Search Results - meni+wanunu

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Nanopore and membrane protein dynamic multichannel measurement apparatus and fabrication method for same
INV-23089 Background: Nanopore sensing devices are integral to scientific research and applications such as DNA sequencing and protein detection. The dynamic of trans and cis user access to a membrane in such devices can, however, pose significant challenges. Fulfilling the need for multiplexed and scalable nanopore sensing systems, especially those...
Published: 10/15/2024   |   Inventor(s): Meni Wanunu, Ali Fallahi, Amr Makhamreh
Keywords(s): Biosensing, Drug Discovery, Microfluidics, Nanopores, Protein sequencing
Category(s): Technology Classifications > 2. Physical Science, Technology Classifications > 1. Life Science > Gene sequencing, Technology Classifications > 1. Life Science, Diagnostics
Linearization and Translocation of Single Protein Molecules Through Biological Nanopores
INV-21060 Background Nanopore sensing is a promising technology that detects and sequences biomacromolecules without depending on biomolecule modification, labeling, or surface immobilization. Rapid detection of biomacromolecules revolutionizes the field of proteomics and disease diagnosis. Nanopore technology employs nanoscale pores between two electrolytic...
Published: 10/15/2024   |   Inventor(s): Meni Wanunu, Luning Yu, Aleksei Aksimentiev, Behzad Mehrafrooz
Keywords(s): Protein sequencing
Category(s): -Biomedical Materials, -Nanotechnology, -Materials, Technology Classifications > 1. Life Science
A Nanopore Device to Discretely Measure Viral Particle Count and Functional Titer with Single-molecule Resolution
INV-21063 Background An effective response to viral infections relies on rapid, selective, and sensitive detection of viruses. However, it is so difficult to quantify the concentration of packaged viruses in a sample that researchers use indirect metrics to assess concentration such as plaque-forming units (PFU). Other methods for viral analysis such...
Published: 9/10/2024   |   Inventor(s): Sara Rouhanifard, Meni Wanunu
Keywords(s): virus
Category(s): -Biomedical Materials, -Nanotechnology, Technology Classifications > 1. Life Science
photochemical etching of silicon nitride surfaces and freestanding membranes
INV-18084 Background Silicon nitride is a widely used material as a component in solid-state devices for many applications such as biotechnology, electronics, photonics, and other areas. Processing silicon nitride films in order to provide defined topographical features is a major part of the silicon industry, and it has been a routine practice...
Published: 10/15/2024   |   Inventor(s): Meni Wanunu, Hirohito Yamazaki
Keywords(s):  
Category(s): -Materials, Technology Classifications > 2. Physical Science > Electronics/Semiconductors
Pinhole Zero-Mode Waveguides
INV-15100 Background Zero-mode waveguides (ZMWs) are nanostructures that can be used to isolate and optically investigate single molecules using fluorescence measurements. ZMWs suffer from inefficiency problems with sample loading as they rely purely on diffusion for the localization of molecules in the ZMW detection volume. Several methods have...
Published: 9/10/2024   |   Inventor(s): Meni Wanunu, Joseph Larkin, Robert Henley
Keywords(s):  
Category(s): -Optics, -Materials
Porous Transition Metal Dichalcogenides Nanosheets and Quantum Dots Fabrication Thereof
INV-18002 Background The increasing global need for potable water is critical. While water is available in ample quantities on earth, the vast majority (>98%) is in undrinkable form (e.g., seawater, brackish water, or sewage water). There is a need for new materials and processes that can efficiently purify water by removing debris, biological...
Published: 9/10/2024   |   Inventor(s): Meni Wanunu, Bedanga Sapkota
Keywords(s):  
Category(s): -Materials, -Nanotechnology, Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials
Contactless Optothermal Heating of Silicon Nitride for Instant Temperature Control of Individual Particles, Molecules, and Molecular Complexes near Surfaces
INV-17039 Background A nanopore is a nanoscale hole through a solid-state impermeable membrane that separates two electrolyte buffer reservoirs. The nanopore is filled with the same electrolyte buffer, which makes a liquid junction between the two reservoirs. The temperature at the nanopore is measured by tracking the ion current through the pore,...
Published: 10/15/2024   |   Inventor(s): Meni Wanunu, Hirohito Yamazaki
Keywords(s):  
Category(s): -Microbiology
Electrically Actuatable Zero-mode Waveguides for High-Throughput pg-Level Sequencing
INV-20008 Background DNA sequencing technologies have undergone tremendous improvements in recent years in throughput and quality. One advantage of single-molecule DNA sequencing technologies is that long DNA molecules can be read in a single run, which greatly facilitates genome assembly and aids in the construction of reference-quality genomes....
Published: 9/10/2024   |   Inventor(s): Meni Wanunu, Mohammadamin Alibakhshi, Fatemeh Farhangdoust
Keywords(s): DNA sequencing, single-molecule
Category(s): Technology Classifications > 1. Life Science > Gene sequencing, Technology Classifications > 1. Life Science, Chemistry, Technology Classifications > 1. Life Science > Biotechnology
High-Resolution Sensor of Biopolymer Sequence and Molecules Based on a Localized Nanopore Electrode Sequencer (LNES)
INV-19043 Background This technology introduces two approaches to polymer sequencing using nanopores in electrically conducting, ion‐intercalating MXene membranes, split into two applications: - The first application of MXene membranes is based on ion transport localization between an ultrathin nanopore composed of intercalated ions (between MXene...
Published: 10/15/2024   |   Inventor(s): Meni Wanunu, Mehrnaz Mojtabavi, Armin Vahid Mohammadi, Majid Beidaghi
Keywords(s): DNA sequencing, Nanopores, Protein sequencing, RNA sequencing, Single-molecule mapping
Category(s): Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering
Lipid-Free Anchoring of Thermophilic Bacteriophage G20C Portal Adapter into Solid-State Nanopores
INV-18089 Lipid-free Anchoring of Thermophilic Bacteriophage G20C Portal Adapter into Solid-State Nanopores A novel system for high‑resolution DNA and RNA sequencing, protein identification, and protein conformational change monitoring Background Nanopore-based sensors have advanced the sensitivity and selectivity of single-molecule detection....
Published: 10/15/2024   |   Inventor(s): Meni Wanunu, Alfred Antson, Sandra Greive, Benjamin Cressiot
Keywords(s):  
Category(s): -Biology, Technology Classifications > 1. Life Science > Biotechnology
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