Search Results - xiaosong+wang

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The First Curative Treatment of Phenylketonuria Using Genetic Engineering Approaches
The base editing of phenylalanine hydroxylase enzyme in the liver to restore phenylalanine metabolism and prevent neurotoxic effects. Problem: Phenylketonuria (PKU) is a severe disorder affecting approximately 1 in 10,000 U.S. newborns. PKU is marked by a genetic mutation in the phenylalanine hydroxylase enzyme (PAH), resulting in phenylalanine (Phe)...
Published: 10/28/2024   |   Inventor(s): Kiran Musunuru, Xiao Wang, Dominique Brooks
Keywords(s): Gene Editing, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Neurology
Category(s): Technology Classifications > Therapeutics
LNP Delivery of Gene-Editing Machinery to Cure Hereditary Tyrosinemia Type 1g
Problem: Hereditary tyrosinemia type 1 (HT1) is a genetic metabolic disease caused by the inability to break down tyrosine, an amino acid present in many meats, dairy products, fruits, and nuts. This disease can be fatal within the first few months of life and increases the risk of liver cancer. The current treatment involves a strict drug regimen and...
Published: 7/10/2024   |   Inventor(s): Kiran Musunuru, Madelynn Whittaker, Xiao Wang, William Peranteau, Cara Berkowitz, Ana Dumitru
Keywords(s): Gene Editing, Genetic Disorders, Obesity, Metabolic Disease and Diabetes
Category(s): Technology Classifications > Therapeutics
Convolutional Neural Networks for Organ Segmentation
Abstract: Accurate automated organ and disease feature segmentation is a challenge for medical imaging analysis. The pancreas, for example, is a small, soft, organ with low uniformity of shape and volume between patients. Because of the lack of uniform image patterns, there are few features that can be used to aid in automated identification of anatomy...
Published: 4/8/2024   |   Inventor(s): Le Lu, Holger Roth, Isabelle-Emmanu Nogues, Ronald Summers, Xiaosong Wang
Keywords(s): Computer Assisted Diagnostics, Computer Vision, Deep Learning, HNN, Holistically-Nested Convolutional Neural Network, Medical Imaging Informatics, National Institutes of Health Clinical Center, NIHCC
Category(s): Application > Software / Apps, Collaboration Sought > Licensing
Method and System of Building Hospital-Scale Medical Image Database
Abstract: Developing computer systems that can recognize and locate image features associated with disease is a challenge for developing fully-automated and high precision computer assisted diagnostics. Joint learning of language tasks in association with vision tasks (association of image features with text annotation) adds an additional level of challenge. ...
Published: 4/8/2024   |   Inventor(s): Xiaosong Wang, Yifan Peng, Le Lu, Zhiyong Lu, Ronald Summers
Keywords(s): Computer Assisted Diagnostics, Computer Vision, Deep Learning, Medical Imaging Informatics, National Institutes of Health Clinical Center, NIHCC, PACS, Picture Archiving and Communication Systems
Category(s): Collaboration Sought > Licensing, Application > Software / Apps
Synthetic Gene Circuits
­Engineering synthetic gene circuits allows scientists to design cells to perform any number of tasks such as biosensing, therapeutic or commodity production or bioremediation to name a few. An important design principle when engineering sophisticated synthetic gene circuits is modularity as it breaks the system down into small modules, thereby...
Published: 2/23/2023   |   Inventor(s): Rong Zhang, Hanah Goetz, Juan Melendez-Alvarez, Xiao Wang, Xiaojun Tian
Keywords(s):  
Category(s): Computing & Information Technology, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
A Mutually Inhibitory Network with Positive Autoregulation and Communications (MINPAC)
Biological pattern formation requires complex gene regulation networks and accurate cell-cell coordination. The reaction-diffusion (RD) based clock and wavefront model has been proposed as a mechanism involved in biological pattern formation of repeated and segmented structures. While RD driven pattern formation has been demonstrated in many systems,...
Published: 2/23/2023   |   Inventor(s): Fuqing Wu, Samat Bayakhmetov, Changhan He, Qi Zhang, Xingwen Chen, Yang Kuang, Xiao Wang
Keywords(s):  
Category(s): Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Computing & Information Technology
Base-Edited Isogenic hPSC Line Generation (BIG-TREE)
Human pluripotent stem cells (hPSCs) are a vital tool not only in research and disease modeling but also in developmental biology and regenerative medicine because of their ability to self-renew and differentiate. Current genome editing tactics in hPSCs require the incorporation of deleterious double-stranded DNA breaks followed by inefficient homology-directed...
Published: 2/23/2023   |   Inventor(s): David Brafman, Xiao Wang, Nicholas Brookhouser, Stefan Tekel, Kylie Standage-Beier
Keywords(s):  
Category(s): Life Science (All LS Techs), Genomic Assays/Reagents/Tools
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 2/23/2023   |   Inventor(s): Qi Zhang, Xiao Wang, Alexander Green, Duo Ma, Fuqing Wu, Kylie Standage-Beier, Xingwen Chen
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
Targeted Remodeling of Bacterial Genomes Using CRISPR-Nickases
Targeting DNA manipulation is integral to biotechnology and synthetic biology. Large chromosomal rearrangements and deletions have profound impacts on bacterial physiology, such as improved bioproduct levels, increased strain fitness, or changed tolerance to stress and environmental conditions. However, it requires time-consuming and laborious directed...
Published: 2/23/2023   |   Inventor(s): Xiao Wang, Kylie Standage-Beier
Keywords(s): Biological Cell Manipulation, Bio-Technology
Category(s): Alternative Energy/Biofuels/Bioplastics/Algae, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Model for Gene Expression Tuning and Synthetic Gene Circuit Construction
Genetic circuit engineering has played an important role in many forms of synthetic biology. Based on a large collection of well characterized biological components, complex gene circuits with designed functions can be wired using established biological principles. Currently circuit assembly has two main strategies: one is monocistronic construct, in...
Published: 2/23/2023   |   Inventor(s): Fuqing Wu, Xiao Wang, Qi Zhang
Keywords(s):  
Category(s): Computing & Information Technology, Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Life Science (All LS Techs)
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