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Portable Perfusion Apparatus for Ex Vivo Tissue

A portable perfusion apparatus that cycles perfusate through ex vivo vertebrate tissues, enabling field deployment for preservation and training. Problem: Amputated extremities can lose viability before reattachment, especially in remote or traumatic settings. Existing perfusion machines may be too large for rapid deployment and are often limited to...

Published: 4/6/2026 | Updated: 4/6/2026 | Inventor(s): Edward Cantu, Rikesh Gandhi, Lawrence Levin, Jason Wink, Matthew Winterton

Keywords(s): Orthopedics, Surgery

Category(s): Technology Classifications > Medical Devices

Systems and Methods for Concurrent Biochemical Immunoassay and Cellular Traction Force Measurement in Hydrogels

This invention relates to a platform that couples bead-based immunoassays with 3D traction force microscopy (TFM) within a single hydrogel substrate to quantify time-resolved biochemical cues and cell-generated mechanical forces at matched locations. This invention allows researchers to directly test how local molecular cues influence cell mechanics...

Published: 3/23/2026 | Updated: 3/23/2026 | Inventor(s): Alex McGhee, Kelvin Pond, A Departmental Work

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics > Sensors and Detection, Technology Classifications > Engineering & Physical Sciences > Photonics, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays

Bubble‑Free Cell Culture System for Simulated Microgravity Research

CellPod is a disposable, bubble‑free cell culture container that makes simulated‑microgravity experiments reliable, repeatable, and far easier to run in everyday research labs. Advantages Prevents air bubble formation, improving experimental reliability and reproducibility Integrated accelerometer enables real-time validation of simulated microgravity...

Published: 4/24/2026 | Updated: 3/9/2026 | Inventor(s): Begum Mathyk, Stephanie Carey, Matthew Anderson, John Templeton, Jason Caouette

Keywords(s): 3D Printing, Laboratory Devices, Space and Exploration

Category(s): Technology Classifications > Engineering > Additive Manufacturing, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Medical Devices, Technology Classifications > Engineering > Mechanical Engineering, Technology Classifications > Electronics > Electronics Sensors

APMBR (Anaerobic-Phototrophic Membrane Bioreactor)

Advantages High carbon removal efficiency (up to ~95% TOC and ~98% COD under nominal operation) Integrated biological and membrane filtration system with automated controls Produces nutrient-rich permeate suitable for hydroponic plant growth Compact, small-footprint design with low consumable requirements Demonstrated stable operation with resilience...

Published: 3/2/2026 | Updated: 3/2/2026 | Inventor(s): Daniel Yeh, Luke Roberson, Daniella Saetta, Jason Fischer, Lawrence Koss

Keywords(s): Water / Waste Treatment

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Energy & Environment > Energy Engineering, Technology Classifications > Energy & Environment

Fermentation Membrane Bioreactor for Biomanufacturing

Advantages Enables continuous, high-yield biomanufacturing beyond batch limitations Delivers real-time product extraction without interrupting fermentation Lowers operating costs by using waste-derived and alternative feedstocks Scales easily with automated control, ensuring consistent product quality Summary Traditional fermentation systems...

Published: 4/22/2026 | Updated: 2/19/2026 | Inventor(s): Daniel Yeh, Luke Roberson, Jason Fischer, Daniella Saetta, Alexandra Smith

Keywords(s): Biotechnology, Chemistry and Chemical Engineering, Energy Engineering, Renewable Energy

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Engineering > Chemical Engineering, Technology Classifications > Engineering > Manufacturing, Technology Classifications > Energy & Environment

Dark Eye Harvester

This invention involves using an insulated light-proof chamber that allows the harvesting of eyes or another light-sensitive biomaterial without light exposure, allowing visual rhodopsin to regenerate more efficiently. The chamber has a cylindrical shape and is attached to a chest cooler with handles on top to rotate the walls. The chamber has multiple...

Published: 2/9/2026 | Updated: 2/9/2026 | Inventor(s): A Departmental Work, Michael Brown

Keywords(s):

Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Research Tools

Engineered prefusion-stabilized RSV fusion proteins and nucleic acids for enhanced vaccines and diagnostics

This technology uses engineered RSV prefusion proteins with specific mutations to boost stability, expression, and shelf life, enabling more effective and affordable RSV vaccines, treatments, and diagnostics in both protein and nucleic acid (e.g., mRNA) formats. Background Respiratory Syncytial Virus (RSV) is a leading cause of severe respiratory...

Published: 1/27/2026 | Updated: 1/27/2026 | Inventor(s): Jason McLellan, Ajit Ramamohan, Jimmy Gollihar, Raghav Shroff, Thomas Segall-Shapiro, Shaunak Kar, Daniel Boutz, Andrew Horton, Nasim Abdi, Daniel Diaz

Keywords(s):

Category(s): Life sciences > Therapeutics > Vaccines

Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47

A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis. Problem: Phagocytosis of ‘self’ cells is generally inhibited by a key macrophage checkpoint interaction between SIRPα on the macrophage and...

Published: 12/15/2025 | Updated: 12/15/2025 | Inventor(s): Dennis Discher, Jason Andrechak, Lawrence Dooling

Keywords(s): Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology

Category(s): Technology Classifications > Therapeutics

THE APNEA ALARM: Biomarkers and a Device to Alarm when Risk of Death from Obstructive Apnea is Immediate

Analyzes electrocardiogram (ECG) data and sounds an alarm when two critical biomarkers exceed thresholds, enabling lifesaving intervention. Background: Epileptic seizures can cause laryngospasm sufficiently severe to produce complete airway obstruction. Once occluded, attempts to inhale against a closed airway get progressively stronger until attempts...

Published: 1/30/2026 | Updated: 12/8/2025 | Inventor(s): Mark Stewart, Richard Kollmar, Jason Lazar

Keywords(s): Technologies

Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Healthcare IT, Technology Classifications > Medical Devices

Curative Locoregional Therapy Using Ablation or Catheter-Based Embolization of Targeted Hepatocellular Carcinoma by Delivering Supercharged NK Cells and CAR-NK or CAR-T Cells (UCLA Case No. 2023-115)

UCLA researchers in the School of Dentistry and Interventional Radiology have developed a groundbreaking curative treatment for hepatocellular carcinoma that combines locoregional therapy, such as ablation or catheter-based embolization, with targeted delivery of supercharged NK cells and CAR-NK or CAR-T cells, offering a highly effective approach that...

Published: 10/31/2025 | Updated: 10/23/2025 | Inventor(s): Anahid Jewett, Steven Raman, Jason Chiang

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

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