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Novel Antisense Oligonucleotides Targeting RAPTOR Expression to Improve the Pathological Consequences of Genetic Mutations Causing mTORC1 Hyperactivity, including GATOR1 and TSC mutations.
NOVEL RNA INTERFERENCE AGENTS TARGETING mTORC1 ACTIVITY New hope for epilepsy and autism spectrum disorders (ASD) Shutterstock : 2203572829 UNMET NEED Epilepsy and Autism Spectrum Disosrder (ASD) are significant public health concerns, affecting over 65 million people worldwide for epilepsy and 1 in 100 children worldwide (1 in 36 children...
Published: 6/19/2025   |   Inventor(s): Antoine Desmeules, Paul Dutchak
Keywords(s): Innovation
Category(s): Objectifs de Développement Durable > ODD 03 : Bonne santé et bien-être, Sustainable Development Goals > Goal 03: Good Health and Well-Being, Secteurs > Sciences de la vie, Sectors > Life sciences, Applications > Soins et santé > Traitement > Pharmaceutique > Neurologie, Applications > Soins et santé > Traitement > Pharmaceutique > Système nerveux central, English Applications > Health and care > Treatment > Pharmaceuticals > Neurology, English Applications > Health and care > Treatment > Pharmaceuticals > Central nervous system
Confederated C Prime Agents vs Cancers (PDAC) & Metabolic Disorders
Project ID: D2020-28 Background Based upon the success of a mixture of simvastatin (SIM) + metformin (Met) + digoxin (Dig), dubbed “C3”, for treating pancreatic ductal adenocarcinoma (PDAC) via a pleiotropic mechanism where attenuation of the BIRC5 pathway is a major component, we have pursued novel, single-molecular constructs that combine...
Published: 6/4/2025   |   Inventor(s): Paul Erhardt, Shi-He Liu, F. Charles Brunicardi, Divya Andy
Keywords(s):  
Category(s): Oncology
Combining Aminoglycoside Antibiotics and PKZ18 Analogs
Significantly enhances the efficacy of aminoglycosides drugs while reducing the risk of microbial drug resistance. Background: To increase drug efficacy and reduce the risk of the development of resistance to treatment, clinicians often prescribe multiple drugs of different classes in combination. For example, many topical creams use an aminoglycoside...
Published: 5/13/2025   |   Inventor(s): Ville Väre, Kathleen McDonough, Ryan Schneider, Paul Agris, Thorsten Seyler
Keywords(s): antibiotics, antimicrobial, drug development, Staphylococcus aureus, synergistic interaction, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
Computer Program for Determining and Visually Indicating Demyelinated Pathways
A program to display, in pictorial form, an anatomical diagram indicating the demyelinated nerve pathways. Background: In order to determine the amount of nerve damage in cases of acute and chronic demyelinating peripheral neuropathies, patients are subjected to nerve conduction studies which involve nerve responses to electrical stimulation between...
Published: 5/13/2025   |   Inventor(s): Paul Maccabee, Lawrence Eberle
Keywords(s): TAF, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Computers
Encapsulation of Fire-Resistant Materials in Adhesive Polymeric Carriers for Fire Prevention (Case No. 2025-240)
Summary: UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel system for integrating fire-retardant compounds within an adhesive and sprayable material. Background: Fire management traditionally relies on the use of synthetic materials containing ammonium polyphosphate (APP), which are effective in fire suppression...
Published: 6/13/2025   |   Inventor(s): Paul Weiss, Erika Lopez Lara
Keywords(s): antimicrobial materials, Composite Materials, Construction Materials, fire, fire resistant materials, fire resistant materials and nanotechnology, fire retardant, fire tech nanomaterials, Functional Materials, intercalated materials, Materials, Medical Devices and Materials, meta materials, microarchitectured materials, Nanomaterials, nanostructured materials, palisades, phase change materials, photothermal materials, safe materials, wildfire, wildfire prevention
Category(s): Materials, Materials > Fabrication Technologies, Materials > Functional Materials, Energy & Environment
Efficient One-Step Chemical Conversion of MXene Into Quantum Dots (Case No. 2025-246)
Summary: UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel one-step method for producing MXene quantum dots with precise size control in an environmentally safe manner. Background: Quantum dots are widely used in bioimaging due to their tunable optical, electrical, and chemical properties. However, traditional...
Published: 6/10/2025   |   Inventor(s): Paul Weiss, Haiyue Huang, Judy Cheng
Keywords(s): Biochemistry, bioimaging, Biomaterial, Catalysts, Chemical, Chemical Manufacturing & Industrial/Bulk Chemicals, energy conversion, energy conversion applications, Functional Materials, labeling, material science, Materials, Nanomaterials, photoluminescence, Quantum Dot
Category(s): Chemical, Chemical > Synthesis, Materials, Materials > Semiconducting Materials
Analogs of peroxisome proliferator activiated receptor (PPAR) agonists, and methods of using the same
Novel PPARδ Agonists for Bone Growth Background Osteoporosis is a silent disease of bones that affects tens of millions of people over the age of 50 with direct medical costs of over $31 billion yearly due to injuries from falls. With the aging population of the US there is a serious need for effective treatments to combat bone...
Published: 3/27/2025   |   Inventor(s): Bruce Heck, Paul Erhardt, Brian Kress, DongHyun Kim
Keywords(s):  
Category(s): Long Bone/Joint Repair, Oncology
System for Synergistic Air Detoxification and Food Production
Background Food and water shortages are leading to the development of new technologies aimed at sourcing these resources from the air. Atmospheric water harvesting is an emerging field where atmospheric moisture, such as fog and clouds, is collected to obtain liquid water from the atmosphere (in addition to traditional rainwater harvesting). Recent...
Published: 3/4/2025   |   Inventor(s): Pierre Herckes, Paul Westerhoff, Ferran Garcia-Pichel
Keywords(s):  
Category(s): Physical Science, Applied Technologies, Environmental
Material for Enhanced Photoprotection (Case No. 2025-050)
Summary: UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel material for enhanced photoprotection in sunscreens. Background: Exposure to ultraviolet (UV) radiation from the sun contributes to premature skin aging, sunburn, and increased risk of skin cancer. Traditional UV filters such as zinc oxide and titanium...
Published: 4/30/2025   |   Inventor(s): Paul Weiss, Ajoa Addae, Yogendra Mishra
Keywords(s): antimicrobial, antiviral, caprylic/capric triglyceride, cosmetic ingredients, dispersion stability, emulsions, flame transport synthesis, Material for Enhanced Photoprotection, Nanocrystal, nanocrystalline metals, nanodispersion, Photodetector, photostability, photostability materials, photothermal materials, skin protection, sunscreen, sunscreen formulation, tocopheryl acetate, UV absorption
Category(s): Materials, Materials > Functional Materials, Therapeutics, Therapeutics > Dermatology
Liquid Bath Air Filter Respirator
“The Bubbler” Uses Laminar Airflow Dynamics to Efficiently Filter Air This liquid bath air filter efficiently filters air using laminar airflow dynamics. Effective air filtration is crucial, especially for respiratory health. According to the World Health Organization, air pollution contributes to millions of deaths annually. While HEPA...
Published: 3/28/2025   |   Inventor(s): Paul Dominguez-Gutierrez, Tania Quesada
Keywords(s):  
Category(s): Technology Classifications > Medical Devices > Equipment, Technology Classifications > Others > Cleantech
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