Search Results - duane+mitchell

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Metabolic Enhancement of T Cells for Effective Immunotherapy in Tumor Microenvironments
Enhancing Metabolic Fitness of T -Cells to Treat Central Nervous System Tumors This T cell-based immunotherapy aims to enhance anti-tumor immune response by addressing metabolic restrictions within tumor microenvironments. T cells play a crucial role in targeting immune responses and adaptive immunity. However, their ability to respond to cancer cells...
Published: 12/23/2024   |   Inventor(s): Loic Deleyrolle, Duane Mitchell, Jianping Huang, Linchun Jin
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Nanoparticle RNA Vaccine to Treat Gliomas
Encodes for Specific Antigens to Promote Anti-Tumor Immunity This cancer vaccine activates antigen-presenting cells and induces anti-tumor immune system activity for the treatment of diffuse intrinsic pontine gliomas (DIPG). DIPG tumors originate in the pons, an area of the brainstem controlling vital body functions such as breathing and heart rate....
Published: 7/30/2021   |   Inventor(s): Elias Sayour, James McGuiness, Hector Mendez-Gomez, Duane Mitchell
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Cellular Micro-Masonry System to Build Highly Defined 3D Biological Structures
Creates Precise Multicellular 3D Structures Needed for Experiments in Diverse Research Areas This micro-biofabrication system combines computer vision, robotics, micromanipulation tools, and a novel culture medium to enable the creation of optimized 3D cellular structures. A level of exquisite detail exists in the intricate pattern and spatial structure...
Published: 6/27/2021   |   Inventor(s): Thomas Angelini, Scott Banks, Sarah Ellison, Catherine Flores, Duane Mitchell, Cameron Morley
Keywords(s):  
Category(s): Technology Classifications > Engineering > Mechanical, Technology Classifications > Human Health Care > Diagnostics
Nanoparticle RNA Vaccine That Targets Slow-Cycling, Treatment-Resistant Cancer
Activates T-Cell Recognition of Tumor-Initiating Stem Cells in Mouse Model of Glioma This nanoparticle vaccine targets the slow-cycling, treatment-resistant, cancer stem cells to improve efficiency of anti-cancer drugs, thereby improving disease prognosis. Despite major developments in the field of anti-cancer therapies, tumor recurrence and metastasis...
Published: 2/13/2024   |   Inventor(s): Elias Sayour, Loic Deleyrolle, Hector Mendez-Gomez, Sadeem Qdaisat, Duane Mitchell
Keywords(s): Cancer, cancer stem cells, Immunotherapy, Nanoparticles, Vaccine development
Category(s): Technology Classifications > Human Health Care > Therapeutics
Loaded Dendritic Cells that Enhance Cellular Immunotherapy for Cancer
Increase Migration and Immune Response with Sarcosine-Loaded Dendritic CellsThese sarcosine-loaded dendritic cells exhibit enhanced migration to local lymph nodes, increasing the stimulation and migration of T-cells for cancer treatment. Immunotherapy has become a popular approach to treat cancer in recent years. A particular approach is providing patients...
Published: 6/27/2021   |   Inventor(s): Maryam Rahman, Hassan Azari, Duane Mitchell, Rolando Lovaton
Keywords(s): adoptive cellular therapy, cellular trafficking, chimeric antigen receptor, dendritic cell, Immunotherapy, Immunotherapy of Cancer, Migration, n-methyl-glycine, sarcosine
Category(s): Technology Classifications > Human Health Care > Therapeutics
Immune-Mediated Therapeutic Vaccine for Lewy Body Diseases
Modulates Patient's Immune System to Reduce Lewy Body Protein AggregatesThis therapeutic vaccine treats Lewy body diseases, such as Parkinson’s disease, by clearing misfolded protein aggregates utilizing a patient's own immune system. An estimated 1.4 million people in the U.S. suffer from Lewy body dementia, making it the second most frequent...
Published: 6/27/2021   |   Inventor(s): Michael Okun, Vinata Vedam-Mai, Catherine Flores, Duane Mitchell
Keywords(s): Adoptive cell therapy, alpha-synuclein, Cell Therapy, lewy body disease
Category(s): Technology Classifications > Human Health Care > Others, Technology Classifications > Human Health Care > Therapeutics