Search Results - niren+murthy

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Polyketal Nanoparticles to Administer Pharmaceutical Products in Acidic Environments
Application Acid-sensitive polyketal nanoparticles for biodegradable drug delivery. Key Benefits Can be engineered to a variety of sizes and shapes to facilitate the delivery of hydrophobic small molecules, proteins, or nucleic acids. Provides a vehicle for delivering therapeutics to acidic environments found in tumors, inflammatory tissues, and...
Published: 8/22/2024   |   Inventor(s): Niren Murthy, Bali Pulendran, Michael Heffeman, Jihua Hao, Marcin Kwissa, Michael E. Davis, Stephen Chen Yang
Keywords(s): Drug Delivery, Small Molecule
Category(s): TechPub Algolia > Vaccines
Tempol-Folate Conjugates to Prevent Oxidative Injury in Tissues
Application Targeted anti-oxidative therapy for ischemia-reperfusion injury, hemorrhage, major surgery, kidney transplant, or acute renal failure. Key Benefits Conjugation of Tempol with Folate does not alter the antioxidant property of Tempol. Tempol-Folate conjugates are more effective than Tempol alone at preserving kidney structure and function...
Published: 7/30/2024   |   Inventor(s): Sarah (Knight) Marvar, William Robert Taylor, Niren Murthy, Kousik Kundu
Keywords(s): Nephrology, Urology
Category(s): TechPub Algolia > Therapeutics
Polyketal Nanoparticles (PKNs): a Novel Macrophage-Selective Drug-Delivery System
ApplicationsPolykeltal nanoparticles (PKNs) represent a novel and effective drug delivery vehicle, which appear to target macrophages selectively. Currently, PKNs can be used to incorporate any lipophilic pharmaceutical or lipophilic peptide. Inventors are now working on adapting the reverse-phase emulsion technique which will allow for the incorporation...
Published: 5/7/2024   |   Inventor(s): Niren Murthy, Bali Pulendran, Robert Pierce
Keywords(s): Therapy
Category(s): Therapeutic