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Select M. tuberculosis Peptides as Mucosal Vaccines Against Pulmonary Tuberculosis

This CDC-developed technology relates to novel vaccines or boosters directed against pulmonary tuberculosis. There is currently only a single vaccine against tuberculosis, the (Bacillus Calmette-Guérin) BCG vaccine. Reports suggest widely variable effectiveness for the BCG vaccine and that BCG administration has very limited success against prevention...

Published: 7/25/2024 | Inventor(s): Bonnie Plikaytis, Thomas Shinnick, Rama Amara, Mani Cheruvu, Suraj Sable

Keywords(s): Alaine, ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DC1XXX, DC4XXX, DCXXXX, DXXXXX, Identification, Mucosal, MYCOBACTERIUM, OID-NCHHSTP-DTE, PROLINE, Pulmonary, respiratory, Respiratory Diseases, respiratory INFECTION, Rich, TUBERCULOSIS, Vaccine, VACCINE DEVELOPMENT, VJXXXX, VPXXXX, WIXXXX, WJXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, Application > Research Materials, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment

Compositions to Enhance Vaccine Efficacy on Mucosal Surfaces

Targeting moDC to Improve Mucosal Surface ProtectionThis composition targets a subset of dendritic cells that mediate cyclic dinucleotide adjuvant activity, thereby improving mucosal surface protection and response to vaccines. In the 20th century, immunization has allowed us to control several life threatening diseases such as measles, whooping cough,...

Published: 9/3/2021 | Inventor(s):

Keywords(s): Dendritic Cells, mucosal, prevention, Vaccine, vaccine adjuvant

Category(s): Technology Classifications > Human Health Care > Therapeutics