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Search Results - yuqing+liu
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Microneedle array coating technology for enhanced stability and targeted delivery of mRNA and biologics
A microneedle-based system uses cryogenically pre-cooled needles coated via thin-film freeze-coating to preserve mRNA stability, enabling efficient, multi-therapeutic intradermal delivery of temperature-sensitive drugs. Background The field of advanced drug delivery systems has grown substantially as the biomedical industry grapples with the complexities...
Published: 1/27/2026
|
Inventor(s):
Zhengrong Cui
,
Michael Sandoval
,
Robert Williams
,
Drew Weissman
,
Qin Li
Keywords(s):
Category(s):
Life sciences > Therapeutics > Drug discovery
Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025
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Inventor(s):
Li Li
,
Shichao Wu
,
Jiawei Zhao
Keywords(s):
Category(s):
Technology Category > Research tools
,
Technology Category > Animal models
,
Technology Category > Biology
,
Technology Category > Diagnostic
Multi-domain Hardware Memory Compression
THE CHALLENGE In hyperscale data centers, the most expensive component in CPU-based servers, in terms of both monetary cost and carbon footprint, is currently computer memory; going forward, memory is expected to become even more expensive relative to other server components. Hardware memory compression, where the CPU’s memory controller transparently...
Published: 12/1/2025
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Inventor(s):
Xun (Steve) Jian
,
Gagandeep Panwar
,
Muhammad Laghari
,
Yuqing Liu
Keywords(s):
Category(s):
Technology Classifications > Computer Science
,
Technology Classifications > Software
Demand-adaptive Memory Compression in Hardware
THE CHALLENGE The density scaling of computer memory has lagged behind central processing units (CPUs) and storage creating a cost bottleneck in data centers and cloud computing. To help logically scale up memory density, operating systems (OSes) today compress and pack more values into the same physical amount of memory. To minimize the impact on...
Published: 10/24/2025
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Inventor(s):
Xun (Steve) Jian
,
Gagandeep Panwar
,
Muhammad Laghari
,
Yuqing Liu
Keywords(s):
Category(s):
Technology Classifications > Computer Science
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 2/13/2025
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Inventor(s):
Li Liu
,
Jingmin Shu
Keywords(s):
Category(s):
Applied Technologies
,
Genomic Assays/Reagents/Tools
,
Life Science (All LS Techs)
,
Diagnostic Assays/Devices
Recovering Critical Elements from Acid Mine Drainage
THE CHALLENGE The demand for certain elements, such as Manganese (Mn), Cobalt (Co), and Nickel (Ni), has surged in recent years due to the rapid growth of battery production for electric vehicles and utility-scale energy storage. The United States government has deemed Co, Ni, and Mn critical elements, primarily because of the country’s high...
Published: 10/17/2025
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Inventor(s):
Wencai Zhang
,
Qi Li
,
Rick Honaker
Keywords(s):
Category(s):
Technology Classifications > Energy
,
Technology Classifications > Mining and Recycling
,
Technology Classifications
,
Technology Classifications > Chemicals/Materials
Novel Anti-HIV Compounds Using Peptides or Peptide Mimetics
Abstract: The subject invention describes a new class of compounds (such as peptides or mimetics) that target viral RNAs and inhibit the viral life cycle by blocking the viral recognition process. More specifically, these compounds are the first against an RNA Target - currently there are no clinical drugs against RNA targets in the treatment of any...
Published: 4/22/2025
|
Inventor(s):
Yun-Xing Wang
,
Liu Yu
,
Ping Yu
,
Ina O'Carroll
Keywords(s):
Anti-Viral
,
HIV
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Infectious Disease
Method and Device for Selectively Labeling RNA
Abstract: Current methods of labeling and synthesizing RNA do not allow for multiple labels or long RNA segments to be synthesized for large RNA on a milligram scale. Investigators at the NCI Structure Biophysics Lab and UT Health Science Center have developed a method to selectively label RNA at specific residues and/or segments using a hybrid solid-liquid...
Published: 4/22/2025
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Inventor(s):
Yun-Xing Wang
,
Liu Yu
,
Rui Sousa
Keywords(s):
crystallography
,
Fluorophore labeling
,
FRET
,
Isotope labeling
,
Labeling sensor
,
NMR Spectroscopy
Category(s):
Application > Diagnostics
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
Real-Time RT-PCR Assay for the Rapid Detection of Rabies and Other Lyssaviruses
Rabies occurs in more than 150 countries and territories, resulting in at least 55,000 human deaths per year worldwide according to World Health Organization estimates. Rabies is a vaccine-preventable viral disease caused by numerous lyssaviruses that are found in a variety of animal species throughout the world. Rabies virus infects the central nervous...
Published: 4/24/2025
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Inventor(s):
Yu Li
Keywords(s):
assay
,
DA4XXX
,
DDXXXX
,
Diagnostics
,
LYSSAVIRUSES
,
Modified
,
NCEZID
,
NCEZID-DHCPP
,
Non-rabies
,
Probe
,
rabies
,
REAL-TIME
,
RT-PCR
,
VLXXXX
,
VOXXXX
,
WBXXXX
,
WGXXXX
,
WHXXXX
,
WIXXXX
,
XEXXXX
,
YBXXXX
,
YGXXXX
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Occupational Safety and Health
,
TherapeuticArea > Infectious Disease
,
Application > Consumer Products
,
Application > Therapeutics
,
Application > Research Materials
,
Application > Diagnostics
Universal Diagnostic Assay for Detection and Identification of Poxviruses in Clinical Samples
CDC researchers have developed an assay for detection and diagnosis of poxviruses within clinical samples or from lab culture-systems. The assay specifically targets chordopoxviruses (except avipoxviruses) for PCR-based identification; an improvement upon the current standard of cell culturing methodologies. Individual chordopoxvirus species can cause...
Published: 4/24/2025
|
Inventor(s):
Inger Damon
,
Hui Zhao
,
Yu Li
Keywords(s):
ASSAYS
,
CDC Docket Import
,
CDC Docket Import CDC Prosecuting
,
CHORDOPOXVIRUSES
,
DA4BXX
,
DA4XXX
,
DAXXXX
,
diagnostic
,
DXXXXX
,
OID-NCEZID-DHCPP
,
VLXXXX
,
VOXXXX
,
WBXXXX
,
WFXXXX
,
WIXXXX
,
WMXXXX
,
XCXXXX
,
XEXXXX
,
YBXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Occupational Safety and Health
,
Application > Therapeutics
,
TherapeuticArea > Infectious Disease
,
Application > Consumer Products
,
Application > Diagnostics
,
Application > Research Materials
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