Search Results - anticancer

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Discovery of imidazo[1,2-b]pyridazines with Anticancer Properties
This technology includes a series of imidazo[1,2-b]pyridazines that display potent inhibition of FLT3, as well as potent binding and activity against FLT3 tyrosine kinase domain and gatekeeper mutations. This chemotype exhibits superior anti-leukemic activity against the common clinically-relevant FLT3-mutant acute myeloid leukemia (AML) in vitro and...
Published: 7/25/2024   |   Inventor(s): Scott Hoyt, Patrick Sutter, Chris Finocchio, Daniel Starczynowski, Gregory Tawa, Craig Thomas
Keywords(s): 2-b]pyridazines, ANTICANCER, Discovery, Imidazo[1, PROPERTIES, VCXXXX, WIXXXX, WKXXXX
Category(s): Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology
Vitamin D Receptor Antagonists for Treating Breast Cancer
Vitamin D receptor (VDR) is a nuclear receptor that is activated by calcitriol, the active form of vitamin D. It is best known for regulating dietary calcium uptake necessary for bone growth, but it also affects cell proliferation and differentiation. Therefore, it was thought that treatment with calcitriol or its derivatives could be useful to treat...
Published: 4/8/2024   |   Inventor(s): Julianna Barsony
Keywords(s): ANTAGONISTS, ANTICANCER, CB7XXX, CBXXXX, CXXXXX, D, EFFECTS, Glioma, Novel, RECEPTOR, Vitamin
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Small Drug-like Molecules as Anticancer Agents for NSCLC
Project ID: D2013-04Background Lung cancer is the leading cause of cancer deaths in the United States. More than 80% of the lung cancer deaths belong to non-small cell lung cancer (NSCLC). The 5-year survival rate of patients with NSCLC is about 16% with current treatments including surgery, radiation and other classic chemotherapeutic agents and targeted...
Published: 6/18/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, William Taylor, Sara Fedorka
Keywords(s): Anticancer, Hydroxyurea, NSCLC, Taxol
Category(s): Oncology