Search Results - theodore+theodore

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REV-ERBα Modulators for the Treatment of Autoimmune Disorders

Activates the REV-ERBα Nuclear Receptor to Suppress TH17 Cell Development and TH17-Mediated Autoimmune and Chronic Inflammation These small molecules activate the REV-ERBα nuclear receptor to repress TH17 cell activity and treat autoimmune and chronic inflammatory disorders. TH17 cells are a subset of CD4+ T cells that play key roles in...

Published: 3/13/2025 | Inventor(s): Laura Solt, Theodore Kamenecka, Yuanjun He, Brett Bookser, Mike Lizarzaburu

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics

REV-ERBα Modulators for the Treatment of Autoimmune Disorders

Published: 3/13/2025 | Inventor(s): Laura Solt, Theodore Kamenecka, Yuanjun He, Brett Bookser, Mike Lizarzaburu

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics

Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay

Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...

Published: 3/4/2025 | Inventor(s): Yong Zeng, He Yan

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics

Smart Nanoparticle-Based Cellular Transfection Tool for Therapeutic Development

Utilizes Light-Responsive Nanoparticles to Load Exosomes with Cargo Molecules Precisely and Efficiently, Maximizing Their Ability as Therapeutics This smart nanoparticle-based cellular transfection tool utilizes light-responsive nanoparticles to load therapeutic cargo molecules on demand into extracellular vesicles (EVs), or so-called exosomes, for...

Published: 2/26/2025 | Inventor(s): Mei He

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics

Super-sodiophilic seeds for dendrite‑free sodium metal batteries

Background As the demand for renewable energy sources and electric vehicles grows, there is a pressing need for efficient, sustainable, and cost-effective battery technologies. Sodium-metal batteries (SMBs) show great promise for energy storage applications due to the natural abundance and low cost of sodium compared to lithium. However, SMBs...

Published: 2/11/2025 | Inventor(s): Arumugam Manthiram, Jiarui He, Amruth Bhargav

Keywords(s):

Category(s): Physical sciences > Energy > Battery or electrochemical

Use of MRS to Identify Chronic Injury Post-Stroke

This invention involves using magnetic resonance spectroscopy (MRS) to identify lipid-laden foam cells to diagnose a chronic stroke injury. This technology is specifically meant for monitoring patients post-stroke brain injury. This largely relates to improving management patient care and advancing stroke therapeutics. Background: Currently, MRS...

Published: 2/10/2025 | Inventor(s): Helena Morrison, Theodore Trouard

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Diagnostics

Enhanced fluorescence via DNA aptamer optimization

This invention improves the fluorescence of DNA-based aptamers by substituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...

Published: 12/6/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform

Fluorescence lifetime imaging for retinal function assessment

This invention uses a laser-based imaging system to study the eye’s retina. By measuring light responses, it provides insights into retinal health and potential diseases like age-related macular degeneration. Background Two-photon excited fluorescence (TPEF) is a powerful technique used to study the eye. TPEF allows researchers to excite intrinsic...

Published: 10/24/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Trung Nguyen, Yuan-I Chen, H. Grady Rylander, Yu-An Kuo, Soonwoo Hong, Anh-Thu Nguyen, Yujie He

Keywords(s):

Category(s): Life sciences > Imaging, Life sciences > Imaging > Microscopy

Enhanced VR Battery Life through Perception-Guided Color Encoding

Innovative VR display power reduction using color perception technology, which enhances battery life without sacrificing visual quality Institute Reference: 1-24019 Background The rapid advancement of Virtual Reality (VR) and Augmented Reality (AR) technologies has resulted in a growing demand for higher resolution, faster refresh rates, and improved...

Published: 10/22/2024 | Inventor(s): Yuhao Zhu, Abhishek Tyagi, Jiayi He, Budmonde Duinkharjav, Kenneth Chen, Qi Sun, Nisarg Ujjainkar

Keywords(s):

Category(s): Optics, Computer Software, Devices

Affinity measurement and sequencing of T cell receptor

The technology enables the measurement of T cell receptor (TCR) affinity and sequencing of antigen-specific T cells using a micropipette adhesion assay and single-cell paired TCRα/TCRβ sequencing. The method isolates antigen-specific T cells, measures TCR affinity, and determines TCR sequences for applications in immunotherapy and monitoring...

Published: 9/13/2024 | Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Keyue Ma, Chenfeng He

Keywords(s):

Category(s): Life sciences > Immunology, Life sciences > Research tools > Tool/assay/screening platform

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