Search Results - sefika+banu+ozkan

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Computational Method to Identify Protein Hotspots and Allosteric Sites
Invention Description Protein allostery is important in many biological processes and drug development. Understanding the mechanisms involved would be highly beneficial for therapeutic interventions. Existing techniques focus primarily on equilibrium dynamics and network analysis for allosteric interaction mapping. Unfortunately, these are limited...
Published: 1/12/2026   |   Inventor(s): Paul Campitelli, Tushar Modi, Sefika Banu Ozkan
Keywords(s):  
Category(s): Vaccines/Antimicrobials, Proteomic Assays/Reagents/Tools, Life Science (All LS Techs), Computing & Information Technology, Artificial Intelligence/Machine Learning
Computational Method to Identify Mutational Epistasis in Proteins
Invention Description Viral evolution, particularly rapid viral evolution, can lead to the emergence of variants of concern. In order to develop effective antiviral strategies, it is essential to understand the molecular mechanisms driving these adaptations. Some research has focused on identifying adaptive mutations and how they impact protein structure...
Published: 1/12/2026   |   Inventor(s): Paul Campitelli, Nicholas Ose, Tushar Modi, Ismail Can Kazan, Sefika Banu Ozkan
Keywords(s):  
Category(s): Vaccines/Antimicrobials, Life Science (All LS Techs), Computing & Information Technology, Artificial Intelligence/Machine Learning, COVID-19, SARS-CoV-2, Coronavirus
Dynamic-based Computational Drug Design Strategy for WW Domains
Understanding the relationship between protein sequence-structure and binding dynamics is not well understood. Of particular interest is the ability to relate foldability and function of a protein and the ability to characterize how foldability and binding change based on mutations in the protein sequence. WW domains are one of the most abundant independently...
Published: 6/3/2025   |   Inventor(s): Jin Lu, Ismail Can Kazan, Sefika Banu Ozkan
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools