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Enzymatic amplification/fragmentation approach for quantifying biomarkers using nanopores

A method based on antibodies to electrically detect biomarkers in serum and other samples Background: Biomarkers serve as indicators of biological processes or conditions. The need for advanced technology in this area arises from the demand for early and accurate detection of diseases, which can significantly improve patient outcomes through timely...

Published: 5/26/2026 | Updated: 7/11/2025 | Inventor(s): Meni Wanunu, Xinqi Kang, Mohammadamin Alibakhshi, David Walt, Connie Wu

Keywords(s): Nanopores

Category(s): Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials, Technology Classifications > 1. Life Science > Chemistry, Technology Classifications > 1. Life Science > Diagnostics, Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Gene sequencing, Technology Classifications > 1. Life Science > Medical Devices, Technology Classifications > 2. Physical Science > Sensors/Robotics

Sealable Microvalve That Can Be Repeatedly Opened and Sealed

ink;color: #0000FF;text-decoration: underline; } INV-1243 Background The typical structure for a MEMS microvalve includes an orifice and a moveable plate that can be actuated to press against the orifice. When the plate does not press against the orifice, fluid can flow through the orifice and therefore through the valve. When the plate is pressed...

Published: 8/19/2025 | Updated: 4/3/2024 | Inventor(s): Carol Livermore, Chenye Yang

Keywords(s): Chemistry, Diagnostics, Environment, Homeland Security, Sensor Technology

Category(s): Technology Classifications > 2. Physical Science > Environmental/Clean tech, Technology Classifications > 2. Physical Science > Lab tech/equipment, Not in use > -Sensors tech, Not in use > -Chemistry, Not in use > -Equipment, Not in use > -Homeland Security, Not in use > -Health, Technology Classifications > 1. Life Science > Diagnostics

A wide-field system integrating intensity- and spatially- modulated light for diffuse optical tomography and spectroscopy applications

INV-22102 Background Diffuse optical tomography (DOT) is a non-invasive optical imaging technique that is capable of imaging deep (>1 cm) tissue physiology, such as angiogenesis and metabolism, using only non-ionizing near-infrared light. When modulating the DOT light source intensity at a radio-frequency (RF), a frequency-domain DOT (FD-DOT) can...

Published: 7/16/2026 | Updated: 2/28/2024 | Inventor(s): Qianqian Fang, Miguel Mireles Nunez, Edward Xu

Keywords(s): Cancer, Diffuse Optical Tomography, Spatial Frequency Domain Imaging (SFDI), Speckle Contrast Optical Spectroscopy (SCOS), Speckle Contrast Optical Tomography (SCOT), Wide-field

Category(s): Technology Classifications > 1. Life Science > Diagnostics, Technology Classifications > 3. Computer Science > Imaging, Technology Classifications > 2. Physical Science > Sensors/Robotics

DNA-based method for rapid capture, detection and analysis of viruses on surfaces

A sensitive and rapid alternative to current viral detection methods INV-21083 Background Thousands of deaths are occurring yearly due to various viral infectious diseases, which has resulted in global public health crisis. COVID‑19 has further brought into focus, the critical need for early detection to prevent transmission, apply effective...

Published: 5/26/2026 | Updated: 1/22/2022 | Inventor(s): Sara Rouhanifard

Keywords(s): Bio-imaging, COVID-19, Diagnostic tool, virus

Category(s): Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Diagnostics, Technology Classifications > Life Science

Site-specific Modification of Antibody through a Tranglutaminase-mediated Conjugation of Glutamine While Maintaining the Core Glycan

Site-specific Modification of Antibody through a Transglutaminase-mediated Conjugation of Glutamine While Maintaining the Core Glycan Technical advancement of site-specific antibody engineering creating more homogenous biologics Institute Reference: INV-21035 Background Antibodies are a predominant class of macromolecules with wide-spread...

