Search Results - xinyu+zhou

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Optical Imaging Platform for POC CAR T-Cell Therapy Assessment
Chimeric antigen receptor (CAR) T-cell therapy is a type of immunotherapy which uses altered T-cells to target cancer cells more effectively. As such, it has dramatically changed the treatment landscape for cancer patients. However, it has limitations including cytokine release syndrome (CRS), neurological events (NE), lack of response (which occurs...
Published: 8/27/2024   |   Inventor(s): Shaopeng Wang, Nanxi Yu, Chao Chen, Xinyu Zhou, Januario Castro, Eider Moreno Cortes
Keywords(s):  
Category(s): Medical Diagnostics/Sensors, Medical Devices, Life Science (All LS Techs), Imaging, Cancer, Bioanalytical Assays, Chemistries & Devices
BIOSENSOR DETECTION ASSAY FOR ANTI-SARS-COV-2 ANTIBODIES
BIOSENSOR DETECTION ASSAY FOR ANTI-SARS-COV-2 ANTIBODIES Researchers at UCSF and the Chan Zuckerberg Biohub have developed a serological detection assay for anti-SARS-CoV-2 antibodies. COVID-19, caused by the SARS-CoV-2 virus, has spread throughout the world. Early detection of disease using viral detection assays is critical for containing the spread...
Published: 3/17/2023   |   Inventor(s): James Wells, Susanna Elledge, Xin Zhou
Keywords(s): Antibody, Biosensor System, Diagnosis, Epitope Shield, IgG
Category(s): Technology Classifications > Biology
ENGINEERED ACE2 RECEPTOR TRAPS TO BLOCK SARS-COV-2 INFECTION
ENGINEERED ACE2 RECEPTOR TRAPS TO BLOCK SARS-COV-2 INFECTION Researchers at UCSF and the Chan Zuckerberg Biohub have developed a set of ACE2 variants which potently block SAR-CoV-2 infection in cells. SARS-CoV-2 is the stain of coronavirus that causes COVID-19. This virus is characterized by spike proteins on its surface, which mediate infection...
Published: 3/17/2023   |   Inventor(s): James Wells, Tanja Kortemme, Jeff Glasgow, Anum Glasgow, Irene Lui, Xin Zhou
Keywords(s): Affinity Reagent, Biomolecules, Therapeutic, Yeast Particle Display
Category(s): Technology Classifications > Biology
DETECTION ASSAY FOR SARS-COV-2 VIRUS
DETECTION ASSAY FOR SARS-COV-2 VIRUS Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to detect SARS-CoV-2 virus. Clinical laboratory tests and point-of-care tests are needed for screening and diagnosis of individuals infected with SARS-CoV-2 virus. SARS-CoV-2 infection begins with viral Spike protein binding to the human...
Published: 3/17/2023   |   Inventor(s): James Wells, Susanna Elledge, Xin Zhou, Tanja Kortemme, Jeff Glasgow, Anum Glasgow, Irene Lui
Keywords(s): Affinity Reagent, Antibody, Biosensor System, Diagnosis, Fc Domain
Category(s): Technology Classifications > Biology
Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers
A) Novel mechanism of action: a short exposure to ZMCs increases zinc levels in tumors enough to restore normal structure/function to mutant p53 which leads to p53 mediated cancer cell death. B) Novel formulation: Synthesizing ZMCs as a zinc-loaded complex (Zn-1) improves survival in a pancreatic cancer mouse model compared to the ZMC compound alone....
Published: 9/1/2022   |   Inventor(s): Darren Carpizo, David Augeri, Spencer Kimball, Xin Yu
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 2/23/2023   |   Inventor(s): Alexander Green, Yu Zhou
Keywords(s): Bio-Technology
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools