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MKK3/MYC Protein-Protein Interaction Inhibitor Overcomes Resistant Non-Small Cell Lung Cancer
Application A therapeutic use for SGI-1027 in the treatment of Osimertinib-resistant non-small cell lung cancer (NSCLC). Key Benefits The MKK3/MYC protein-protein interaction inhibitor SGI-1027 effectively decreases MYC levels in Osimertinib-resistant NSCLC cell lines. The combination of SGI-1027 with Osimertinib offers synergistic benefits over...
Published: 10/15/2025   |   Inventor(s): Andrey Ivanov, Haian Fu, Shi-Yong Sun, Zhen Chen
Keywords(s): Drug Discovery, Oncology Treatments, Protein and Peptide Therapeutics
Category(s): TechPub Algolia > Therapeutics
AUTOMATED STRUCTURAL DAMAGE DETECTION AND LOCALIZATION USING MECHANICS-INFORMED DATA ANALYSIS
VAlue proposition Structural health monitoring ensures the safety and longevity of structures like buildings and bridges. As the volume and scale of structures and the impact of their failure continue to grow, there is a need for techniques that are scalable, inexpensive, can operate passively without human intervention, and are customized for each...
Published: 8/19/2025   |   Inventor(s): Vishnu Boddeti, Nizar Lajnef, Li Xuyang, Mahdi Masmoudi
Keywords(s):  
Category(s): Test and Measurement
Methods and Systems for Detecting Disinformation Generated by Large Language Models
Background The rapid dissemination of news is an important factor for the global population to stay up to date with current events, or to make well-informed decisions in dynamic sectors like the stock market. Journalists typically include large amounts of quantitative information using data visualization to help enhance accessibility and comprehension...
Published: 9/10/2025   |   Inventor(s): Bohan Jiang, Zhen Tan, Ayushi Nirmal, Huan Liu
Keywords(s): Data Mining, Disinformation, Large Language Model, Machine Learning
Category(s): Cybersecurity, Physical Science, Artificial Intelligence/Machine Learning
Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use
" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...
Published: 10/24/2025   |   Inventor(s): Li Niu, Zhen Huang
Keywords(s): Technologies
Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Campus, Campus > University at Albany
Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use
" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...
Published: 10/24/2025   |   Inventor(s): Li Niu, Zhen Huang
Keywords(s): Technologies
Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Campus, Campus > University at Albany
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases, such as post-stroke cellular...
Published: 10/24/2025   |   Inventor(s): Li Niu, Zhen Huang, Yan Han, Congzhou Wang, Jae Seon Park
Keywords(s): RNA, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus, Campus > University at Albany
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases, such as post-stroke cellular...
Published: 10/24/2025   |   Inventor(s): Li Niu, Zhen Huang, Yan Han, Congzhou Wang, Jae Seon Park
Keywords(s): RNA, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus, Campus > University at Albany
Drug Candidate for ALS
RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...
Published: 10/24/2025   |   Inventor(s): Li Niu, Zhen Huang
Keywords(s): ALS, amyotrophic lateral sclerosis, aptamers, drug design, Lou Gehrig's disease, MND, motor neurone disease, RNA
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany
Drug Candidate for ALS
RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...
Published: 10/24/2025   |   Inventor(s): Li Niu, Zhen Huang
Keywords(s): ALS, amyotrophic lateral sclerosis, aptamers, drug design, Lou Gehrig's disease, MND, motor neurone disease, RNA
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany
Solvent-resistant Self-crosslinked Poly(ether imide)s
THE CHALLENGE One of the major challenges facing the commercialization of high-performance polymers like poly(ether imide) lies in balancing their excellent thermal and mechanical properties with the need for strong resistance to harsh organic solvents—an essential requirement in industries such as coatings, electronics, and membranes. While...
Published: 6/25/2025   |   Inventor(s): Guoliang Liu, Zhen Xu, Alan Esker, Gehui Liu
Keywords(s):  
Category(s): Technology Classifications > Chemicals/Materials
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