Search Results - yuanjun+he

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Self-Powered Electrical Stimulation Magnetoelastic Bandage for Accelerated Wound Healing (Case No. 2025-99N)
Reference: UCLA Case No. 2025-99N Please reach out to our office for more information.
Published: 9/12/2025   |   Inventor(s): Jun Chen, Kanishk Rai, Song Li, Il Woo Ock, Haochen Nan
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Aesthetic Medicine, Materials, Materials > Functional Materials, Materials > Membranes, Electrical, Electrical > Flexible Electronics
A Smart Pen for Parkinson’s Disease Diagnostics (Case No. 2025-283)
Summary UCLA researchers have developed a smart pen for Parkinson’s Disease (PD) diagnostics that converts handwriting motions—both on paper and in air—into high-fidelity voltage signals for accurate, accessible, and low-cost disease screening. This pen leverages magnetoelastic sensing and ferrofluid ink to enable self-powered, quantitative...
Published: 9/12/2025   |   Inventor(s): Jun Chen, Guorui Chen
Keywords(s):  
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Hospital Systems, Diagnostic Markers, Diagnostic Markers > Aging
TDP-43 In Vivo Mouse Model
This is an in vivo mouse model of TDP-43 proteinopathy that captures key features of human neurodegenerative disease, particularly Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). The model targets a disease-relevant disruption in TDP-43’s interaction with cytoplasmic translational machinery, causing a cascade...
Published: 9/2/2025   |   Inventor(s): Xinglong Wang, Ju Gao
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Research Tools > Animal Models
SPLICER: Small Molecule-Inducible Gene Expression Switches
Enables Ligand-Inducible Regulation of Gene Expression or Knockdown This small molecule-inducible gene expression based on riboswitches (SPLICER) enables precise, drug-responsive control of gene expression for safer and more flexible gene and cell therapies. In mammalian cells, alternative splicing greatly expands the diversity of RNA sequences. These...
Published: 9/2/2025   |   Inventor(s): Eric Wang, Yu Zhou
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
Fluorescence Polarization Probe for identifying inhibitors of Enterovirus D68 2C
​ Design of the 2C fluorescence polarization probe Jun14157 and assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis (AFM), where...
Published: 8/20/2025   |   Inventor(s): Jun Wang, Kan Li
Keywords(s):  
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
“Y”-shaped symmetric Enterovirus D68 2C inhibitors are antiviral drug candidates
​ Graphical abstract describing design of “Y”-shaped symmetric 2C inhibitors. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis...
Published: 8/20/2025   |   Inventor(s): Jun Wang, Hiwot Demssie
Keywords(s):  
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
New SARS-CoV-2 papain-like protease inhibitor compounds are potent antiviral drug candidates
​ Binding site of the target papain-like protease of the SARS-CoV-2 virus targeted by these inhibitors. Figure reproduced from inventors’ related paper in Science describing unrelated compounds (link). Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts...
Published: 8/8/2025   |   Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav
Keywords(s):  
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
Large-Area Solution-Processed Ionomer-Interlayered Bulk Monolayer MOS2 Membranes With Thickness-Scalable Bright Luminescence and Dual Electron-Ion Transport (Case No. 2025-281)
Summary: UCLA researchers have developed a novel hybrid 2D material platform that significantly improves the utility and optical performance of monolayer molybdenum disulfide (MoS2) by integrating a Nafion interlayer. Background: Monolayer transition metal dichalcogenides (TMDs), particularly MoS2, have shown promise in the fields of optics and...
Published: 8/7/2025   |   Inventor(s): Xiangfeng Duan, Yu Huang, Boxuan Zhou
Keywords(s):  
Category(s): Materials, Materials > Functional Materials, Materials > Semiconducting Materials, Materials > Membranes, Materials > Composite Materials, Electrical, Electrical > Flexible Electronics, Electrical > Electronics & Semiconductors, Electrical > Sensors, Chemical, Chemical > Chemical Sensors, Chemical > Polymers
Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. ​ Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates
​ Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Ahmadullah Ansari, Francesc Ruiz Figueras, Edward Arnold
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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