Search Results - tianlei+ying

4 Results Sort By:
Human Antibodies Against Middle East Respiratory Syndrome Coronavirus
Abstract: No effective therapeutics or vaccines against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) are available. The human-to-human aspect of transmission and the high mortality rate associated with MERS-CoV infection have raised concerns over the potential for a future MERS-CoV pandemic and emphasized the need for development of effective...
Published: 5/22/2024   |   Inventor(s): Dimiter Dimitrov, Tianlei Ying, Tina Ju, Kwok Yuen
Keywords(s): ANTIBODY, CORONAVIRUS, MERs, middle east respiratory syndrome
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
Cancer Therapies Using Engineered Monomeric Fc Molecules
Abstract: The National Cancer Institute, Nanobiology Program seeks parties interested in collaborative research to co-develop engineered molecules therapies. Efforts to engineer antibody-based therapeutics, to date, have encountered technical limitations due to the relatively large fragment size and short fragment half-life. Antibody fragments are emerging...
Published: 5/22/2024   |   Inventor(s): Dimiter Dimitrov, Tianlei Ying
Keywords(s): FcRn, IgG1, mabs, MFC, neonatal Fc receptor
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
Fusion Proteins as HIV-1 Entry Inhibitors
Abstract: Soluble forms of human CD4 (sCD4) inhibit HIV-1 entry into immune cells.  Different forms of sCD4 and their fusion proteins have been extensively studied as promising HIV-1 inhibitors – including in animal models and clinical trials.  However, they have not been successful in human studies due to their transient efficacy.  sCD4 is also known...
Published: 5/22/2024   |   Inventor(s): Dimiter Dimitrov, Weizhao Chen, Tianlei Ying
Keywords(s): antibody dependent cellular cytotoxicity (ADCC), Class II major histocompatibility complex (MHCII), Dimitrov, fusion protein, HIV-1, sCD4
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
Peer-to-Peer Architecture for Processing Big Data
Big data is collected and analyzed by organizations everywhere to help make more accurate predictions and decisions. However, big data is useless without sufficient infrastructure for accessing, storing, and transferring the increasingly massive data sets. Current architectures rely on a centralized job scheduler and resource allocator, where a few...
Published: 2/23/2023   |   Inventor(s): Lei Ying, Weina Wang, Matthew Barnard
Keywords(s): Fuel Cells, Energy, Medical Devices and Imaging, Networks, IT, Software and Communication
Category(s): Computing & Information Technology