Search Results - frank+porreca

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Kappa Opioid Receptor Antagonists for Sleep Disorders
Researchers at UArizona have discovered that kappa opioid receptors influence sleep in mice struggling with chronic pain. In particular they found that a kappa opioid receptor antagonist could be beneficial for improvement of sleep related to pain conditions, as well as other conditions where increased kappa opioid receptor signaling has been observed....
Published: 4/3/2023   |   Inventor(s): Frank Porreca, Hisakatsu Ito, Edita Navratilova
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Sleep Disorders, Technology Classifications > Life Sciences > Therapeutics
Discovery of Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor
This invention is a dynorphin analog designed to interact with a receptor that is partly responsible for pain sensations. Dynorphin analog targets the bradykinin receptors instead of the f NMDA receptors. The ligands are novel in the deletion of an arginine residue in position 7 which has been recognized as an essential residue for opioid and non-opioid...
Published: 4/3/2023   |   Inventor(s): Yeon Sun Lee, Victor Hruby, Josephine Lai, Frank Porreca
Keywords(s): [des-Arg7]-dynorphin analogs, amphipathic bradykinin receptor, non-opioid effect of dynorphin, pain, pharmacophore
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules