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Glycoprotein engineering for hemorrhagic fever virus vaccines

Scientists stabilized the Crimean-Congo hemorrhagic fever virus glycoprotein complex to study its structure and develop a potential vaccine. This complex elicits an immune response and sheds light on the virus's entry mechanism. Background Crimean-Congo hemorrhagic fever virus (CCHFV) is a serious threat to human health, with mortality rates ranging...

Published: 3/3/2025 | Inventor(s): Jason McLellan, Elizabeth McFadden

Keywords(s):

Category(s): Life sciences > Therapeutics > Vaccines

Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47

A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis. Problem: Phagocytosis of ‘self’ cells is generally inhibited by a key macrophage checkpoint interaction between SIRPα on the macrophage and...

Published: 2/27/2025 | Inventor(s): Dennis Discher, Jason Andrechak, Lawrence Dooling

Keywords(s): Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology

Category(s): Technology Classifications > Therapeutics

Laser apparatus for micro-volume tissue excision

This technology uses a laser to remove tiny pieces of tissue for analysis. The laser is shaped into a ring and can be combined with cooling techniques to minimize damage. Background The traditional histopathology workflow, while considered the gold standard for tissue diagnosis, suffers from several limitations. These include the invasiveness of biopsies,...

Published: 1/8/2025 | Inventor(s): Thomas Milner, James Tunnell, Jason King, Nitesh Katta

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Category(s): Life sciences > Medical technology > Medical devices, Life sciences > Medical technology

Nepenthes GDSL Lipase to Treat Gut Lipid Malabsorption and Atrophy

Reference #: 1718 The University of South Carolina is offering licensing opportunities for Nepenthes GDSL Lipase to Treat Gut Lipid Malabsorption and Atrophy. Background: The absorption of dietary lipids in the small intestine is a fundamental biological process central to maintaining energy balances in tissues. Atrophy occurs when the energetic...

Published: 12/17/2024 | Inventor(s): Jason Kubinak

Keywords(s):

Category(s): Health Sciences, Biomedical and Life Sciences

Acquisition – Software to Control Acquisition of Images for Near-Earth Object Survey Operations

The Acquisition subsystem in the Catalina Sky Survey (CSS) software suite manages the operation of telescopes and instruments to capture data on asteroids and Near-Earth Objects (NEOs). Once areas of the sky are selected for observation, Acquisition takes over, accepting the input from the Planner subsystem and coordinating the telescope, camera, and...