Search Results - xiaoqin+wang

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LNP Delivery of Gene-Editing Machinery to Cure Hereditary Tyrosinemia Type 1g

Problem: Hereditary tyrosinemia type 1 (HT1) is a genetic metabolic disease caused by the inability to break down tyrosine, an amino acid present in many meats, dairy products, fruits, and nuts. This disease can be fatal within the first few months of life and increases the risk of liver cancer. The current treatment involves a strict drug regimen and...

Published: 7/10/2024 | Inventor(s): Kiran Musunuru, Madelynn Whittaker, Xiao Wang, William Peranteau, Cara Berkowitz, Ana Dumitru

Keywords(s): Gene Editing, Genetic Disorders, Obesity, Metabolic Disease and Diabetes

Category(s): Technology Classifications > Therapeutics

Therapeutic Inhibition of Molecular Drivers of Microglial Reactivity in Neurodegenerative Disease

It is estimated that over 55 million people have Alzheimer’s disease (AD) or other dementias, and despite their rapidly increasing burden, thus far there are no disease modifying therapeutics available. Novel therapeutic strategies are urgently needed to address the prevention and treatment of AD. Mounting evidence from large scale genetic studies...

Published: 2/14/2024 | Inventor(s): Benjamin Readhead, Qi Wang, Diego Mastroeni, Eric Reiman

Keywords(s):

Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies

Stable Biological Membrane Mimetic For Enhanced Protein Recruitment

Synthetic biological alternative to natural lipids for conjugation with nitrilotriacetic acid (NTA) for enhanced His-tagged protein interaction and long-term stability. Problem: Biomimetic lipid vesicles, such as liposomes, have multiple biotechnology and drug delivery applications as their lipid bilayer innately interacts with natural cell membranes....

Published: 10/16/2023 | Inventor(s): Virgil Percec, Qi Xiao, Matthew Good

Keywords(s): Bioengineering, Platform Technology

Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents

The Closed Loop Comfort-Cost Control Thermostat and Monitor

This technology utilizes a novel management framework for thermostats targeted towards the end-user. Using a data-driven prediction component to learn data relationships, this technology predicts future HVAC loads within a given time frame. In its totality, the cost-effective hardware monitor with cloud-based computation and control calculations has...

Published: 8/1/2024 | Inventor(s): Jonathan Sprinkle, Xiao Qin, Susan Lysecky

Keywords(s):

HVAC Prediction Software for a Cost-Limited Home Thermostat

This technology interacts with a homeowner's heating and cooling system to provide a cost-effective HVAC prediction. Employing algorithms, software and hardware, this technology interprets budget and cost inputs from the homeowner and provides comfort suggestions that fit those budget parameters by correlating temperature with cost. This technology...

Published: 8/1/2024 | Inventor(s): Jonathan Sprinkle, Susan Lysecky, Xiao Qin

Keywords(s): building monitoring, building optimization, computer-aided design, control, human computer interaction, HVAC, modeling and simulation, thermostat

Category(s): Technology Classifications > Engineering & Physical Sciences, Technology Classifications > Energy, Cleantech & Environmental, Technology Classifications > Energy, Cleantech & Environmental > Low Carbon, Technology Classifications > Engineering & Physical Sciences > Electronics, Technology Classifications > Engineering & Physical Sciences > Electronics > Digital Circuits

HVAC Prediction for a Cost-Limited Home Thermostat

This technology addresses this problem by introducing a new cost-limited thermostat which provides real-time feedback on temperature-cost correlation and puts consumers in control of balancing their comfort and budget. When the temperature schedule or monthly budget is changed, the thermostat immediately displays how one affects the other allowing the...

Published: 8/1/2024 | Inventor(s): Jonathan Sprinkle, Susan Lysecky, Xiao Qin

Keywords(s): air-conditioner, energy, HVAC, prediction, thermostat

Synthetic Gene Circuits

Engineering synthetic gene circuits allows scientists to design cells to perform any number of tasks such as biosensing, therapeutic or commodity production or bioremediation to name a few. An important design principle when engineering sophisticated synthetic gene circuits is modularity as it breaks the system down into small modules, thereby...

Published: 2/23/2023 | Inventor(s): Rong Zhang, Hanah Goetz, Juan Melendez-Alvarez, Xiao Wang, Xiaojun Tian

Keywords(s):

Category(s): Computing & Information Technology, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)

A Mutually Inhibitory Network with Positive Autoregulation and Communications (MINPAC)

Biological pattern formation requires complex gene regulation networks and accurate cell-cell coordination. The reaction-diffusion (RD) based clock and wavefront model has been proposed as a mechanism involved in biological pattern formation of repeated and segmented structures. While RD driven pattern formation has been demonstrated in many systems,...

Published: 2/23/2023 | Inventor(s): Fuqing Wu, Samat Bayakhmetov, Changhan He, Qi Zhang, Xingwen Chen, Yang Kuang, Xiao Wang

Keywords(s):

Category(s): Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Computing & Information Technology

Base-Edited Isogenic hPSC Line Generation (BIG-TREE)

Human pluripotent stem cells (hPSCs) are a vital tool not only in research and disease modeling but also in developmental biology and regenerative medicine because of their ability to self-renew and differentiate. Current genome editing tactics in hPSCs require the incorporation of deleterious double-stranded DNA breaks followed by inefficient homology-directed...

Published: 2/23/2023 | Inventor(s): David Brafman, Xiao Wang, Nicholas Brookhouser, Stefan Tekel, Kylie Standage-Beier

Keywords(s):

Category(s): Life Science (All LS Techs), Genomic Assays/Reagents/Tools

Pathogen Molecular Detection Platform

Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...

Published: 2/23/2023 | Inventor(s): Qi Zhang, Xiao Wang, Alexander Green, Duo Ma, Fuqing Wu, Kylie Standage-Beier, Xingwen Chen

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors

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