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CXCR4 Reduction Leads to Enhancement of Engraftment of Hematopoietic Stem Cells
Methods of enhancing engraftment of donor hematopoietic stem cells (HSCs) by reducing expression or activity of CXCR4 in HSCs is described. HSC are the only cells in the bone marrow that are both pluripotent and long lived. Bone marrow transplantation (BMT) using HSC is an increasingly common medical therapy for severe hematologic cancers and primary...
Published: 10/28/2024
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Inventor(s):
Philip Murphy
,
David Mcdermott
,
Marie Siwiki
,
Harry Malech
,
Qian Liu
,
Jiliang Gao
Keywords(s):
Cell
,
COPY
,
CXCR4
,
Durably
,
ENGRAFTMENT
,
Enhanced
,
hematopoietic
,
ONE
,
SILENCING
,
Stem
,
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,
VPXXXX
,
WJXXXX
,
XEXXXX
,
YAXXXX
,
YBXXXX
,
YCXXXX
Category(s):
Collaboration Sought > Licensing
,
TherapeuticArea > Ophthalmology
,
TherapeuticArea > Cardiology
,
Application > Therapeutics
,
TherapeuticArea > Dental
,
TherapeuticArea > Endocrinology
,
TherapeuticArea > Oncology
,
TherapeuticArea > Infectious Disease