Search Results - fuming+zhang

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Nasal spray using PPS and MPS for COVID-19 prevention and treatment
RPI ID: 2021-049-201 Innovation Summary: A nasal spray formulation combines pentosan polysulfate and mucopolysaccharide polysulfate to prevent and treat COVID-19. The compounds act as viral entry inhibitors by blocking spike protein binding to host cells. The spray is designed for prophylactic and therapeutic use, with potential for broad-spectrum...
Published: 3/10/2026   |   Inventor(s): Fuming Zhang, Jawed Fareed, Walter Jeske, Robert Linhardt
Keywords(s): antiviral drug, COVID19, Heparin, mucopolysachharide polysulfate, Nasal spray, Pentosan polysulfate, prevention
Category(s): Biotechnology and the Life Sciences
Heparin and Heparin Analogs with Exceptional Binding Affinity to SARS-CoV-2 Spike Protein as Potential Therapeutics
RPI ID: 2020-082-401 / 2020-082-601 / 2020-082-602 Innovation Summary: Compositions containing sulfated polysaccharides such as pentosan polysulfate and mucopolysaccharide polysulfate are designed to inhibit SARS-CoV-2 by blocking viral entry and replication. These formulations are intended for mucosal delivery via nasal spray or aerosol, enabling...
Published: 3/10/2026   |   Inventor(s): So Young Kim, Weihua Jin, Jonathan Dordick, Fuming Zhang, Seok-Joon Kwon, Paul Kwon, Keith Fraser, Robert Linhardt
Keywords(s): Heparin, Non-Anticoagulant Heparin, SARS-CoV-2 Spike Protein, TriS HS
Category(s): Biotechnology and the Life Sciences
MPS and PPS and other sulfated GAG analogs to treat/prevent Monkeypox
RPI ID: 2023-007-601 Innovation Summary: This technology describes therapeutic systems and methods using sulfated glycosaminoglycans (GAGs) and GAG analogs to treat or prevent monkeypox virus (Mpox) infections. The compounds interfere with viral attachment and entry mechanisms, reducing infectivity. The approach is designed for topical or systemic...
Published: 3/10/2026   |   Inventor(s): Robert Linhardt, Jonathan Dordick, Deling Shi, Fuming Zhang
Keywords(s): A29, Chondroitin sulfate, Dermatan sulfate, Heparin, Monkeypox virus
Category(s): Biotechnology and the Life Sciences
Non-contact railway inspection
VALUE PROPOSITION Rail transportation is periodically marred by accidents, highlighting ongoing safety challenges. There is a need for effective rail inspection methods. Current techniques are hindered by limitations such as low detection accuracy and sensitivity, particularly at high speeds. This technology introduces a novel method for high-speed,...
Published: 9/27/2024   |   Inventor(s): Yiming Deng, Sunil Chakrapani, Ming Han, Zebadiah Miles
Keywords(s):  
Category(s): Analytical Instruments, Test and Measurement, Transportation
Whole Tissue Protein Mapping
A tool and method for precise, high-throughput spatial mapping of proteins across whole tissue samples. Background: Spatial proteomics enables delineation of spatial localization of proteins within cells and tissues. This ability to identify and study the relative location and quantification of one or more proteins, whether ones that are endogenously...
Published: 2/19/2026   |   Inventor(s): Jun Qu, Ming Zhang, Min Ma
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Bioinformatics
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023   |   Inventor(s): Leilei Peng, Yu Li, Han Zhang
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
Helical Sulfono-γ-AApeptide Antagonize β-Catenin Signaling
Advantages Disrupts protein-protein interactions Mimics the α-helical domain More potent cellular activity Potential anti-cancer therapeutics Exhibits excellent folding stability with defined helices Demonstrates remarkable enzymatic stability for 24 hours Summary Researchers have developed sulfono-γ-AApeptides that are able...
Published: 11/19/2025   |   Inventor(s): Jianfeng Cai, Peng Sang, Yan Shi, Haitao Ji, Min Zhang
Keywords(s): Cancer, Cancer Treatment Leukemias, Cancer Treatment Lymphomas, Peptides, Therapeutics
Category(s): Technology Classifications > Cancer
Automated Glomerular Segmentation Pipeline for 3D MRI
Recent studies conclude that a strong correlation exists between the numbers of glomerular in the kidney and renal diseases. These findings generate great interest in accurately counting glomeruli. Traditionally, the glomerulus is counted using histological sections, which have several limitations. First, histology based counting relies on techniques...
Published: 2/26/2026   |   Inventor(s): Teresa Wu, Min Zhang
Keywords(s): Algorithm Development, Imaging, Materials and Electronics, Mechanical and Manufacturing, Medical Devices and Imaging, Modeling, Nephrology, Networks, IT, Software and Communication
Category(s): Computing & Information Technology
Fiber-Optic Interferometric Sensors
Executive SummaryFiber-optic sensors using optical interferometers have application for sensing a variety of parameters such as acoustic waves, strain, temperature, and refractive index. The technology is a demodulation method that does not require laser wavelength tuning. The technology provides adaptive ultrasound detection with improved accuracy...
Published: 8/18/2025   |   Inventor(s): Ming Han
Keywords(s):  
Category(s): Analytical Instruments, Devices, Test and Measurement
Nest DNN, a Pruning-and-Recovery Paradigm for Deep Neural Networks
Executive Summary Neural networks are employed ubiquitously in our lives today. Found in applications such as video games, face identification, autonomous vehicles navigation, and medical diagnostic tools, these algorithms require a hefty amount of computer resources. In instances where resource demand is greater than availability, accuracy and...
Published: 9/15/2025   |   Inventor(s): Mi Zhang, Biyi Fang, Xiao Zeng
Keywords(s):  
Category(s): Computer Software, Data Processing/Analysis, Informatics
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