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Search Results - alan+brooks
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Analogues of Withanolide E Sensitize Cancer Cells Toward Apoptosis
Abstract: The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) protein has been a target of interest in cancer therapy because it plays a large role in inducing cell apoptosis in cancer cells but not in normal cells. Although TRAIL has been reported to successfully target certain tumor cells which are resistant to traditional chemotherapy...
Published: 5/22/2024
|
Inventor(s):
Thomas Sayers
,
Alan Brooks
,
Curtis Henrich
,
Poonam Tewary
,
James McMahon
,
Leslie Gunatilaka
,
Yaming Xu
,
Kithsiri Wijeratne
Keywords(s):
APOPTOSIS
,
Immunotherapy
,
TLR3 ligands
,
TRAIL
,
withanolide
Category(s):
TherapeuticArea > Oncology
,
Application > Therapeutics
,
Collaboration Sought > Licensing
,
Collaboration Sought > Collaboration
Use of Cucurbitacins and Withanolides for the Treatment of Cancer
Abstract: Certain members of the cucurbitacin and Withanolide family have been identified that can sensitize some tumor cell lines to cell death (apoptosis) on subsequent exposure of the cells to pro-apoptotic receptor agonists (PARAS) of the TRAIL "death receptors". These PARAS include TRAIL itself, and agonist antibodies to two of its receptors death...
Published: 5/22/2024
|
Inventor(s):
Thomas Sayers
,
Kirk Gustafson
,
Karen Erickson
,
Alan Brooks
,
Curtis Henrich
,
Nancy Booth
Keywords(s):
cucurbitacin
,
Immunotherapy
,
mapatumamab
,
TRAIL
,
withanolide
Category(s):
Application > Therapeutics
,
TherapeuticArea > Oncology
,
Collaboration Sought > Licensing
Specific 17-Beta-Hydroxywithanolides Sensitize Cancer Cells to Apoptosis in Response to Toll-like Receptor (TLR)
This invention describes the use of physachenolide C for cancer treatment through cancer cell apoptosis (cell self-destruction) through extrinsic pathways of “death ligand” proteins. Physachenolide C is a natural product in which the 17-beta-hydroxy group and orientation of the molecule chain result in improved apoptosis sensitivity, with...
Published: 6/6/2024
|
Inventor(s):
Leslie Gunatilaka
,
Yaming Xu
,
Kithsiri Wijeratne
,
Thomas Sayers
,
Poonam Tewary
,
Alan Brooks
,
Curtis Henrich
,
James McMahon
Keywords(s):
Category(s):
Technology Classifications > Agriculture & Horticulture
,
Technology Classifications > Healthcare Portfolios > Oncology
Semi-Synthetic 17beta-Hydroxywithanolides (17-Bhws) Promote Caspase-8-Dependent Apoptosis in Renal Carcinoma and Melanoma and Specifically Inhibit Human Prostate Cancer Cell Proliferation
This novel, partially naturally-derived compound can be used to treat three different kinds of cancer (melanoma, renal carcinoma, and prostate cancer) in patients without other treatment options. Background: The treatment of all kinds of cancers leaves much to be desired in terms of an efficient treatment that is highly effective and has comparably...
Published: 7/16/2024
|
Inventor(s):
Leslie Gunatilaka
,
Kithsiri Wijeratne
,
Yaming Xu
,
Thomas Sayers
,
Poonam Tewary
,
Alan Brooks
Keywords(s):
Category(s):
Technology Classifications > Agriculture & Horticulture
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Oncology