Search Results - robert+linhardt

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Confined oil in beaded polymeric fibers with advanced thermoregulating properties
RPI ID: 2019-033-201, 2019-033-601 Innovation Summary: A coaxial wet-wet electrospinning process enables the creation of core-shell microfibers, where the core contains a phase-change material (PCM) like coconut oil and the shell is composed of cellulose. The fibers are extruded into an ethanol-water coagulation bath, forming a beaded morphology with...
Published: 3/10/2026   |   Inventor(s): Ranodhi Udangawa, Charles Willard, Chiara Mancinelli, Caitlyn Chapman, Robert Linhardt, Trevor Simmons
Keywords(s): cellulose, Coconut oil, Core–shell microfiber composites, Electrospinning, Phase changing materials
Category(s): Energy, Environment and Smart Systems
Novel nanocomposite fibers with a dramatic reduction in human plasma coagulation time
RPI ID: 2019-034-401 Innovation Summary: This invention describes a method for producing cellulose-nanoclay hemostatic nanocomposite fibers. The process involves dissolving cellulose in a room-temperature ionic liquid and integrating nanoclay particles to form a homogenous solution. The resulting fibers exhibit dramatically reduced human plasma coagulation...
Published: 3/10/2026   |   Inventor(s): Ranodhi Udangawa, Chiara Mancinelli, Caitlyn Chapman, Charles Willard, Trevor Simmons, Robert Linhardt
Keywords(s): cellulose, Electrospinning, Halloysite clay, Hemostatic, Kaolin clay
Category(s): Nanotechnology and Advanced Materials
Nasal spray using PPS and MPS for COVID-19 prevention and treatment
RPI ID: 2021-049-201 Innovation Summary: A nasal spray formulation combines pentosan polysulfate and mucopolysaccharide polysulfate to prevent and treat COVID-19. The compounds act as viral entry inhibitors by blocking spike protein binding to host cells. The spray is designed for prophylactic and therapeutic use, with potential for broad-spectrum...
Published: 3/10/2026   |   Inventor(s): Fuming Zhang, Jawed Fareed, Walter Jeske, Robert Linhardt
Keywords(s): antiviral drug, COVID19, Heparin, mucopolysachharide polysulfate, Nasal spray, Pentosan polysulfate, prevention
Category(s): Biotechnology and the Life Sciences
Heparin and Heparin Analogs with Exceptional Binding Affinity to SARS-CoV-2 Spike Protein as Potential Therapeutics
RPI ID: 2020-082-401 / 2020-082-601 / 2020-082-602 Innovation Summary: Compositions containing sulfated polysaccharides such as pentosan polysulfate and mucopolysaccharide polysulfate are designed to inhibit SARS-CoV-2 by blocking viral entry and replication. These formulations are intended for mucosal delivery via nasal spray or aerosol, enabling...
Published: 3/10/2026   |   Inventor(s): So Young Kim, Weihua Jin, Jonathan Dordick, Fuming Zhang, Seok-Joon Kwon, Paul Kwon, Keith Fraser, Robert Linhardt
Keywords(s): Heparin, Non-Anticoagulant Heparin, SARS-CoV-2 Spike Protein, TriS HS
Category(s): Biotechnology and the Life Sciences
Microbial Synthesis of Sulfated Glycosaminoglycans
RPI ID: 2020-014-401 Innovation Summary: Recombinant microorganisms are engineered to biosynthesize sulfated glycosaminoglycans (GAGs) directly in vivo, bypassing the need for animal-derived sources. The system incorporates genetic pathways for polymerization and sulfation, enabling controlled production of biologically active GAGs. This approach supports...
Published: 3/10/2026   |   Inventor(s): Abinaya Badri, Mattheos Koffas, Robert Linhardt, Asher Williams
Keywords(s): Animal-free Glycosaminoglycans, Metabolic engineering of E. coli, One pot microbial production of sulfated biologics
Category(s): Biotechnology and the Life Sciences
MPS and PPS and other sulfated GAG analogs to treat/prevent Monkeypox
RPI ID: 2023-007-601 Innovation Summary: This technology describes therapeutic systems and methods using sulfated glycosaminoglycans (GAGs) and GAG analogs to treat or prevent monkeypox virus (Mpox) infections. The compounds interfere with viral attachment and entry mechanisms, reducing infectivity. The approach is designed for topical or systemic...
Published: 3/10/2026   |   Inventor(s): Robert Linhardt, Jonathan Dordick, Deling Shi, Fuming Zhang
Keywords(s): A29, Chondroitin sulfate, Dermatan sulfate, Heparin, Monkeypox virus
Category(s): Biotechnology and the Life Sciences
Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
Ultrafast Thin-Film Vapor Deposition Technique
Invention Description The demand for advanced thin-film deposition techniques has grown substantially in recent years, driven by the development of next-generation electronic, optoelectronic, and energy devices. Traditional deposition methods, such as chemical vapor deposition, molecular beam epitaxy, and physical vapor deposition, have well-established...
Published: 2/26/2026   |   Inventor(s): Feng Yan, Lin Li
Keywords(s):  
Category(s): Semiconductors, Materials & Processes, Microelectronics, Physical Science, Semiconductor Devices, Manufacturing/Construction/Mechanical
Non-Invasive Plasma Discharge Tube Device for Treating Brain Tumors
Treating brain tumors, like glioblastoma, is challenging. Current glioblastoma drugs, Rapamycin and Temozolomide (TMZ), generally only extend life for a matter of months, are not very effective in treating recurring tumors, and have significant clinical toxicity. A novel Plasma Discharge Tube (PDT) device has the potential to be more effective and less...
Published: 1/9/2026   |   Inventor(s): Michael Keidar, Li Lin, Vikas Soni, Xiaoliang Yao, Dayun Yan, Jonathan Sherman
Keywords(s):  
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Surgical
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 1/9/2026   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
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