Search Results - paul+love

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Enhanced Antigen Reactivity of Immune Cells Expressing a Mutant Non-Signaling CD3 Zeta Chain
Abstract: Immunotherapy is a cutting-edge new category of treatment that aims to harness and, in some cases, modify the patient’s own immune cells to improve their ability to cure diseases. It can be an effective approach for a variety of conditions, ranging from cancer to inflammatory diseases.  However, a number of obstacles to the overall success...
Published: 4/8/2024   |   Inventor(s): Paul Love, Guillaume Gaud, Christian Hinrichs, John Davies
Keywords(s): CD3, Davies, Eunice Kennedy Shriver National Institute of Child Health an, Gaud, Hinrichs, Immuno-receptor Tyrosine-based Activation Motif, Immunotherapy, ITAM, Love, National Cancer Institute, Nci, NICHD, T Cell Receptor, TCR, Zeta Chain
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology
T cell tuning molecules that modify the immune response to cancer cells
Abstract: Researchers at NIH/NICHD have identified approximately 200 proteins as candidate molecules (leads) that “fine tune” T cell receptor (TCR) signaling. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks partners to collaborate on in vitro studies to validate these potential immunomodulators and to conduct...
Published: 4/8/2024   |   Inventor(s): Paul Love, Zhenju Li, Julia Pinkhasov
Keywords(s):  
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics
CCR9 Knockout Mice
Ccr9-/- mice may be useful for studying the role of CCR9 in T lymphocyte development and migration. Mice will be distributed by The Jackson Laboratory; details about this mouse strain (Stock No. 027041) may be found at https://www.jax.org/strain/027041.
Published: 10/28/2024   |   Inventor(s): Paul Love, Shoji Uehara, Joshua Farber
Keywords(s): CCR9, Distribution, Jackson, Knockout, Laboratories, Mice, RM, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials