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METHODS AND COMPOSITION FOR TARGETED RECEPTOR-MEDIATED PROGRAMMABLE MACROMOLECULE DELIVERY

METHODS AND COMPOSITION FOR TARGETED RECEPTOR-MEDIATED PROGRAMMABLE MACROMOLECULE DELIVERY Researchers at Stanford have developed a novel method for programmable macromolecule delivery via engineered cells, using trogocytosis. Genome editing technologies have revolutionized the field of personalized medicine. Despite its initial promise, many...

Published: 4/22/2024 | Inventor(s): Lei Qi, Xinyi Chen, Wendy Fantl

Keywords(s): Fusion Protein, Protein Engineering, Trogocytosis

Category(s): Technology Classifications > Biology

Fully Human Antibody Targeting Tumor Necrosis Factor Receptor Type 2 (TNFR2) for Cancer Immunotherapy

Abstract: Tumor necrosis factor receptor type 2 (TNFR2)-expressing regulatory T cells (Tregs), present in the tumor microenvironment, play an important role in tumor immune evasion. TNFR2 plays a crucial role in stimulating the activation and proliferation of Tregs, a major checkpoint of antitumor immune responses. In addition to its expression on Tregs,...

Published: 5/22/2024 | Inventor(s): Joost Oppenheim, Dimiter Dimitrov, De Yang, Xin Chen, Zhongyu Zhu

Keywords(s): ADCC, ANTIBODY, Antibody-dependent Cellular Cytotoxicity, CANCER, Immunotherapy, Oppenheim, TNFR2, Tregs, Tumor Necrosis Factor Receptor Type 2

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Novel Multi-Omics Aging Clock

A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...

Published: 3/12/2024 | Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools

Autonomous Drone for railroad track inspection

Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...

Published: 3/15/2023 | Inventor(s): Yu Qian, Yi Wang, Chen Chen

Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation

Category(s): Engineering and Physical Sciences

Engineered globular endolysin, a highly potent antibacterial enzyme for multidrug resistant Gram-negative bacteria

[Licensing negotiation in progress] [Invitation for Expression of Interest- Deadline 2 July 2021] We are inviting expressions of interest (EoI) for commercializing “Engineered Globular Endolysin, a Highly Potent Antibacterial Enzyme for Multidrug Resistant Gram-Negative Bacteria” technology. The innovation is developed by Professor XIA...

Published: 10/17/2023 | Inventor(s): Jiang XIA, Shui Yee LEUNG, Xi CHEN, Miao LIU

Keywords(s):

Category(s): Biotechnology, Therapeutics

2015-671 Underground Shafts for Hydrogen Storage

SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...

Published: 7/19/2023 | Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove

Keywords(s): Energy & Water

Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage