY: UCLA researchers in the Department of Molecular and Medical Pharmacology have identified a novel and safe therapeutic to ameliorate symptoms for the autoimmune disorder, Sjögren’s Syndrome. BACKGROUND: Sjögren’s syndrome (SS) is an autoimmune disorder that affects over 4 million people in the United States. Most commonly,...
Published: 2/14/2025   |   Inventor(s): Daniel Kaufman
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Autoimmune, Therapeutics > Inflammation And Inflammatory Diseases
2021-075 A New Drug Class Inhibits Illness and Death Due to Coronavirus Infection in Mice
Researchers from UCLA’s Department of Molecular and Medical Pharmacology have identified and validated a therapeutic target and an accompanying drug class which ameliorates illness and death due to Coronavirus infection. BACKGROUNDThere remains an urgent need for treatments that can reduce the symptoms for those infected by SARS-CoV-2, its future...
Published: 2/14/2025   |   Inventor(s): Daniel Kaufman, Jide Tian
Keywords(s): Immunotherapy
Category(s): Therapeutics > Autoimmune, Therapeutics > Cardiovascular
2021-005 Liver-Targeting Tolerogenic Nanoparticles Encapsulating an Allergen T-Cell Epitope Impacts Eosinophilic Airway Inflammation with Comparable Efficacy as Pharmaceutical Tolerogenic Nanoparticles
UCLA researchers in the David Geffen School of Medicine and CNSI have developed a nanoparticle that induces antigen tolerance for use in treatment of allergy and autoimmune diseases. BACKGROUND: When the body’s immune overreacts against environmental allergens or falsely recognizes the body’s own molecular components as foreign, the results...
Published: 2/14/2025   |   Inventor(s): Andre Nel
Keywords(s): Autoimmune, Drug Delivery, Materials, Nanoparticles, Nanotechnology
Category(s): Materials > Nanotechnology, Therapeutics > Autoimmune, Therapeutics > Inflammation And Inflammatory Diseases
2016-592 CATALYTIC MICRORNA ANTAGONISTS
Catalytic MicroRNA AntagonistsSUMMARYUCLA researchers in the Department of Biological Chemistry have developed a novel approach for miRNA inhibition.BACKGROUNDMicro RNA (miRNA) are short, 22 nucleotide RNA sequences. They play a critical role in post-transcription gene regulation and their mis-regulation is associated with different diseases such as...
Published: 2/14/2025   |   Inventor(s): Feng Guo
Keywords(s): Autoimmune, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Autoimmune
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