Search Results - william+robert+taylor

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Metabolically stable HDAC inhibitors with trifluoromethylpyruvamide as metal-binding group
Project ID: TECH-2023-25 Background Histone Deacetylases (HDACs) have been studied extensively for their role in regulating expression of genes and proteins involved in cancer cell proliferation and migration. The Zinc Binding Group (ZBG) is an essential component of the HDAC inhibitor pharmacophore. It binds to the zinc ion in the enzyme active...
Published: 5/21/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, Endri Karaj, Riddhidev Banerjee, William Taylor
Keywords(s):  
Category(s): Oncology
Novel Ferroptosis Inducers To Treat Cancer
Project ID: D2022-15 Background ferroptosis is a non-apoptotic cell death mechanism impelled by unrestrained accumulation of iron-dependent cellular reactive oxygen (ROS) species leading to membrane lipid peroxidation resulting from intra-cellular antioxidant depletion. Clinical application of ferroptosis agents/drugs has been elusive due to off-target...
Published: 6/18/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, Samkeliso Dlamini, William Taylor
Keywords(s):  
Category(s): Oncology
Precursor PET Compound for Imaging Infections
Application Diagnostic molecules for detecting bacterial infections using nuclear imaging. Key Benefits May improve the detection of infections within the body. Potentially facilitates earlier treatment and superior clinical outcomes compared to other diagnostic radiotracers. Market Summary The rising incidences of bacterial infections resistant...
Published: 10/17/2024   |   Inventor(s): Mark Goodman, William Robert Taylor, Wone Woo Seo, Malgorzata Lipowska
Keywords(s): Imaging, Imaging Agents
Category(s): TechPub Algolia > Diagnostics
Ferroptosis-HDAC Inhibitor Hybrids for treating cancer
Project ID: D2022-16 Background Many cancer treatments target cells and induce apoptosis, a cell death mechanism. Due to genetic instability, tumors become more heterogeneous leading to cells that avert molecular signatures that are targeted by the cancer drugs. Drug resistance remains a major impediment to the success of a cancer treatment. Combinatorial...
Published: 6/18/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, Endri Karaj, Shaimaa Sindi, William Taylor
Keywords(s): Cancer, Drug-resistance, HDAC inhibitors, Histone deacetylases , Non-apoptotic cell death
Category(s): Oncology
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Power-Generating Thermogalvanic Bricks
Background Buildings account for approximately 40% of all energy consumed, with ever-increasing demand from new embedded electronic devices. Meeting these energy requirements involves consideration of both practical and environmental concerns. Modern solar arrays, for example, can offer an independent, off-grid power source that can be well suited...
Published: 2/23/2023   |   Inventor(s): Leigh Aldous, Patrick Phelan, Robert Taylor, Benjamin Obeng
Keywords(s): Fuel Cells, Energy
Category(s): Manufacturing/Construction/Mechanical, Alternative Energy, Environmental, Physical Science
Small Drug-like Molecules as Anticancer Agents for NSCLC
Project ID: D2013-04Background Lung cancer is the leading cause of cancer deaths in the United States. More than 80% of the lung cancer deaths belong to non-small cell lung cancer (NSCLC). The 5-year survival rate of patients with NSCLC is about 16% with current treatments including surgery, radiation and other classic chemotherapeutic agents and targeted...
Published: 6/18/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, William Taylor, Sara Fedorka
Keywords(s): Anticancer, Hydroxyurea, NSCLC, Taxol
Category(s): Oncology
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
Tempol-Folate Conjugates to Prevent Oxidative Injury in Tissues
Application Targeted anti-oxidative therapy for ischemia-reperfusion injury, hemorrhage, major surgery, kidney transplant, or acute renal failure. Key Benefits Conjugation of Tempol with Folate does not alter the antioxidant property of Tempol. Tempol-Folate conjugates are more effective than Tempol alone at preserving kidney structure and function...
Published: 9/26/2024   |   Inventor(s): Sarah (Knight) Marvar, William Robert Taylor, Niren Murthy, Kousik Kundu
Keywords(s): Nephrology, Urology
Category(s): TechPub Algolia > Therapeutics
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