Search Results - abraham+sonenshein

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Oral Spore Vaccines AGainst Clostridium Difficile Infection
Competitive Advantages Targets main virulent factors Reduces distribution of toxigenic spores Improved efficacy No need for cold storage Summary USF researchers have designed an oral vaccine to protect users against C. difficile infection. This vaccine uses non-toxigenic C. difficile (NTCD) strains to carry non-pathogenic toxin fragments. These...
Published: 8/25/2023   |   Inventor(s): Xingmin Sun, Abraham Sonenshein
Keywords(s):  
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Inhibitors of Clostridium difficile spore germination and outgrowth
Inhibitors of Clostridium difficile spore germinationTufts case T001523Technology• Spore formation by Clostridium difficile is a significant obstacle to overcoming hospital-acquired C. difficile-associated disease (CDAD). Spores are resistant to heat, radiation, chemicals, and antibiotics, making a contaminated environment difficult to clean....
Published: 3/19/2021   |   Inventor(s): Abraham Sonenshein, Joseph Sorg
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Category(s): Diseases: infectious, Screening: target, Therapeutic: antibiotic, Therapeutic: small molecule
Spore Vaccine for Rotavirus
Heat-stable, injection-free vaccine platformThe invention is a novel vaccine platform utilizing the non-pathogenic bacterium Bacillus subtilis as the antigen-producer. A desired antigen can be engineered to be under the control of a pro-vegetative state or a pro-sporulation promoter. Cells are induced to express the desired antigen on the cell surface...
Published: 7/30/2021   |   Inventor(s): John Herrmann, Abraham Sonenshein, Saul Tzipori, Boris Belitsky
Keywords(s):  
Category(s): Therapeutic: vaccine
Research Tool: Stable reporter system for promoter activity in Listeria monocytogenes
Stable reporter system for promoter activity in Listeria monocytogenes
Published: 4/2/2020   |   Inventor(s): Abraham Sonenshein, Hyun-Jin Kim
Keywords(s):  
Category(s): Research tool: expression system