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Search Results - m+rosovitz
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DNA as an Antimicrobial Agent for Preventing Neisseria Gonorrhoeae Infection
This invention encompasses a series of DNA-based antimicrobial compounds that prevent transmission of Neisseria gonorrhoeae (Ngo) during sexual intercourse and possibly treat an extant Ngo infection, alone or in combination with antibiotics, while leaving commensals unharmed. These DNA molecules are effective against low-passage antibiotic sensitive...
Published: 9/25/2024
|
Inventor(s):
Maria Rendon
,
Magdalene So
Keywords(s):
Category(s):
Technology Classifications > Healthcare Portfolios > Reproductive Health: Obstetrics & Gynecology
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Nozzle and Dispenser for Time-Resolved Electron Microscopy Structural Studies
Background In the realm of electron microscopy, there is a burgeoning interest in investigating dynamic processes like protein folding and molecular interactions in real time. However, traditional methods mostly yield static images, which makes it difficult to investigate fast-moving dynamic occurrences. One of the main challenges is that protein samples...
Published: 6/4/2024
|
Inventor(s):
Peter Wiktor
,
Abhik Manna
,
Petra Fromme
,
Alexandra Ros
Keywords(s):
Category(s):
Physical Science
,
Bioanalytical Assays, Chemistries & Devices
,
Advanced Materials/Nanotechnology
Droplet Injector for Time-Resolved Crystallography with XFELs
Background Protein X-ray crystallography has become one of the most successful structural biology techniques since the first three-dimensional structure of myoglobin, a protein, was revealed. Many important scientific discoveries have been made using X-ray crystallography, including understanding insulin’s mechanism of action, mass production...
Published: 1/19/2024
|
Inventor(s):
Alexandra Ros
,
Diandra Doppler
,
Mukul Sonker
,
Ana Egatz-Gomez
,
Richard Kirian
,
Sahba Zaare
,
Abhik Manna
,
Konstantinos Karpos
,
Roberto Alvarez
Keywords(s):
Category(s):
Physical Science
,
Bioanalytical Assays, Chemistries & Devices
,
Imaging
Laser Capture Microdissection (LCM) Microfluidic Platform for Single-Cell Proteomic Analysis
Single-cell proteomics is an emerging field for proteomic analyses of individual cells. Single-cell genomic analyses have greatly expanded our understanding of cell heterogeneity and disease progression; however, protein identification and quantitative cell-to-cell variation provide a deeper level of understanding of the biological regulators in the...
Published: 6/28/2023
|
Inventor(s):
Alexandra Ros
,
Jorvani Cruz Villarreal
,
Ana Egatz-Gomez
,
Todd Sandrin
,
Paul Coleman
Keywords(s):
Category(s):
Proteomic Assays/Reagents/Tools
,
Neurodegenerative Disease Technologies
,
Life Science (All LS Techs)
,
Bioanalytical Assays, Chemistries & Devices
Recombinant Modified
Bacillus anthracis
Protective Antigen for Use in Vaccines
This invention relates to improved methods of preparing Bacillus anthracis protective antigen (PA) for use in vaccines. PA is a secreted, non-toxic protein with a molecular weight of 83 KDa. PA is a major component of the currently licensed human vaccine (Anthrax Vaccine Adsorbed, AVA). Although the licensed human vaccine has been shown to be effective...
Published: 10/28/2024
|
Inventor(s):
John Robbins
,
Stephen Leppla
,
Rachel Schneerson
,
M Rosovitz
Keywords(s):
Anthrax
,
ANTIGEN
,
Chromosome 18 ring
,
Chymotrypsin-Sensitive
,
CREATION
,
Cutaneous anthrax
,
DAXXXX
,
DBXXXX
,
DC4XXX
,
DC6XXX
,
DCXXXX
,
DDXXXX
,
DELETIONS
,
DXXXXX
,
Furin-Cleavage...
,
Loop
,
MOLECULE
,
Protective
,
R 18
,
recombinant
,
rPA
,
STABLE
,
UAXXXX
Category(s):
Application > Diagnostics
,
TherapeuticArea > Rare / Neglected Diseases
,
Application > Research Materials
,
TherapeuticArea > Infectious Disease
,
Application > Therapeutics
,
Application > Vaccines
Modular 3D Printed Devices for Sample Delivery
Background Microfluidic devices are commonly used in serial crystallography applications. In most serial crystallography experiments, the sample molecules are formed into droplets through electrical stimulation, then injected into a focused beam of electrons or X-rays so their structure can be analyzed. The various components of the experiment...
Published: 2/23/2023
|
Inventor(s):
Alexandra Ros
,
John Spence
,
Diandra Doppler
,
Garrett Nelson
,
Richard Kirian
,
Reza Nazari
,
Ana Egatz-Gomez
,
Mukul Sonker
,
Mohammad Rabbani
Keywords(s):
Category(s):
Physical Science
,
Bioanalytical Assays, Chemistries & Devices
Intraocular Optic Capture Device (IOCD)
Competitive Advantages Made of FDA approved material Minimal incision required Compatible with single-piece IOL’s including premium lenses Allows re-fixation of dislocated toric IOL’s Summary A device called Intraocular Optic Capture Device (IOCD) was developed by USF researchers for IOL re-fixation. The first of its kind, this...
Published: 7/18/2023
|
Inventor(s):
Jason So
Keywords(s):
Health Tech
,
Medical Devices
,
Optics and Imaging
Category(s):
Technology Classifications > Medical > Ophthalmology
,
Technology Classifications > Medical > Medical Devices
,
Technology Classifications > Medical
Use of DNA Containing Specific Sequences to Prevent Neisseria Gonorrhoeae Infection
This invention encompasses an antimicrobial that can treat disease caused by the pathogen Neisseria Gonorrhoeae (Ngo). The compounds described can be incorporated into commercially available personal lubricants for individual use. Background: N. gonorrhoeae (Ngo) causes over 160 million new cases of gonorrhea each year globally; in 2018, it caused...
Published: 4/3/2023
|
Inventor(s):
Magdalene So
,
Maria Rendon
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Genes and Polypeptides of Neisseria Musculi that can be used to Evaluate Vaccines and Anti-Bacterial Compounds against Infection by Pathogenic Neisseria Species
A set of Neisseria musculi (Nmus) genes have been identified which promote Nmus infection and persistence in its natural host, the mouse. These genes have never been described before, so the in-host function of their encoded proteins is unknown. These genes are present in the human pathogenic Neisseria, N. meningitidis and N. gonorrhoeae. These genes...
Published: 4/3/2023
|
Inventor(s):
Magdalene So
,
Katherine Rhodes
,
Maria Rendon
Keywords(s):
Category(s):
Technology Classifications > Healthcare Portfolios > Infectious Diseases
,
Technology Classifications > Life Sciences > Therapeutics
Dielectrophoretic Length-Selective Separation of Single-Walled Carbon Nanotubes
Background Single-walled carbon nanotubes (SWNTs) possess unique physical, optical, and electrical properties with great potential for future nanoscale device applications. Common synthesis procedures yield SWNTs with large length polydispersity and varying chirality. Electrical and optical applications of SWNTs often require specific lengths,...
Published: 8/10/2023
|
Inventor(s):
Alexandra Ros
,
Mohammad Rabbani
,
Christoph Schmidt
Keywords(s):
Category(s):
Physical Science
,
Advanced Materials/Nanotechnology
,
Semiconductors, Materials & Processes
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