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Search Results - mei+he
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Exosome Gene Therapy for Treating Inner Ear Disease
Extracellular Vesicles Directly Target Inner Ear Cells to Correct Malfunctioning Genes In Vivo This in vivo gene therapy strategy combines selective gene editors with the cell targeting capability using extracellular vesicles for safe and targeted delivery., Hearing loss affects at least 1 in 500 newborns, and over 50% are hereditary in nature. One...
Published: 9/3/2024
|
Inventor(s):
Mei He
,
Xiaoshu Pan
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Gene Therapy
,
Technology Classifications > Human Health Care > Drug Delivery
Droplet-Based Electroporation for High-Throughput Biomolecular Cargo Loading of Extracellular Vesicles and Exosomes
Optimizes Cargo Loading a Sub-Cellular Scale, Enabling the Scaling of Drug Manufacturing This electroporation platform enables the efficient, large-scale loading of biomolecular cargo into extracellular vesicles (EVs) and exosomes. Extracellular vesicles (EVs) are biocompatible, have fast cellular uptake, and can penetrate biological barriers, making...
Published: 4/1/2024
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Inventor(s):
Mei He
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Therapeutics
,
Technology Classifications > Human Health Care > Drug Delivery
Genomics-based Diagnostic Assay for Cancer
Abstract: Molecular profiling with high throughput assays has gained utility in the management of select cancer patients and several gene expression-based assays are now marketed for improved prognostic accuracy for patients with cancer. This technology describes a genomics based diagnostic assay for the diagnosis and prognosis of cancer patients. ...
Published: 4/8/2024
|
Inventor(s):
Steven Libutti
,
Mei He
Keywords(s):
assay
,
CANCER
,
diagnostic
,
Genomics
,
PROGNOSIS
Category(s):
Application > Diagnostics
,
TherapeuticArea > Oncology
,
Collaboration Sought > Licensing
Efficient and Scalable Cellular Production of Immune Functional Extracellular Vesicles
Utilizes Low-Power, Near-UV Light Induction to Produce Dendritic Cell-Derived Extracellular Vesicles for Use in Immunotherapy This simple, straightforward, and scalable production of dendritic cell-derived extracellular vesicles (DC-EVs) employs low-power, near-UV light. Dendritic cells are the most potent antigen-presenting cells and the key initiator...
Published: 7/24/2023
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Inventor(s):
Mei He
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Drug Delivery
Recombinant Modified Bacillus anthracis Protective Antigen for Use in Vaccines
This invention relates to improved methods of preparing Bacillus anthracis protective antigen (PA) for use in vaccines. PA is a secreted, non-toxic protein with a molecular weight of 83 KDa. PA is a major component of the currently licensed human vaccine (Anthrax Vaccine Adsorbed, AVA). Although the licensed human vaccine has been shown to be effective...
Published: 12/31/2024
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Inventor(s):
John Robbins
,
Stephen Leppla
,
Rachel Schneerson
,
M Rosovitz
Keywords(s):
Anthrax
,
ANTIGEN
,
Chromosome 18 ring
,
Chymotrypsin-Sensitive
,
CREATION
,
Cutaneous anthrax
,
DAXXXX
,
DBXXXX
,
DC4XXX
,
DC6XXX
,
DCXXXX
,
DDXXXX
,
DELETIONS
,
DXXXXX
,
Furin-Cleavage...
,
Loop
,
MOLECULE
,
Protective
,
R 18
,
recombinant
,
rPA
,
STABLE
,
UAXXXX
Category(s):
Application > Diagnostics
,
TherapeuticArea > Rare / Neglected Diseases
,
Application > Research Materials
,
TherapeuticArea > Infectious Disease
,
Application > Therapeutics
,
Application > Vaccines
Cost-Effective Single-Step Process for the Catalytic Conversion of Methane to Methanol/Formaldehyde
Unmet Need: Currently there is no technology available in the market capable of producing Dimethyl Ether (DME) from methane in a single reactor. DME is an attractive substitute for diesel due to its high cetane number, which is a measure of its ignitibility in compression ignition engines. In addition, DME’s quiet combustion and inability to form...
Published: 10/8/2024
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Inventor(s):
Su Ha
,
M Norton
,
Oscar Marin Flores
Keywords(s):
Category(s):
Technologies > Health & Well-being > Chemistry
,
Technologies > Energy & Environment > Energy
Pharmacological EZH2 inhibition enhances cancer cell sensitivity to genotoxic insults through suppressing DNA damage repair
HSC-1535 Pharmacological EZH2 inhibition enhances cancer cell sensitivity to genotoxic insults through suppressing DNA damage repairKexin Xu: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.Myles Brown: Center for Functional Cancer Epigenetics and Department of Medical Oncology,...
Published: 5/28/2024
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Inventor(s):
Kexin Xu
,
Myles Brown
,
Chen-Hao Chen
,
Xiaole Shirley Liu
,
CPRIT
Keywords(s):
Category(s):
Clinical Specialty > Oncology
,
Clinical Specialty > Radiology
,
Diagnostics > Assay
,
Life Sciences Research Tools > Biomarkers
Voltage-Responsive Coating for Lithium-Sulfur Battery
UC Case No. 2013-764SUMMARYResearchers in the UCLA Department of Chemical and Biomolecular Engineering have developed a lithium-sulfur battery that overcomes the poor recharging and short lifespan problems common among other lithium-sulfur battery configurations. BACKGROUNDLithium ion batteries are widely used in applications ranging from portable...
Published: 7/19/2023
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Inventor(s):
Yunfeng Lu
,
Zheng Chen
,
Qiangfeng Xiao
,
Huihui Zhou
,
Xiaolei Wang
,
Mei Cai
Keywords(s):
Energy & Water
,
Energy Generation & Storage
Category(s):
Energy & Environment > Energy Storage > Batteries
Low-Power Edge Device for Wireless Communication Range Extension
An enhanced, ultra low power passive wake-up radio-based sensor includes a passive wake-up radio-based sensor node having an energy harvester and low power wake-up circuit to improve the wake-up range for passive wake-up radio sensor nodes without the need for local power. The wake-up sensor may additionally include a transmitter for providing a wake-up...
Published: 5/7/2024
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Inventor(s):
Wendi Heinzelman
,
He Ba
,
Li Chen
Keywords(s):
Category(s):
Communications
2011-800 MAKING NANOSTRUCTURED POROUS HOLLOW SPHERES WITH TUNABLE STRUCTURE
Making Nanostructured Porous Hollow Spheres with Tunable StructureSUMMARYUCLA researchers in the Department of Chemical Engineering have developed a novel method of preparing inorganic nanospheres with porous hollow interiors.BACKGROUNDFuel cells are a promising alternative to combustion and are one of the cleanest and most efficient technologies for...
Published: 7/19/2023
|
Inventor(s):
Yunfeng Lu
,
Hiesang Sohn
,
Qiangfeng Xiao
,
Mei Cai
Keywords(s):
Catalysts
,
Chemical Manufacturing & Industrial/Bulk Chemicals
,
Energy & Water
Category(s):
Chemical > Synthesis
,
Energy & Environment > Energy Storage > Batteries
,
Energy & Environment > Energy Storage > Fuel Cells
,
Chemical > Industrial & Bulk Chemicals
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