Search Results - withanolide

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Analogues of Withanolide E Sensitize Cancer Cells Toward Apoptosis
Abstract: The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) protein has been a target of interest in cancer therapy because it plays a large role in inducing cell apoptosis in cancer cells but not in normal cells.  Although TRAIL has been reported to successfully target certain tumor cells which are resistant to traditional chemotherapy...
Published: 12/4/2024   |   Inventor(s): Thomas Sayers, Alan Brooks, Curtis Henrich, Poonam Tewary, James McMahon, Leslie Gunatilaka, Yaming Xu, Kithsiri Wijeratne
Keywords(s): APOPTOSIS, Immunotherapy, TLR3 ligands, TRAIL, withanolide
Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration
Use of Cucurbitacins and Withanolides for the Treatment of Cancer
Abstract: Certain members of the cucurbitacin and Withanolide family have been identified that can sensitize some tumor cell lines to cell death (apoptosis) on subsequent exposure of the cells to pro-apoptotic receptor agonists (PARAS) of the TRAIL "death receptors". These PARAS include TRAIL itself, and agonist antibodies to two of its receptors death...
Published: 5/22/2024   |   Inventor(s): Thomas Sayers, Kirk Gustafson, Karen Erickson, Alan Brooks, Curtis Henrich, Nancy Booth
Keywords(s): cucurbitacin, Immunotherapy, mapatumamab, TRAIL, withanolide
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing