Search Results - nongjian+(nj)+tao

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Nanoparticles for Precise & Targeted Treatment of Neurological Conditions
Problem: Acute ischemic stroke (AIS) is the second leading cause of death worldwide, affecting around 600,000 Americans annually. However, pharmacological treatment of AIS is difficult due to ineffective and nonspecific targeting to blood brain barrier epitopes via intravenous administration. Over 100 drugs have been tried and failed in clinical trials...
Published: 2/20/2025   |   Inventor(s): Oscar Marcos Contreras, Jacob Brenner, Vladimir Muzykantov, Jia Nong, Patrick Glassman, Drew Weissman, Sahiley Reyes-Esteves
Keywords(s): Drug Delivery, Inflammation, Nanotechnology, Neurology
Category(s): Technology Classifications > Therapeutics
System for Single Protein Imaging and Analysis
The ability to determine molecular binding is crucial in drug screening, biomarker detection, and understanding biological processes at the molecular level. Many methods for looking at binding kinetics, such as liquid chromatography, mass spectrometry, western blot, etc., are time consuming, cause protein fragmentation/denaturation and do not allow...
Published: 2/13/2025   |   Inventor(s): Nongjian (nj) Tao, Shaopeng Wang, Pengfei Zhang
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Imaging
Rapid Digital Antimicrobial Susceptibility Testing
Antibiotic resistance has become a significant public health threat, causing billions of healthcare-related costs as well as 2 million hospitalizations and 23,000 deaths annually in the US alone. Clinical treatment of bacterial infections, especially in acute cases of sepsis, requires multiple steps, including antibiotic susceptibility testing (AST)....
Published: 2/13/2025   |   Inventor(s): Nongjian (nj) Tao, Fenni Zhang, Shaopeng Wang
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs), Computing & Information Technology
Sensors for Continuous and Quantitative Tracking of Airborne Chemicals
Chemical sensors are useful in detecting many airborne chemicals for monitoring air quality, studying environmental health, and protecting people from harmful chemical exposures. Major efforts have been made to develop low cost and high performance chemical sensors. Electrochemical and metal oxide semiconductors are widely used airborne chemical sensors,...
Published: 2/13/2025   |   Inventor(s): Nongjian (nj) Tao, Chenwen Lin, Di Wang
Keywords(s):  
Category(s): Chemical/Biological Sensors, Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs)
A Surface Impedance Imaging Technique
Surface or interfacial impedance spectroscopy has been established as a powerful technique for many applications, ranging from electrochemistry and corrosion analysis to biochips and biosensors. Most applications utilize a single or an array of electrodes and an electrical instrument to perform impedance measurement and analysis, which does not have...
Published: 2/13/2025   |   Inventor(s): Nongjian (nj) Tao, Kyle Foley
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
Colorimetric Sensors for Multiplexed Detection
Colorimetry is a well-known and widely used sensing platform that detects a color change associated with a reaction between a target chemical and sensing materials. Colorimetric sensors are useful in many applications including sensing toxic chemicals in air as well as detecting biomarkers in breath, urine, blood and other types of body fluids. In multiplexed...
Published: 2/13/2025   |   Inventor(s): Nongjian (nj) Tao, Di Wang
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Chemical/Biological Sensors, Medical Diagnostics/Sensors, Semiconductors, Materials & Processes, Intelligence & Security
Devices and Methods for Sensing Nitric Oxides
Nitric species such as nitric oxides are important environmental pollutants as well as key breath biomarkers of respiratory diseases. A chemical sensor that can quickly, selectively and sensitively detect these analytes will find applications not only in environmental monitoring, but also as a non-invasive medical diagnosis and management device. Current...
Published: 2/13/2025   |   Inventor(s): Nongjian (nj) Tao, Erica Forzani, Xiaojun Xian, Francis (tsing) Tsow
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Environmental, Life Science (All LS Techs), Medical Devices
Label-Free Detection, Identification & Quantification of Single Proteins
Proteins play a prominent role in most cellular functions and many biological processes. They are also important as potential therapeutics, drug targets and biomarkers. The size or conformation and subsequent activity of proteins is regulated by both structure and electrostatic properties. Common techniques for measuring the electrostatic properties...
Published: 2/13/2025   |   Inventor(s): Nongjian (nj) Tao, Guangzhong Ma
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Diagnostic Assays/Devices, Imaging
Time-Resolved Digital Immunoassay
Detection, identification and quantification of molecular biomarkers, such as proteins, peptides, exosomes, hormones, neurotransmitters, metabolites and nucleic acids, are critical to disease diagnosis and progression monitoring. While there are multiple approaches to biomarker analyses, the most validated and well-established is ELISA. Although powerful,...
Published: 2/13/2025   |   Inventor(s): Nongjian (nj) Tao, Wenwen Jing
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools, Genomic Assays/Reagents/Tools
Multifunctional nanoparticles for prevention and treatment of atherosclerosis
PAGE TITLE Overview PAGE SUMMARY Atherosclerosis is a chronic inflammatory disease of the artery wall and a major cause of cardiovascular disease, the leading cause of death in the US and many developed economies. The inflamed cells release free radicals that produce a strong local oxidative environment where low density lipoproteins (LDLs) are...
Published: 2/19/2025   |   Inventor(s): Yinghui Zhong, Jia Nong, Zhicheng Wang
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Medical Devices, Diagnostics & Biosensors, Biomaterials & Drug Delivery
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