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Bioactive Nanoparticles for an Osteoarthritis Therapeutic
Neutralizes Reactive Oxygen Species to Reduce Oxidative Stress in Osteoarthritic TissueThese nanoparticles break down the reactive oxygen species (ROS) generated during joint trauma and inflammation, thereby mitigating oxidative stress in order to treat or prevent osteoarthritis (OA) as well as other inflammatory diseases. Oxidative stress plays a central...
Published: 6/27/2021   |   Inventor(s): Blanka Sharma, Isaac Adjei, Shreedevi Kumar
Keywords(s): Maganese Disorder, MNO2, Nanoparticle, osteoarthritis, Oxidative stress, PEG, Poly ethylene glycol, Reactive Oxygen Species, ROS
Category(s): Technology Classifications > Human Health Care > Therapeutics
Photocurable Poly(ethylene Glycol) as a Bioink for the Inkjet 3D Pharming of Hydrophobic Drugs
UC Case No. 2018-197SUMMARY: UCLA researchers in the Department of Bioengineering have developed a novel inkjet 3D pharming technique that is fast, customizable, and compatible with hydrophobic drugs. BACKGROUND: 3D pharming is an innovative technique that combines 3D printing and 2D material deposition to create personalized drug tablets that...
Published: 7/19/2023   |   Inventor(s): Benjamin Wu, Chase Linsley
Keywords(s): Drug Delivery, Other Polymers, PEG
Category(s): Platforms > Drug Delivery > Other Polymers, Platforms > Drug Delivery > PEG
2017-701 Nanoparticle-Enabled Delivery of Large Plasmid DNA for Gene Therapy of Duchenne Muscular Dystrophy and Cancer
Polyrotaxane Nanoparticles for Delivery of Large Plasmid DNA in Duchenne Muscular DystrophySUMMARYUCLA researchers have designed, synthesized, and validated a polyrotaxane nanocarrier for targeted delivery of large plasmids for gene therapy applications for treatment of Duchenne muscular dystrophy and cancer.BACKGROUNDRapid development of genome/epigenome...
Published: 7/19/2023   |   Inventor(s): Melissa Spencer, April Pyle, Huan Meng, Courtney Young, Xiangsheng Liu
Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Genetic Disease, Life Science Research Tools, Medical Devices and Materials, Musculoskeletal Disease, Nanoparticles, Oncology, PEG, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Medical Devices, Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing, Therapeutics > Musculoskeletal Disease, Platforms > Drug Delivery > Nanoparticles, Therapeutics > Oncology, Platforms > Drug Delivery > PEG