Search Results - chenming+(mike)+zhang

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VALUE PROPOSITION Rail transportation is periodically marred by accidents, highlighting ongoing safety challenges. There is a need for effective rail inspection methods. Current techniques are hindered by limitations such as low detection accuracy and sensitivity, particularly at high speeds. This technology introduces a novel method for high-speed,...

Published: 9/27/2024 | Inventor(s): Yiming Deng, Sunil Chakrapani, Ming Han, Zebadiah Miles

Keywords(s):

Category(s): Analytical Instruments, Test and Measurement, Transportation

Nanoparticle-based Nicotine Nanovaccine

THE CHALLENGE: Tobacco smoking is one of the largest public health threats the world has ever faced and results in over seven million deaths annually world wide. Smoking cessation is a difficult and largely unsuccessful undertaking; only 3-5% of unassisted smokers are able to remain abstinent for more than six months, and the use of pharmacological...

Published: 7/15/2024 | Inventor(s): Chenming (mike) Zhang, Zongmin Zhao

Keywords(s):

Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics

Whole Tissue Protein Mapping

A tool and method for precise, high-throughput spatial mapping of proteins across whole tissue samples. Background: Spatial proteomics enables delineation of spatial localization of proteins within cells and tissues. This ability to identify and study the relative location and quantification of one or more proteins, whether ones that are endogenously...

Published: 8/21/2024 | Inventor(s): Jun Qu, Ming Zhang, Min Ma

Keywords(s): Featured, Technologies

Category(s): Campus > University at Buffalo, Technology Classifications > Bioinformatics

Nanopore Tweezer System for Protein Kinase Allosteric Drug Screening

PRODUCT OPPORTUNITIES AND END-USE APPLICATIONS • Nanopore-tweezer-based system for efficient kinase allosteric drug screening ADVANTAGES • Label-free method • Capable of identifying both allosteric inhibitors and activators • Capable of distinguishing active-site inhibitors from allosteric...

Published: 8/3/2023 | Inventor(s): Min Chen, Fanjun Li

Keywords(s):

Category(s): Biotechnology, Life Sciences, Research tools

Nanopore-based Sensors for Antibody Screening Applications

PRODUCT OPPORTUNITIES AND END-USE APPLICATIONS • Nanopore-based antibody screening system • Nanopore sensors for antibody detection and identification • Antibody screening in hybridoma-based antibody production • Real-time monitoring of antibody production in cell culture ADVANTAGES •...

Published: 6/26/2023 | Inventor(s): Min Chen, Joshua Foster, Minji Kim, Matthew Moore

Keywords(s):

Category(s): Devices & sensors, Life Sciences, Research tools

Novel Multi-Omics Aging Clock

A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...

Published: 3/12/2024 | Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools

Autonomous Drone for railroad track inspection

Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...

Published: 3/15/2023 | Inventor(s): Yu Qian, Yi Wang, Chen Chen

Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation

Category(s): Engineering and Physical Sciences

Method for 3D Nonlinear Structured Illumination Super-resolution Imaging

Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...

Published: 4/3/2023 | Inventor(s): Leilei Peng, Yu Li, Han Zhang

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry

Helical Sulfono-γ-AApeptide Antagonize β-Catenin Signaling

Competitive Advantages Potent, specific, and cell permeable to target intracellular PPIs High stability against enzymatic degradation More effective than other peptides at antagonizing Wnt/β-catenin signaling Summary Protein-protein interactions (PPIs) are vital to the survival of cancer cells and are therefore a good target for anti-cancer...

Published: 7/17/2023 | Inventor(s): Jianfeng Cai, Peng Sang, Yan Shi, Haitao Ji, Min Zhang

Keywords(s): Cancer, Cancer Treatment Leukemias, Cancer Treatment Lymphomas, Peptides, Therapeutics

Category(s): Technology Classifications > Cancer

Making Oligonucleotides Better Biopharmaceuticals with Brush Polymer-Assisted Compaction

INV-16006 Background Oligonucleotide-based gene therapy holds tremendous promise for treating a variety of disorders with a genetic basis, including cancers, neurological diseases, and metabolic conditions. However, due to difficulties including poor accumulation at target sites, removal by immune responses, nuclease degradation, and low biochemical...

Published: 10/15/2024 | Inventor(s): Ke Zhang, Xueguang Lu

Keywords(s):

Category(s): -Chemistry, -Cancer, Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Drug Delivery

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