Search Results - vector%2fplasmid

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Enhancing Gene Silencing by RNAi
NU 2005-063, NU 2005-064, and NU 2006-182 InventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well...
Published: 9/12/2024   |   Inventor(s):  
Keywords(s): Biologic, Gene therapy, Infectious disease, Research tool, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Therapeutics
Microfluidic Device for Live Cell Manipulation and Analysis
NU 2020-191 INVENTORS Horacio Espinosa* Milan Mrksich* Prithvijit Mukherjee Eric Berns Cesar Patino SHORT DESCRIPTION A microfluidic platform for manipulation and analysis of live cells by delivering molecules or extracting and analyzing their internal contents at multiple timepoints without killing them ABSTRACT Current methods for investigating...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Devices, Microfluidics, Research tool, Vector/Plasmid
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
HPS1 and HPS4 Function as RNAi Inhibitors: A Means to Boost RNAi for Experimental, Therapeutic & Commercial Purposes
NU 2005-063BInventorsRichard Carthew* Dinari Harris Young Sik Lee Short DescriptionNovel strategy to improve gene silencing by RNAi for development of therapeutics AbstractRNAi has been proposed as a therapeutic strategy for disorders characterized by aberrant gene overexpression (cancer, macular degeneration etc.) as well as for controlling viral infections....
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Assay, Biologic, Gene therapy, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Therapeutics
Human Lamin Expression Vectors
NU 1997-011 InventorsRobert Goldman* Robert Moir Short DescriptionProtein expression vectors for all three human nuclear lamin proteins AbstractNorthwestern scientists have developed protein expression vectors for recombinant production of nuclear lamins in Escherichia coli. There are at least 3 lamin proteins in human cells and together they accomplish...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Research tool, Vector/Plasmid
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Genetic Control of Mammalian Circadian Rhythms: Sequence, Function, and Utility of the Clock Gene and its Product
NU 1997-008, NU 1997-050 and NU 1998-033 InventorsJoseph S. Takahashi Fred W. Turek*Lawrence H Pinto AbstractNorthwestern researchers have discovered a gene in mice and humans that regulates both the periodicity and the persistence of circadian rhythms. The circadian clock regulates a daily cycle of physical and chemical processes in all eukaryotes...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Research tool, Vector/Plasmid
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Biomarker for Replicative Senescence
NU 2011-160 InventorsTakeshi ShimiRobert Goldman*Stephen AdamShort DescriptionNovel protein found in intermediate nuclear filaments as a biomarker for replicative senescence AbstractNorthwestern researchers have identified a novel biomarker for replicative senescence, a state where cell division ceases. The novel biomarker, lamin B1 (LB1), is a nuclear...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biomarker, Research tool, Vector/Plasmid
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Luciferase Reporter for Heat Shock Protein Promoter
NU 2009-004 Inventor Richard I. Morimoto Short Description Novel reagent for detection of heat shock protein response Abstract A Northwestern University researcher designed a reporter plasmid for quantitative determination of heat shock protein (HSP) response in a variety of cell lines. HSP response has been implicated as a mechanism of cell protection...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Research tool, Vector/Plasmid
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
Recombinant Protein Production and Purification without Affinity Tags
NU 2008-069 Inventors Karla Satchell Abstract A Northwestern researcher has developed a new method for researchers to produce and purify recombinant proteins with a patented technology that auto-cleaves extraneous sequences leaving the native protein sequence behind. The technology can be easily packaged as a single kit, including the package vector,...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Research reagent, Research tool, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Therapeutics