Published: 5/26/2026 | Updated: 1/10/2022 | Inventor(s): Zhaohui Zhou, Amissi Sadiki

Keywords(s): Antibody conjugates, Endoglycosidase, Glycan remodeling, Glycoengineering, Transglutaminase

Antibody-based Rolling Circle Amplification for COVID-19 Detection by a Colorimetry

INV-21038 Background Viruses are conventionally detected by RT-PCR. This method requires long analysis time, highly trained professionals, and often shows non-specific characteristics. Antigens and antibodies (Ag/Ab) are commonly used for fluorescence immunoassay. However, the fluorescent signal from the individual fluorescent molecule attached...

Published: 5/26/2026 | Updated: 12/15/2020 | Inventor(s): Tania Konry, Ji Won Lim

Keywords(s): Analytical Chemistry, COVID-19, Detection, Diagnostics

Category(s): Technology Classifications > 1. Life Science > Chemistry, Not in use > -Method, Technology Classifications > 1. Life Science > Diagnostics, Technology Classifications > Life Science

Single-cell Pairing Chip for Personalized Immunotherapeutic Screening

INV-19067 Background Natural Killer cells are a type of white blood cell that physically interact with target cancer cells and determine whether to lyse them. The innate heterogeneity of both cancer and NK cells leads to a variety of interactions between pairs of NK-cancer cells. Therefore, single-cell analysis would help in analyzing these interactions...

Published: 1/27/2026 | Updated: 12/15/2020 | Inventor(s): Tania Konry, Yantao Fan

Keywords(s): Biotech, Cancer

Category(s): Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Chemistry, Not in use > -Cancer, Not in use > -Biology, Not in use > -Devices, Technology Classifications > 1. Life Science > Diagnostics, Technology Classifications > Life Science

Cationic Contrast Agents for Computed Tomography Imaging of Tissues

INV-20021 Background Early diagnosis of degenerative joint diseases like osteoarthritis (OA) is critical because it gives a narrow window of time to reverse disease progression. While computed tomography (CT) can diagnose changes in subchondral bone, it is not clinically viable for imaging joint soft tissues like cartilage that exhibit early degenerative...

Published: 5/26/2026 | Updated: 11/23/2020 | Inventor(s): Ambika Bajpayee, Chenzhen Zhang, Armin Vedadghavami, Tengfei He

Keywords(s):

Category(s): Technology Classifications > 3. Computer Science > Imaging, Technology Classifications > 1. Life Science > Diagnostics

High Resolution Full-Body In-Bed Pose Estimation Platform using Multimodal Sensing

INV-21014 Background Although computer vision has been extremely successful in employing deep neural networks for many visual perception applications, its use is still hindered when it comes to practical medical applications. This shortcoming is due to the factors include lack sample data, the cost of data gathering and labeling, patient privacy and...

Published: 5/26/2026 | Updated: 10/26/2020 | Inventor(s): Sarah Ostadabbas, Shuangjun Liu

Keywords(s): computer vision and deep learning, In-bed pose estimation, Sleeping behavior monitoring

Category(s): Technology Classifications > 3. Computer Science > Software, Not in use > -Diagnostic Software, Not in use > -Health, Technology Classifications > 1. Life Science > Diagnostics

FInD (Foraging Interactive D-prime) - A rapid and general method for efficient and sensitive visual function assessment

21015 Background Vision screening in both clinical and basic science is a critical step that quantifies functional deficits in the visual system. In clinical practice, vision screening is essential for disease diagnosis and monitoring; in basic science, it can quantify sensory or perceptual performance or ensure that research participants meet specific...

Published: 4/24/2026 | Updated: 10/20/2020 | Inventor(s): Peter Bex, Jan Skerswetat

Keywords(s): Adaptive, autism, Detection, Devices, Display, Drug Discovery & Development, Health, Medical, Medical Device, Medical/Health, Mobile devices, Monitoring, Neurological Disease, personalized medicine, Real-Time Implementation, Rehabilitation, Research Tool, Science/Research, Screening Tool, Software and Algorithms

Category(s): Not in use > -Devices, Not in use > -Diagnostic Software, Technology Classifications > 1. Life Science > Diagnostics

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