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Unified Model of Alzheimer’s Disease Pathobiology

Invention Description Understanding of the pathobiology of Alzheimer’s disease (AD) has long been fragmented, with much research centered around biological mechanisms including amyloid β or tau proteins, inflammation, cell death pathways, glia, mitochondria and more. While these all deal with real facets in the biology of AD, they are limited...

Published: 10/29/2025 | Inventor(s): Carol Huseby, Elaine Delvaux, Paul Coleman

Keywords(s):

Category(s): Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Neurodegenerative Disease Technologies, Pharmaceuticals

Bioinformatically-Identified Control Elements for Regulated Expression from a Lentiviral Vector to Treat X-Linked Lymphoproliferative Disease (UCLA Case No. 2022-065)

UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics and Pediatrics have used a bioinformatics-guided approach to design regulated lentiviral vectors for the treatment of X-linked lymphoproliferative disease type 1. BACKGROUND: X-linked lymphoproliferative disease type 1 (XLP1) is a rare primary immunodeficiency...

Published: 10/17/2025 | Inventor(s): Donald Kohn, Paul Ayoub

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine

Offline Eye Gaze-Based Visual Field Testing System

This technology introduces a portable and affordable way to perform visual field assessment using only a standard webcam and machine learning software. Unlike conventional systems that rely on costly specialized equipment and require constant supervision, this approach tracks eye movements in response to simple on-screen visual stimuli. The software...

Published: 9/15/2025 | Inventor(s): Eung Joo Lee, Paul Chong

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Ophthalmology, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Software & Information Technology > Health IT

POLQ as a Mediator of Radioresistance in Prostate Cancer (UCLA Case No. 2024-068)

Please contact UCLA Technology Development Group for more information. KEYWORDS: cancer biology, cancer therapy resistance, molecular oncology, drug discovery, radiosensitization, radioresistance mechanisms, predictive biomarkers, prostate cancer

Published: 11/3/2025 | Inventor(s): Paul Boutros

Keywords(s):

Category(s): Therapeutics > Oncology, Diagnostic Markers

High-Performance Liquid-Cooled Cold Plates for Targeted Hotspot Management in Multi-Chip Systems

This invention introduces advanced liquid-cooled cold plates with localized micro-channel, pin fin, and lattice structures that deliver targeted hotspot cooling, quasi-uniform temperatures, and reduced pumping power for multi-chip modules and 3D-ICs. Background: High-performance computing systems, AI accelerators, and data centers face thermal management...

Published: 9/24/2025 | Inventor(s): Yaser Hadad, Mahdi Farahikia, Bahgat Sammakia, Paul Chiarot

Keywords(s): Technologies

Category(s): Campus > Binghamton University

Reliable Liquid Metal Composites for Soft Robotics, Electronics, and Thermal Management

This invention introduces oxide-flake-stabilized liquid metal powders that suppress supercooling, enabling reliable phase transitions for tunable stiffness, thermal management, and adaptive devices. Background: Liquid metal (LM)-based composites are promising for tunable stiffness, shape memory, and thermal management applications in robotics, electronics,...

Published: 9/24/2025 | Inventor(s): Pu Zhang, Jiexian Ma

Keywords(s): CleanTech

Category(s): Campus > Binghamton University, Technology Classifications > Engineering

Enhanced Tumor Reactivity of T Cells Lacking SIT1, LAX1 or TRAT1

Summary: The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is actively seeking potential licensees interested in further developing these inhibitory transmembrane adapter proteins as targets for T-cell immunotherapy for the treatment of cancer, infectious diseases, and autoimmune diseases. Description of Technology: Cellular...

Published: 8/21/2025 | Inventor(s): Paul Love, Avik Dutta

Keywords(s):

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology

Novel Antisense Oligonucleotides Targeting RAPTOR Expression to Improve the Pathological Consequences of Genetic Mutations Causing mTORC1 Hyperactivity, including GATOR1 and TSC mutations.

NOVEL RNA INTERFERENCE AGENTS TARGETING mTORC1 ACTIVITY New hope for epilepsy and autism spectrum disorders (ASD) Shutterstock : 2203572829 UNMET NEED Epilepsy and Autism Spectrum Disosrder (ASD) are significant public health concerns, affecting over 65 million people worldwide for epilepsy and 1 in 100 children worldwide (1 in 36 children...

Published: 9/11/2025 | Inventor(s): Antoine Desmeules, Paul Dutchak

Keywords(s): Innovation

Category(s): Objectifs de Développement Durable > ODD 03 : Bonne santé et bien-être, Sustainable Development Goals > Goal 03: Good Health and Well-Being, Secteurs > Sciences de la vie, Sectors > Life sciences, Applications > Soins et santé > Traitement > Pharmaceutique > Neurologie, Applications > Soins et santé > Traitement > Pharmaceutique > Système nerveux central, English Applications > Health and care > Treatment > Pharmaceuticals > Neurology, English Applications > Health and care > Treatment > Pharmaceuticals > Central nervous system, Sectors > RNA Initiative, Secteurs > Intiative ARN

Confederated C Prime Agents vs Cancers (PDAC) & Metabolic Disorders

Project ID: D2020-28 Background Based upon the success of a mixture of simvastatin (SIM) + metformin (Met) + digoxin (Dig), dubbed “C3”, for treating pancreatic ductal adenocarcinoma (PDAC) via a pleiotropic mechanism where attenuation of the BIRC5 pathway is a major component, we have pursued novel, single-molecular constructs that combine...

Published: 6/4/2025 | Inventor(s): Paul Erhardt, Shi-He Liu, F. Charles Brunicardi, Divya Andy

Keywords(s):

Category(s): Oncology

Combining Aminoglycoside Antibiotics and PKZ18 Analogs

Significantly enhances the efficacy of aminoglycosides drugs while reducing the risk of microbial drug resistance. Background: To increase drug efficacy and reduce the risk of the development of resistance to treatment, clinicians often prescribe multiple drugs of different classes in combination. For example, many topical creams use an aminoglycoside...

Published: 10/24/2025 | Inventor(s): Ville Väre, Kathleen McDonough, Ryan Schneider, Paul Agris, Thorsten Seyler

Keywords(s): antibiotics, antimicrobial, drug development, Staphylococcus aureus, synergistic interaction, Technologies

Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

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