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Search Results - yaming+xu
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Analogues of Withanolide E Sensitize Cancer Cells Toward Apoptosis
Abstract: The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) protein has been a target of interest in cancer therapy because it plays a large role in inducing cell apoptosis in cancer cells but not in normal cells. Although TRAIL has been reported to successfully target certain tumor cells which are resistant to traditional chemotherapy...
Published: 5/22/2024
|
Inventor(s):
Thomas Sayers
,
Alan Brooks
,
Curtis Henrich
,
Poonam Tewary
,
James McMahon
,
Leslie Gunatilaka
,
Yaming Xu
,
Kithsiri Wijeratne
Keywords(s):
APOPTOSIS
,
Immunotherapy
,
TLR3 ligands
,
TRAIL
,
withanolide
Category(s):
TherapeuticArea > Oncology
,
Application > Therapeutics
,
Collaboration Sought > Licensing
,
Collaboration Sought > Collaboration
An Efficient And Improved Chemical Conversion Of The Natural Product Physachenolide D (LG-01) To Its Analogue LG-134 With Potent Anticancer Activity
Invention: An improved process of chemical conversion of the natural plant product physachenolide D (PCD) to a C-18 analogue (LG-134) of physachenolide C (PCC).Background: The standard yield of LG-134 using current methods is relatively low at 1/3 resultant from original products. This method allows for the yield to be double current chemical processes....
Published: 4/3/2023
|
Inventor(s):
Leslie Gunatilaka
,
Kithsiri Wijeratne
,
Yaming Xu
Keywords(s):
Category(s):
Technology Classifications > Agriculture & Horticulture
,
Technology Classifications > Life Sciences > Therapeutics
Methods for Modeling Water Quality
The Problem: Monitoring and mapping inland water quality is critical for sustainability of water supplies for human consumption, agriculture, industry, and other economic activities. In previous studies, empirical models have been widely used to map water quality parameters for inland waters using remotely sensed imagery. Due to the complex...
Published: 6/2/2023
|
Inventor(s):
Hongxing Liu
,
Min Xu
,
Richard Beck
Keywords(s):
Category(s):
Technology Classifications > Communication
,
Technology Classifications > Systems & Services
Specific 17-Beta-Hydroxywithanolides Sensitize Cancer Cells to Apoptosis in Response to Toll-like Receptor (TLR)
This invention describes the use of physachenolide C for cancer treatment through cancer cell apoptosis (cell self-destruction) through extrinsic pathways of “death ligand” proteins. Physachenolide C is a natural product in which the 17-beta-hydroxy group and orientation of the molecule chain result in improved apoptosis sensitivity, with...
Published: 6/6/2024
|
Inventor(s):
Leslie Gunatilaka
,
Yaming Xu
,
Kithsiri Wijeratne
,
Thomas Sayers
,
Poonam Tewary
,
Alan Brooks
,
Curtis Henrich
,
James McMahon
Keywords(s):
Category(s):
Technology Classifications > Agriculture & Horticulture
,
Technology Classifications > Healthcare Portfolios > Oncology
Semi-Synthetic 17beta-Hydroxywithanolides (17-Bhws) Promote Caspase-8-Dependent Apoptosis in Renal Carcinoma and Melanoma and Specifically Inhibit Human Prostate Cancer Cell Proliferation
This novel, partially naturally-derived compound can be used to treat three different kinds of cancer (melanoma, renal carcinoma, and prostate cancer) in patients without other treatment options. Background: The treatment of all kinds of cancers leaves much to be desired in terms of an efficient treatment that is highly effective and has comparably...
Published: 7/16/2024
|
Inventor(s):
Leslie Gunatilaka
,
Kithsiri Wijeratne
,
Yaming Xu
,
Thomas Sayers
,
Poonam Tewary
,
Alan Brooks
Keywords(s):
Category(s):
Technology Classifications > Agriculture & Horticulture
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Oncology
A Water-Soluble Prodrug for the Heat Shock-Inducing Compound Withaferin A
University of Arizona researchers have developed an economically viable and environmentally friendly method for producing and isolating large quantities of both Withaferin A and the novel withanolides. Aeroponic cultivation is a significant achievement as acquiring an abundant supply of starting material is often a significant hurdle in the development...
Published: 4/3/2023
|
Inventor(s):
Leslie Gunatilaka
,
Dennis Ray
,
Yaming Xu
,
Kithsiri Wijeratne
Keywords(s):
Category(s):
Technology Classifications > Life Sciences
,
Technology Classifications > Life Sciences > Therapeutics