Search Results - cxcr4

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CXCR4 Reduction Leads to Enhancement of Engraftment of Hematopoietic Stem Cells
Methods of enhancing engraftment of donor hematopoietic stem cells (HSCs) by reducing expression or activity of CXCR4 in HSCs is described. HSC are the only cells in the bone marrow that are both pluripotent and long lived. Bone marrow transplantation (BMT) using HSC is an increasingly common medical therapy for severe hematologic cancers and primary...
Published: 10/28/2024   |   Inventor(s): Philip Murphy, David Mcdermott, Marie Siwiki, Harry Malech, Qian Liu, Jiliang Gao
Keywords(s): Cell, COPY, CXCR4, Durably, ENGRAFTMENT, Enhanced, hematopoietic, ONE, SILENCING, Stem, VCXXXX, VPXXXX, WJXXXX, XEXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease
Targeting LASP1, eIF4A1, eIF4B, and CXC4 with Modulators for treating cancer
Project ID: D2019-32 Background: Breast cancer (BC) is a heterogeneous disease and is the second leading cause of death in women among the cancer mortalities. With the new estimates in 2019, 3 out of 10 women will develop BC in her lifetime and 1 in 7 will succumb to BC. Mortality in BC patients is mainly due to metastasis to the lungs, bone, and brain....
Published: 5/9/2024   |   Inventor(s): Dayanidhi Raman, Cory Howard, John Nemunaitis, F. Charles Brunicardi, Shi-He Liu, Amit Tiwari
Keywords(s): Cancer, CXCL12, CXCL8, CXCLB, CXCR4, eIF4A, LASP1, mTNBC, NACT, pCR, TNBC, Triple negative breast cancer
Category(s): Oncology