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This invention uses membrane vesicles from bacteria to deplete oxygen in the gut, preventing the growth of harmful bacteria and improving colon health, particularly in conditions like colitis. https://nu.technologypublisher.com/files/sites/thumbnail_(1).jpeg Background A healthy gut is anaerobic. This anaerobic state is maintained through a...

Published: 9/10/2024 | Inventor(s): Kim Lewis, Norman Pitt, Madeleine Morrissette

Keywords(s): Healthcare Innovation, Microbiology

Category(s): -Health, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Therapeutics

Neuro-Behavioral Assay for Physiological Evaluation of Water-Soluble Anesthetics

Background The development and use of general anesthetics is a key aspect of modern medicine. However, the current reliance on lipid-soluble general anesthetics presents issues, particularly for elderly patients who often have increased adipose tissue and decreased body water. This demographic can respond poorly to lipid-soluble anesthetics, resulting...

Published: 9/10/2024 | Inventor(s): Gunther Zupanc, David Lehotzky

Keywords(s): Anesthesiology, Assays, Chemotherapy, Drug Discovery & Development, High Throughput Screening

Category(s): Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Drug Discovery

Single-cell Pairing Chip for Personalized Immunotherapeutic Screening

INV-19067 Background Natural Killer cells are a type of white blood cell that physically interact with target cancer cells and determine whether to lyse them. The innate heterogeneity of both cancer and NK cells leads to a variety of interactions between pairs of NK-cancer cells. Therefore, single-cell analysis would help in analyzing these interactions...

Published: 9/10/2024 | Inventor(s): Yantao Fan, Tania Konry

Keywords(s): Biotech, Cancer

Category(s): -Biology, -Devices, -Cancer, Technology Classifications > 1. Life Science, Diagnostics, Chemistry, Technology Classifications > 1. Life Science > Drug Discovery

Transwell Millifluidic

INV-19073 Background Many common microfluidic devices experience issues with cell seeding due to their small dimensions and need to be seeded using perfusion. Similarly, the diffusion of nutrients, including oxygen, is limited in many common microfluidics also due to small dimensions. Additionally, while immunofluorescence is the main analytical assay...

Published: 9/10/2024 | Inventor(s): Eno Ebong, Ian Harding, Ira Herman, Abigail Koppes, Alex Caraballo

Keywords(s): Biotech, Cardiovascular, Devices

Category(s): Technology Classifications > 2. Physical Science, Technology Classifications > 2. Physical Science > Lab tech/equipment, Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Drug Discovery

Consistent and enhanced production of anti-cancer drugs from the Madagascar periwinkle plant

INV-19070 Background The Madagascar periwinkle plant has been used for vinblastine (VBL) and vincristine (VCR) since the 1960s. These chemical compounds have been listed on “World Health Organization’s Model List of Essential Medicines”. However, due to high cost, low concentration in extracts, and unpredictable supply, the applications...

Published: 9/10/2024 | Inventor(s): Carolyn Lee-Parsons, Elisa Peter, Samuel Mortensen

Keywords(s): Agriculture/Horticulture, Chemotherapy, Manufacturing, Process, Renewable

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Chemistry, Technology Classifications > 1. Life Science > Green Chemistry, Technology Classifications > 1. Life Science > Drug Discovery

A Parallel Droplet Microfluidic Device for Monitoring of Bacteria Culture and Multi-drug Screening

INV-17084 Background To combat antibiotic-resistant bacterial infections there is a need for rapid discovery of new antibiotic drugs. Traditionally antibiotic testing is performed by methods such as an antimicrobial susceptibility test (AST) that requires longer analysis time. New techniques such as MALDI-TOF mass spectroscopy and nucleic acid amplification...

Published: 9/10/2024 | Inventor(s): Wenjing Kang, Tania Konry

Keywords(s):

Category(s): -Devices, Technology Classifications > 2. Physical Science > Lab tech/equipment, Antimicrobial, Technology Classifications > 1. Life Science > Drug Discovery

New Method for Discovery of Bioactive Molecules

INV-20024 Background Microbes are a foundation of the discovery of bioactive molecules because they produce an enormous variety of secondary metabolites, some with desirable activities ranging from antibiotics to anti-inflammatory to anticancer to industrial enzymes. The advent of next-generation sequencing technologies uncovered that microbial genomes...

Published: 9/10/2024 | Inventor(s): Slava Epstein

Keywords(s): Antimicrobial, Biomolecules, Cancer, Drugs, Microbiology

Category(s): -Method, Antimicrobial, Technology Classifications > 1. Life Science > Gene sequencing, Technology Classifications > 1. Life Science > Drug Discovery

Rapid, benchtop, manufacturing of microfluidic organs-on-chips with integrated electrodes using laser cut double sided adhesives, thermoplastics and inkjet printed silver electrodes

INV-18019 Background In recent years, there has been an increased interest in organs-on-chips technology as these physiological models may augment drug discovery. However, the lack of rapid, scalable, and facile manufacturing techniques limit the widespread use of organs-on-chips. Most intestine-on-a-chip models are manufactured via poly(dimethylsiloxane)...

Published: 9/10/2024 | Inventor(s): Abigail Koppes, Sanjin Hosic, Shashi Murthy, Ryan Koppes, Jonathan Soucy

Keywords(s):

Category(s): Technology Classifications > 2. Physical Science > Manufacturing, Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Drug Discovery

Allosteric Modulators of CB1 Cannabinoid Receptors

style-name: Hyperlink;color: #0000FF;text-decoration: underline; } INV-1242 Background Anorexia nervosa (AN) is a major psychiatric eating disorder associated with substantial morbidity and mortality. Its characteristic symptoms include the refusal to maintain minimally normal body weight, an intense fear of becoming fat, and a disturbed perception...

Published: 9/10/2024 | Inventor(s): Ganeshsingh Thakur, Pushkar Kulkarni

Keywords(s): Cancer, Chemistry, Drug Discovery & Development, Drugs, Therapeutic

Category(s): -Chemistry, -Pharmaceutical Composition, -Health, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Discovery

Allosteric Probes for CB1 Cannabinoid Receptor

esponse. The enhancers of CB1 receptor activity have the potential to treat diseases such as depression, anxiety, multiple sclerosis, and pain. CB1 inhibitors can treat metabolic syndrome as well as drug and alcohol addiction. CB1 inhibitor drugs have been developed for the treatment of type 2 diabetes, weight loss, smoking cessation, and osteoporosis...

Published: 9/10/2024 | Inventor(s): Ganeshsingh Thakur, Pushkar Kulkarni, Abhijit Kulkarni, Ritesh Tichkule

Keywords(s): Chemistry, Drug Discovery & Development, Health, Pharmaceutical Composition

Category(s): -Pharmaceutical Composition, -Health, -Chemistry, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Discovery

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