Search Results - philip+murphy

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Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
Human CC Chemokine Receptor CX3CR1 / CMKBRL1 cDNA
A plasmid encodes human CC chemokine receptor CX3CR1/CMKBRL1 as described in DNA Cell Biol. 1995 Aug;14(8):673-80, and developed in the laboratory of Philip M. Murphy at the National Institute of Allergy and Infectious Diseases.
Published: 10/28/2024   |   Inventor(s): Philip Murphy
Keywords(s): cc, CC-CMKBRL1, cDNA, Chemokine, Human, PLASMID, RECEPTOR, RM, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
CXCR1 - Human IL-8 Receptor cDNA
A plasmid encodes human interleukin-8 (IL-8) receptor CXCR1. IL-8 is a chemo-attractant cytokine that attracts and activates neutrophils in inflammatory regions.
Published: 10/28/2024   |   Inventor(s): Sunil Ahuja, Philip Murphy
Keywords(s): CB3AXX, CC1XXX, cDNA, CXCRI, Hu, Human, IL-8, IL-8A, Listed LPM Ano as of 4/15/2015, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, Subtype, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Application > Research Materials
Human CCR3 cDNA
A plasmid encodes human C-C motif chemokine receptor 3 (CCR3). It may contribute to the accumulation and activation of eosinophil and other inflammatory cells in the allergic airway.
Published: 10/28/2024   |   Inventor(s): Sunil Ahuja, Christophe Combadiere, James Pease, Philip Murphy
Keywords(s): 4, CCR3, CCR3;, cDNA, Cell, DA4AXX, DE4-CCR3, Expressing, Human, Line, Listed LPM Ano as of 4/15/2015, Murine, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, VLXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease
Human CCR2 cDNA
A plasmid encodes human C-C chemokine receptor type 2 (CCR2). CCR2 play important roles in the recruitment of monocytes/macrophages and T cells.
Published: 10/28/2024   |   Inventor(s): Sunil Ahuja, Christophe Combadiere, James Pease, Philip Murphy
Keywords(s): cc, CCR2, cDNA, Cell, Chemokine, Cloning, EOSINOPHIL, Expression, FUNCTIONAL, Human, Including, line., Listed LPM Ano as of 4/15/2015, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Human FPRL1 / FPR2 cDNA
A plasmid encodes human formyl peptide receptor-like 1 (FPRL1/FPR2).
Published: 10/28/2024   |   Inventor(s): Philip Murphy
Keywords(s): cDNA, FPRL1, Human, Listed LPM Ano as of 4/15/2015, NC3XXX, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, VEXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Research Materials
Human fMLP Receptor / FPR cDNA
A plasmid encodes human fMLP receptor. Formyl peptide receptor (FPR, fMLP receptor) is a G protein-coupled receptor and mediates anti-inflammatory reactions in human neutrophils and other tissues.
Published: 10/28/2024   |   Inventor(s): Philip Murphy
Keywords(s): cDNA, FMLP, Human, Listed LPM Ano as of 4/15/2015, NC3XXX, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, VEXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Research Materials
CXCR4 Reduction Leads to Enhancement of Engraftment of Hematopoietic Stem Cells
Methods of enhancing engraftment of donor hematopoietic stem cells (HSCs) by reducing expression or activity of CXCR4 in HSCs is described. HSC are the only cells in the bone marrow that are both pluripotent and long lived. Bone marrow transplantation (BMT) using HSC is an increasingly common medical therapy for severe hematologic cancers and primary...
Published: 10/28/2024   |   Inventor(s): Philip Murphy, David Mcdermott, Marie Siwiki, Harry Malech, Qian Liu, Jiliang Gao
Keywords(s): Cell, COPY, CXCR4, Durably, ENGRAFTMENT, Enhanced, hematopoietic, ONE, SILENCING, Stem, VCXXXX, VPXXXX, WJXXXX, XEXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease
Mice Genetically Deficient in the Chemoattractant Receptor FPR (formyl peptide receptor)
The present research tool is a knockout mouse model (FPR-/-) that lacks the high affinity N-formylpeptide receptor (FPR), created by targeted gene disruption. N-formylpeptides derive from bacterial and mitochondrial proteins, and bind to specific receptors on mammalian phagocytes. Since binding induces chemotaxis and activation of phagocytes in vitro,...
Published: 10/28/2024   |   Inventor(s): Jiliang Gao, Philip Murphy
Keywords(s): BAXXXX, CHEMOATTRACTANT, DDXXXX, DEFICIENT, DEXXXX, DXXXXX, Formyl, FPR, GENETICALLY, knockout mice, Mice, MXXXXX, Peptide, RECEPTOR, RM, WIXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, Application > Consumer Products, ResearchProducts > Animal Models
Mouse Lacking the Chemokine Receptor CX3CR1
This mouse has been generated by targeted gene disruption. The mouse provides a model to investigate the function of the chemokine receptor CX3CR1, which is a proinflammatory receptor for the leukocyte chemoattractant CX3CL1 (aka fractalkine). As an example, the mouse is in use in the study of atherosclerosis. Further, the mouse may serve as a model...
Published: 10/28/2024   |   Inventor(s): Philip Murphy, Jiliang Gao
Keywords(s): CA1AXX, CA1XXX, CAXXXX, CXXXXX, RXXXXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Oncology
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