Search Results - roger+giese

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Satellite-MALDI of Nucleic Acids
INV-18071 Background DNA and RNA structural analysis provides useful information for drug discovery, disease diagnosis, and clinical research. Currently, used detection techniques include liquid chromatography‑mass spectrometry (LC/MS), antibody-based tests such as ELISA and Ames tests. However, these tests are time-consuming, expensive, less accurate,...
Published: 10/15/2024   |   Inventor(s): Roger Giese, Poguang Wang
Keywords(s):  
Category(s): -Cancer, Technology Classifications > 1. Life Science, Diagnostics, Technology Classifications > 1. Life Science > Biotechnology
Photo-Cation Enhanced Detection
gn:justify"> Background There are certain limitations and challenges posed by the use of mass spectrometry for analysis of small organic molecules in complex samples. Among the limiting factors are the requirement for multiple procedures and/or instrumentation, use of high temperatures, lack of sensitivity, and incomplete detection. High temperatures...
Published: 10/15/2024   |   Inventor(s): Roger Giese, Pushkar Kulkarni
Keywords(s): Analytical Chemistry
Category(s): -Chemistry
DNA Adductomics by Mass Tag Prelabeling
Background DNA adducts are damaged nucleotides in DNA as a consequence of its exposure to genotoxic agents or conditions. Measurement of multiple DNA adducts in a single procedure is referred to as “DNA adductomics”. In the leading analytical technique for this purpose, typically the following sequence of steps takes place starting with...
Published: 10/15/2024   |   Inventor(s): Roger Giese, Poguang Wang
Keywords(s): Cancer, cancer prevention, DNA adduct, Mass Spectrometry, Mass tags, personalized medicine
Category(s): -Cancer
On-Surface Mass Tagging
INV-19002 Background An array of detection techniques are used to measure sorbed substances on surfaces. Mass spectrometry is the preferred method since it can provide both qualitative and quantitative information. Technology Overview In this proposed technique, heat, plasma, electrospray, or organic solvent can be used to recover a sorbed...
Published: 10/15/2024   |   Inventor(s): Roger Giese, Pushkar Kulkarni, Poguang Wang
Keywords(s):  
Category(s): Technology Classifications > 2. Physical Science > Environmental/Clean tech
Hydrogel with Initiator-Tightened Surface
INV- 1007 Background The absence of highly porous, uniformly nanoporous surfaces places limitations on handling, fractionating, extracting, recovering and concentrating aqueous and nonaqueous samples of chemicals and biological substances, both soluble and insoluble. For example, if the surface is not highly porous, then a process that depends on...
Published: 10/15/2024   |   Inventor(s): Roger Giese, Gang Shao
Keywords(s): Analytical Chemistry, Chemistry, Drug Discovery & Development, Research Tool, Screening Tool
Category(s): -Analytical Chemistry, -Chemistry, -Materials, Technology Classifications > 2. Physical Science > Lab tech/equipment