Search Results - jason+so

225 Results Sort By:
Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47
A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis. Problem: Phagocytosis of ‘self’ cells is generally inhibited by a key macrophage checkpoint interaction between SIRPα on the macrophage and...
Published: 12/15/2025   |   Inventor(s): Dennis Discher, Jason Andrechak, Lawrence Dooling
Keywords(s): Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics
THE APNEA ALARM: Biomarkers and a Device to Alarm when Risk of Death from Obstructive Apnea is Immediate
Analyzes electrocardiogram (ECG) data and sounds an alarm when two critical biomarkers exceed thresholds, enabling lifesaving intervention. Background: Epileptic seizures can cause laryngospasm sufficiently severe to produce complete airway obstruction. Once occluded, attempts to inhale against a closed airway get progressively stronger until attempts...
Published: 12/8/2025   |   Inventor(s): Mark Stewart, Richard Kollmar, Jason Lazar
Keywords(s): Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Healthcare IT, Technology Classifications > Medical Devices
Curative Locoregional Therapy Using Ablation or Catheter-Based Embolization of Targeted Hepatocellular Carcinoma by Delivering Supercharged NK Cells and CAR-NK or CAR-T Cells (UCLA Case No. 2023-115)
UCLA researchers in the School of Dentistry and Interventional Radiology have developed a groundbreaking curative treatment for hepatocellular carcinoma that combines locoregional therapy, such as ablation or catheter-based embolization, with targeted delivery of supercharged NK cells and CAR-NK or CAR-T cells, offering a highly effective approach that...
Published: 10/31/2025   |   Inventor(s): Anahid Jewett, Steven Raman, Jason Chiang
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
High-Throughput Cell Screening With Interferometric Cytometry (Case No. 2007-720)
Summary The combined technology platform encompasses optical cytometry via interferometric membrane probing and cell mechanical / membrane property characterization, using reflective microparticles and interferometric imaging to measure deformation and viscoelastic response of live cells. The approach links physical membrane dynamics to cellular state,...
Published: 9/25/2025   |   Inventor(s): Michael Teitell, James Gimzewski, Jason Reed
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems
Molecular Regulation of Stroke-Resistant Neurons (UCLA Case No. 2020-937)
Researchers in the Department of Neurology at UCLA have identified pharmacologic compounds capable of crossing the blood brain barrier that dramatically promote neurite outgrowth after stroke, thereby promoting recovery. Background: A stroke occurs when the blood supply of oxygen is interrupted to the brain, preventing brain tissue from receiving oxygen...
Published: 10/8/2025   |   Inventor(s): Jason Hinman
Keywords(s):  
Category(s): Therapeutics > CNS and Neurology
Scalable Van Der Waals Superlattices for Absorbers and Emitters (Case No. 2021-318)
Summary UCLA researchers have developed scalable Van der Waals superlattice materials designed as absorbers and emitters with tunable optical/electronic properties, enabling better control over thermal radiation or photonic emission across a range of wavelengths. Background Existing absorber and emitter materials for photonic and thermal applications...
Published: 10/1/2025   |   Inventor(s): Artur Davoyan, Deep Jariwala, Jason Lynch, Pawan Kumar, Francisco Barrera
Keywords(s):  
Category(s): Materials, Electrical, Electrical > Signal Processing, Materials > Semiconducting Materials
Novel MARK4 Inhibitors for Neurodegenerative Disorders (UCLA Case No. 2021-321)
UCLA researchers in the Department of Neurology have developed highly selective inhibitors of MARK4, aiming to revolutionize the treatment landscape for cancer and neurodegenerative disease through precise molecular targeting. BACKGROUND: MARK4 (Microtubule Affinity-Regulating Kinase 4) is a serine/threonine kinase from the AMP-activated protein...
Published: 9/10/2025   |   Inventor(s): Varghese John, Jason Hinman, Jesus Campagna
Keywords(s):  
Category(s): Therapeutics > CNS and Neurology
Dual-Function Green Solvents and Monomers for Utilizing Waste Plastics in 3D Printing
The Problem: The increasing generation of plastic waste, such as polystyrene (PS), polymethyl methacrylate (PMMA), and polyvinyl chloride (PVC), poses an environmental challenge. Traditional methods for managing plastic waste (e.g. landfilling and incineration), have drawbacks such as environmental pollution and limited resource recovery. Mechanical...
Published: 8/8/2025   |   Inventor(s): Jason Bara, Zahra Sekhavat Pour, Sourav Chatterjee
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Manufacturing, Technology Classifications > Materials
Ionizable and Cationic Lipids with Components Derived From Glycerol
The Problem: The field of nucleic acid therapeutics depends critically on effective delivery systems to protect and transport the therapeutic into the target cells. Ionizable lipids are the key components in the state-of-the-art delivery systems for RNA. However, current major limitations include poor biodegradability, low thermostability, limited...
Published: 8/4/2025   |   Inventor(s): Jason Bara, Talia Shmool
Keywords(s):  
Category(s): Technology Classifications > Healthcare, Technology Classifications > Manufacturing
OPG153-based vaccine for targeted mpox immunization
Background The global re-emergence of monkeypox virus (MPXV) has created a critical need for effective and well-tolerated vaccines to prevent infection, limit disease severity, and reduce transmission. As an orthopoxvirus related to smallpox, mpox presents a unique public health challenge, especially for immuno­compromised populations. Current...
Published: 11/25/2025   |   Inventor(s): Jason McLellan, Ling Zhou, Emily Rundlet, Emanuele Andreano, Rino Rappuoli, Ida Paciello, Giulia Realini, Federica Perrone
Keywords(s):  
Category(s): Life sciences > Therapeutics > Vaccines
1 2 3 4 5 6 7 8 9 10 ...