Search Results - leslie+gunatilaka

12 Results Sort By:
Analogues of Withanolide E Sensitize Cancer Cells Toward Apoptosis
Abstract: The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) protein has been a target of interest in cancer therapy because it plays a large role in inducing cell apoptosis in cancer cells but not in normal cells.  Although TRAIL has been reported to successfully target certain tumor cells which are resistant to traditional chemotherapy...
Published: 12/4/2024   |   Inventor(s): Thomas Sayers, Alan Brooks, Curtis Henrich, Poonam Tewary, James McMahon, Leslie Gunatilaka, Yaming Xu, Kithsiri Wijeratne
Keywords(s): APOPTOSIS, Immunotherapy, TLR3 ligands, TRAIL, withanolide
Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration
An Efficient And Improved Chemical Conversion Of The Natural Product Physachenolide D (LG-01) To Its Analogue LG-134 With Potent Anticancer Activity
Invention: An improved process of chemical conversion of the natural plant product physachenolide D (PCD) to a C-18 analogue (LG-134) of physachenolide C (PCC).Background: The standard yield of LG-134 using current methods is relatively low at 1/3 resultant from original products. This method allows for the yield to be double current chemical processes....
Published: 4/3/2023   |   Inventor(s): Leslie Gunatilaka, Kithsiri Wijeratne, Yaming Xu
Keywords(s):  
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences > Therapeutics
Amphiphilic macromolecules with novel hydrophobic segments
­ ​ ​ Invention Summary: Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads...
Published: 12/4/2024   |   Inventor(s): Kathryn Uhrich, Allison Faig, Dalia Abdelhamid, Li Gu
Keywords(s): Antibacterial, Biomaterials, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Specific 17-Beta-Hydroxywithanolides Sensitize Cancer Cells to Apoptosis in Response to Toll-like Receptor (TLR)
This invention describes the use of physachenolide C for cancer treatment through cancer cell apoptosis (cell self-destruction) through extrinsic pathways of “death ligand” proteins. Physachenolide C is a natural product in which the 17-beta-hydroxy group and orientation of the molecule chain result in improved apoptosis sensitivity, with...
Published: 6/6/2024   |   Inventor(s): Leslie Gunatilaka, Yaming Xu, Kithsiri Wijeratne, Thomas Sayers, Poonam Tewary, Alan Brooks, Curtis Henrich, James McMahon
Keywords(s):  
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Healthcare Portfolios > Oncology
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 2/18/2025   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Semi-Synthetic 17beta-Hydroxywithanolides (17-Bhws) Promote Caspase-8-Dependent Apoptosis in Renal Carcinoma and Melanoma and Specifically Inhibit Human Prostate Cancer Cell Proliferation
This novel, partially naturally-derived compound can be used to treat three different kinds of cancer (melanoma, renal carcinoma, and prostate cancer) in patients without other treatment options. Background: The treatment of all kinds of cancers leaves much to be desired in terms of an efficient treatment that is highly effective and has comparably...
Published: 7/16/2024   |   Inventor(s): Leslie Gunatilaka, Kithsiri Wijeratne, Yaming Xu, Thomas Sayers, Poonam Tewary, Alan Brooks
Keywords(s):  
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
A Water-Soluble Prodrug for the Heat Shock-Inducing Compound Withaferin A
University of Arizona researchers have developed an economically viable and environmentally friendly method for producing and isolating large quantities of both Withaferin A and the novel withanolides. Aeroponic cultivation is a significant achievement as acquiring an abundant supply of starting material is often a significant hurdle in the development...
Published: 4/3/2023   |   Inventor(s): Leslie Gunatilaka, Dennis Ray, Yaming Xu, Kithsiri Wijeratne
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
Twistron Mechanical Energy Harvesters
Mechanical energy harvesters are needed for diverse applications, including self-powered wireless sensors, structural and human health monitoring systems, automotive technologies, and the extraction of energy from ocean waves. Until now, few harvesters have been flexible enough to be used as yarns in textiles, and the performance of such yarns has been...
Published: 6/26/2024   |   Inventor(s): Shi Hyeong Kim, Carter Haines, Na Li, Keon Jung Kim, Tae Jin Mun, Changsoon Choi, Jiangtao Di, Shaoli Fang, Seon Jeong Kim, Ray Baughman
Keywords(s): Automotive, Carbon Nanomaterials, Carbon Nanotubes, Electronics, Energy, Cleantech & Environmental, Engineering & Physical Sciences, Renewable Energy, Sensors & Controls, Textiles, Wireless
Category(s): Nanotechnology
Intelligent Textiles Prepared from Nanofiber Yarns and Polymer Fiber Actuators
While there has always been a desire for smart textiles, including fabrics which adapt depending on environmental stimuli, it has yet to be effectively accomplished due to the lack of suitable materials. These polymer fiber actuators have enabled the creation of fabrics that can reversibly change properties such as porosity, shape, color and texture....
Published: 4/22/2021   |   Inventor(s): Ray Baughman, Ozer Goktepe, Fatma Goktepe, Na Li, Marcio Lima, Carter Haines, Shaoli Fang
Keywords(s): Engineering & Physical Sciences, Industrial & Manufacturing, Nanotechnology, Polymers, Textiles
Category(s): Materials
Natural Product Modulators of Stress Response
In response to many stresses, including heat, oxidizing conditions, and exposure to toxic compounds, plant cells up-regulate an evolutionarily conserved set of helper molecules known as heat shock proteins (Hsp). Increased expression of these proteins protects the organism against stress-induced damage. The investigators have isolated a secondary...
Published: 4/3/2023   |   Inventor(s): Leslie Gunatilaka, Luke Whitesell, Kithsiri Wijeratne, Thomas Turbyville
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
1 2