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Search Results - ros
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Iodonium Analogs as Inhibitors of NADPH Oxidases and other Flavin Dehydrogenases and their Use for Treating Cancer
Abstract: Diverse human cancers like colorectal, pancreatic, ovarian, melanoma, and pre-cancers express NADPH oxidases (NOX) at high levels. Reactive oxygen species (
ROS
) produced from metabolic reactions catalyzed by NOX in tumors are essential to the tumor’s growth. Though drugs that inhibit ROS production by NOX could be effective against a variety...
Published: 4/8/2024
|
Inventor(s):
James Do
ros
how
,
Prabhakar Risbood
,
Jaimo Lu
,
Krishnendu Roy
,
Md Tafazzai Hossian
Keywords(s):
Diphenylene Iodonium
,
Di-thienyl-iodonium
,
Do
ros
how
,
DPI
,
DTI
,
Flavin Dehydrogenases
,
NADPH oxidases
,
NOX
,
Pre-cancerous Lesions
,
Reactive Oxygen Species
,
ROS
Category(s):
TherapeuticArea > Immunology
,
Application > Therapeutics
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
Nitric Oxide Based Therapeutics for the Treatment of Lung Cancer
Abstract: Nitric oxide (NO) has a broad spectrum of actions in physiological and pathological processes. NO-donor drugs have shown therapeutic effect in several cancer types by inducing apoptosis but the concentrations required have suggested limited clinical applicability. For cancers such as non-small cell lung cancer where most therapies are not...
Published: 5/22/2024
|
Inventor(s):
Anna Maciag
,
Harinath Chakrapani
,
Joseph Saavedra
,
Lucy Anderson
,
Larry Keefer
Keywords(s):
Diazeniumdiolate
,
nitric oxide
,
NO
,
prodrug
,
Reactive Oxygen Species
,
ROS
Category(s):
TherapeuticArea > Oncology
,
Collaboration Sought > Licensing
,
Application > Therapeutics
Bioactive Nanoparticles for an Osteoarthritis Therapeutic
Neutralizes Reactive Oxygen Species to Reduce Oxidative Stress in Osteoarthritic TissueThese nanoparticles break down the reactive oxygen species (
ROS
) generated during joint trauma and inflammation, thereby mitigating oxidative stress in order to treat or prevent osteoarthritis (OA) as well as other inflammatory diseases. Oxidative stress plays a central...
Published: 6/27/2021
|
Inventor(s):
Blanka Sharma
,
Isaac Adjei
,
Shreedevi Kumar
Keywords(s):
Maganese Disorder
,
MNO2
,
Nanoparticle
,
osteoarthritis
,
Oxidative stress
,
PEG
,
Poly ethylene glycol
,
Reactive Oxygen Species
,
ROS
Category(s):
Technology Classifications > Human Health Care > Therapeutics
Super Sensitive Sensor For The Detection Of Hydroxyl Free Radicals in Food
Project ID: D2020-04 Background: Detection of free radicals (
ROS
) is vital in maintaining food safety as the estimated economic damage caused by the impact on food safety is $7 billion per year in the US. The presence of ROS causes devastating effects on the food as it leads to oxidation of proteins, breakage of oligonucleotides, or irreparable altering...
Published: 5/9/2024
|
Inventor(s):
Keywords(s):
Cerium Oxide
,
Hydroxyl Free Radical
,
Reactive oxygen species
,
ROS
,
Sensor
Category(s):
Diagnostics
,
Sensor
Super Sensitive Sensor for the Detection of Hydroxyl Free Radicals
Project ID: D2020-04 Reactive oxygen species (
ROS
) are well known for their extreme reactivity. The impact of free radicals on medical and clinical fields is critical as hydroxyl radicals (OH) can be used as biomarkers for the detection of aging, cancer, Alzheimer’s, and Parkinson’s diseases. Because certain types of free radicals are known...
Published: 5/9/2024
|
Inventor(s):
Ana Alba Rubio
,
Dong Shik Kim
,
Surachet Duanghathaipornsuk
Keywords(s):
Cerium Oxide
,
Hydroxyl Free Radical
,
Reactive oxygen species
,
ROS
,
Sensor
Category(s):
Sensor
,
Diagnostics