Search Results - ganeshsingh+thakur

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Allosteric Modulators of CB1 Cannabinoid Receptors
style-name: Hyperlink;color: #0000FF;text-decoration: underline; } INV-1242 Background Anorexia nervosa (AN) is a major psychiatric eating disorder associated with substantial morbidity and mortality. Its characteristic symptoms include the refusal to maintain minimally normal body weight, an intense fear of becoming fat, and a disturbed perception...
Published: 9/10/2024   |   Inventor(s): Ganeshsingh Thakur, Pushkar Kulkarni
Keywords(s): Cancer, Chemistry, Drug Discovery & Development, Drugs, Therapeutic
Category(s): -Chemistry, -Pharmaceutical Composition, -Health, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Discovery
Allosteric Probes for CB1 Cannabinoid Receptor
esponse. The enhancers of CB1 receptor activity have the potential to treat diseases such as depression, anxiety, multiple sclerosis, and pain. CB1 inhibitors can treat metabolic syndrome as well as drug and alcohol addiction. CB1 inhibitor drugs have been developed for the treatment of type 2 diabetes, weight loss, smoking cessation, and osteoporosis...
Published: 9/10/2024   |   Inventor(s): Ganeshsingh Thakur, Pushkar Kulkarni, Abhijit Kulkarni, Ritesh Tichkule
Keywords(s): Chemistry, Drug Discovery & Development, Health, Pharmaceutical Composition
Category(s): -Pharmaceutical Composition, -Health, -Chemistry, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Discovery
Novel Allosteric Modulators of CB1 Cannabinoid Receptor
Background A novel class of compounds containing indole functionality has been found to have robust positive allosteric modulator (PAM) activity at the CB1 cannabinoid receptor. GAT1102 is a representative compound from this class shown to be effective in lowering intraocular pressure in the animal model with potential utility in treating glaucoma. ...
Published: 10/15/2024   |   Inventor(s): Ganeshsingh Thakur, Sumanta Garai
Keywords(s):  
Category(s): Technology Classifications > 1. Life Science > Biotechnology
Novel Selective Activators of Neuronal GIRK Heteromeric Channels Effective in Animal Models of Post-Traumatic Stress Disorder
-collapse: collapse; } INV-18111 Background G protein-gated inwardly rectifying potassium (GIRK) channels, are channels distributed throughout the central nervous system as well as the heart. Pharmacological investigations of GIRK channels, along with studies in animal models, suggest that GIRK activity has an important role in physiological...
Published: 9/10/2024   |   Inventor(s): Ganeshsingh Thakur, Diomedes Logothetis, Anantha Shekhar, Yu Xu, Lucas Cantwell
Keywords(s):  
Category(s): Technology Classifications > 1. Life Science > Therapeutics