Search Results - conformation

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METHODS RELATED TO AN ALTERNATIVE CONFORMATION OF THE SARS-COV-2 SPIKE PROTEIN
METHODS RELATED TO AN ALTERNATIVE CONFORMATION OF THE SARS-COV-2 SPIKE PROTEIN Researchers at UC Berkeley have developed methods to probe the conformational landscape of the SARS-CoV-2 Spike protein in the prefusion and ligand binding variations. The Spike protein from SARS-CoV-2 is the primary target for current vaccines against COVID-19 and is...
Published: 7/27/2023   |   Inventor(s): Susan Marqusee, Shawn Costello, Sophie Shoemaker
Keywords(s): Conformation, Mass Spectrometry, Modeling, Spike Protein, Structure
Category(s): Technology Classifications > Biology
Conformation Dependent Anti-major Outer Membrane Protein (MOMP) Monoclonal Antibody BD5
A murine hybridoma expressing mAb BD3 was found to react with a conformationally dependent epitope on the chlamydial Major Outer Membrane Protein (MOMP), a primary target of neutralizing antibodies and vaccine development. The BD3 neutralized the in vitro infectivity of C. trachomatis serovars B, Ba, D, E, L2. It is useful for verifying the correct...
Published: 10/28/2024   |   Inventor(s): Harlan Caldwell
Keywords(s): Against, ANTIBODY, Anti-major, B, ba, BD5, Chlamydia, CONFORMATION, Correct, D, Dependent, e, Hybridoma, L2, Listed LPM Thalhammer-Reyero as of 4/15/2015, Mab, MEMBRANE, MOMP, monoclonal, OUTER, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, RM, SEROVARS, TRACHOMATIS, USEFUL, vaccines, Verifying, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Recombinant Stabilized Prefusion Protein of Respiratory Syncytial Virus for Use as a Subunit Vaccine
The invention, a stabilized recombinant prefusion F protein (pre F), is a candidate subunit vaccine for Respiratory Syncytial Virus (RSV). Pre-F is stabilized in the prefusion conformation and displays epitopes not present in postfusion F protein. Several potent RSV neutralizing antibodies bind pre F, but not postfusion F. Therefore, immunization...
Published: 10/28/2024   |   Inventor(s): Jason Gorman, Gilad Ofek, Marie Pancera, Mallika Sastry, Sanjay Srivatsan, Yongping Yang, Lei Chen, Cinque Soto, Tongqing Zhou, Barney Graham, Peter Kwong, Masaru Kanekiyo, Michael Joyce, Baoshan Zhang, Guillaume Stewart-Jones, Jeffrey Boyington, Man Chen, Gwo-Yu Chuang, Ivelin Georgiev, Jason McLellan
Keywords(s): CONFORMATION, DC5BXX, DC5XXX, DCXXXX, DXXXXX, F, GLYCOPROTEIN, Listed LPM Thalhammer-Reyero as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Prefusion, PrefusionConformation, RSV, Stabilization, Structure-based, Vaccine, VLXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease